Difference between revisions of "Team:NJU-China/Modeling"

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<h2> Modeling</h2>
 
  
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<p>In order to be considered for the <a href="https://2015.igem.org/Judging/Awards#SpecialPrizes">Best Model award</a>, you must fill out this page.</p>
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<li><a href="NJU-China-aknow.html" style="font-weight:bold;font-family:Microsoft YaHei">acknowledgement</a></li>
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<p>Mathematical models and computer simulations provide a great way to describe the function and operation of BioBrick Parts and Devices. Synthetic Biology is an engineering discipline, and part of engineering is simulation and modeling to determine the behavior of your design before you build it. Designing and simulating can be iterated many times in a computer before moving to the lab. This award is for teams who build a model of their system and use it to inform system design or simulate expected behavior in conjunction with experiments in the wetlab.</p>
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Here are a few examples from previous teams:
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Home</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-background.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Background</a></li>
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<div style="line-height:250%;margin-left:10%" id="main1" onClick="document.all.child0.style.display=(document.all.child0.style.display =='none')?'':'none'" ><a href="#" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Project</a></div>
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<ul>
 
<ul>
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<li><a href="https://2014.igem.org/Team:ETH_Zurich/modeling/overview">ETH Zurich 2014</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/Design" style="font-weight:bold;font-family:幼圆;color:black">design</a></li>
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<li><a href="https://2014.igem.org/Team:Waterloo/Math_Book">Waterloo 2014</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-project/result.html" style="font-weight:bold;font-family:幼圆;color:black">results</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-project/conclusion.html" style="font-weight:bold;font-family:幼圆;color:black">conclusion</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-project/future work.html" style="font-weight:bold;font-family:幼圆;color:black">future work</a></li>
 
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<div style="line-height:250%;margin-left:10%" id="main1" onClick="document.all.child1.style.display=(document.all.child1.style.display =='none')?'':'none'" ><a href="#" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Model</a></div>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-model.html" style="font-weight:bold;font-family:幼圆;color:black">Delivery Module</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/RNAi" style="font-weight:bold;font-family:幼圆;color:black">RNAi Module</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/signaling" style="font-weight:bold;font-family:幼圆;color:black">Signaling Module</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/Practices" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Human Practice</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-parts.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Parts</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-team.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Team</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-attribution.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Attribution</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/Collaborations" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Colaborations</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-safty.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Safety</a></li>
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<div style="line-height:250%;margin-left:10%" id="main2" onClick="document.all.child2.style.display=(document.all.child2.style.display =='none')?'':'none'" > <a href="#" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Notebook </div>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-notebook.html#methods" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Methods</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-notebook.html#protocal" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Protocal</a></li>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-notebook.html#notebook" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Notebook</a></li>
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</ul>
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</div>
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<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-acknowledgement.html#notebook" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Acknowledgement</a></li>
  
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<h1> Modeling overview </h1>
  
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We created mathematical models of three aspects of our project: a
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pharmacokinetic model, RNA inference model and signaling network model.
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The source code of the modeling work is available <a href="https://static.igem.org/mediawiki/2015/4/4a/Model_Code.zip">here</a> or on our <a href="https://github.com/eldronzhou/IGEM-NJU-China-2015">Github Page</a> to help others
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reproduce and improve our work. <br><br>
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The delivery module used experimental results to simulate the kinetics
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of tissue-distribution of exosomes. The RNAi module modeled the
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kinetics of downregualtion of MOR protein in response to anti-MOR
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siRNA. The signaling module theoretically predicted the impacts of
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downregulating MOR protein on the reward pathway and explained the
 +
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behavioral change of mice observed in our laratory work. We had a
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better understanding of our device by integrating three modules.
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<br><br>
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Latest revision as of 03:36, 3 October 2015

humanpractice


  • Home
  • Background
  • Human Practice
  • Parts
  • Team
  • Attribution
  • Colaborations
  • Safety
  • Acknowledgement
    		•

    Modeling overview

    We created mathematical models of three aspects of our project: a pharmacokinetic model, RNA inference model and signaling network model. The source code of the modeling work is available here or on our Github Page to help others reproduce and improve our work.

    The delivery module used experimental results to simulate the kinetics of tissue-distribution of exosomes. The RNAi module modeled the kinetics of downregualtion of MOR protein in response to anti-MOR siRNA. The signaling module theoretically predicted the impacts of downregulating MOR protein on the reward pathway and explained the behavioral change of mice observed in our laratory work. We had a better understanding of our device by integrating three modules.