Difference between revisions of "Team:SDU-Denmark/Tour10"

 
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<p> <i> "Change is the law of life and  those who look only to the past or present are certain to miss the future." - <b>John F. Kennedy</b></i> </p>
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<h1 align="center"> Project description </h1>  
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  <img src="https://static.igem.org/mediawiki/2014/a/a3/2014SDUforside10.png">
 
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<h2 class="onBlack">Antibody</h2>
 
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Click to visit Mamma’s Burgers!
 
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People tend to fear bacteria and oppose genetic modification, and thus synthetic biology. Our attempt at a novel outreach approach will teach the audience facts about bacteria, DNA and GMO in a fun and participatory way.<br><br>
 
  
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At the burger joint, Mamma's Burgers, crazy things might happen but it sure will be educational!
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<a class="popupImg alignRight" style="width:150px" target="_blank" href="https://static.igem.org/mediawiki/2015/6/6a/SDU2015_Babymice.png" title="Baby mice who will be brought up as laboratory animals and used for antibody production. The aim of this project is to find an alternative to the use of animals in the antibody production.">
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<div class="thumbcaption">Figure 1: Photo of baby mice taken at the animal facilities at Odense University Hospital (OUH). </div>
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<h2 class="onBlack">The Untapped Food Resource of the Century</h2>
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Edible coli is a proposal for a sustainable food source.
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A modified strain of the bacteria <i>Escherichia coli</i> will provide the optimal quantities of nutrition a human needs, by degrading otherwise non-degradable material for the human body. <br><br>
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First step is the production of a nutritional protein, the OneProt, and the biosynthesis of essential fatty acids – additionally, it will carry the appealing touch of lemon flavor. Then the Nutrition Generator, a custom designed, innovative and revolutionary cultivation tank will ensure an on-going amplification of the Edible coli products, easy to handle and drain from.<br><br>
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Could the world live off of microorganisms?
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<div class="thumbcaption">Figure 2: Members of the team discussing something in the laboratory. </div>
 
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<span class="intro">Monoclonal antibodies (mAbs) are extensively used in scientific and fundamental medical research</span>.   
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The nowadays production methods of mAbs are not only time-consuming and costly but also at the expense of animal lives. Antibodies have many applications in research, diagnostics and show great promise in treatment of cancer. But the advancement is held back due to the expensive and time consuming production. Therefore we propose an alternative to antibodies; peptide aptamers – produced in <i>Escherichia coli</i> (<i>E. coli</i>). The variable loop of the peptide aptamer is generated through a random nucleotide library and held together by an optimized, enzymatic inactive version of human Thioredoxin (hTrx) used as a scaffold protein. We are using the bacterial two-hybrid system to generate and, at the same time, screen for peptide aptamers with desired properties. Additionally we are proposing a production model. 
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<span class="intro">Our team consists</span> of nine students from five different educations; philosophy, chemical engineering, biochemistry and molecular biology, biomedicine and medicine. During the last 6 months we have laughed, cried, built friendships and overcome a lot of struggles together. In the end of the day it has been a whole lot of fun! To guide and help us through the journey, we have had our four supervisors. Go to the next page <a href="https://2015.igem.org/Team:SDU-Denmark/Tour11">the team</a> and dig deeper into the members of the SDU Denmark 2015 iGEM team.
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Latest revision as of 03:28, 19 September 2015

iGEM logo
Introduction
Antibody issue
PAST
Process
Results
Practices
What is Next

"Change is the law of life and those who look only to the past or present are certain to miss the future." - John F. Kennedy

Project description

Figure 1: Photo of baby mice taken at the animal facilities at Odense University Hospital (OUH).
Figure 2: Members of the team discussing something in the laboratory.

Monoclonal antibodies (mAbs) are extensively used in scientific and fundamental medical research. The nowadays production methods of mAbs are not only time-consuming and costly but also at the expense of animal lives. Antibodies have many applications in research, diagnostics and show great promise in treatment of cancer. But the advancement is held back due to the expensive and time consuming production. Therefore we propose an alternative to antibodies; peptide aptamers – produced in Escherichia coli (E. coli). The variable loop of the peptide aptamer is generated through a random nucleotide library and held together by an optimized, enzymatic inactive version of human Thioredoxin (hTrx) used as a scaffold protein. We are using the bacterial two-hybrid system to generate and, at the same time, screen for peptide aptamers with desired properties. Additionally we are proposing a production model.

Our team consists of nine students from five different educations; philosophy, chemical engineering, biochemistry and molecular biology, biomedicine and medicine. During the last 6 months we have laughed, cried, built friendships and overcome a lot of struggles together. In the end of the day it has been a whole lot of fun! To guide and help us through the journey, we have had our four supervisors. Go to the next page the team and dig deeper into the members of the SDU Denmark 2015 iGEM team.







Next chapter

Next chapter

Dig deeper

End of tour

Want more? Go to iGEM.org!

If you want to learn more about Synthetic Biology you should visit iGEM's homepage, which contains loads on the subject. You can even visit other teams' wikis and take a look at what they accomplished. Or maybe join a team yourself?