Welcome to Tour Section
As there is a resistance developing against H. Pylori, we aimed to eradicate it with synthetic biology. Meet Wile E. Coli! He had some modifications to cure ulcer, the ulcer made by Helico Runner(beep-beep!)
Here are our project’s parts in a little fast tour!
Are you ready to learn the journey of Wile E. Coli and Helico Runner? Then change the frames with mouse or up and down keys!
1 Resistance
![](https://static.igem.org/mediawiki/2015/0/06/ATOMS-Turkiye_tour1.jpg)
At first, it will be acid resistant, to survive in stomach’s acidic microenvironment!
2 Repellency
![](https://static.igem.org/mediawiki/2015/c/c5/ATOMS-Turkiye_tour2.jpg)
Secondly, as Wile E. coli needed to find its way properly, he now has a part for targeting Helico
Runner; chemotaxis part!
3 Motility
![](https://static.igem.org/mediawiki/2015/c/cf/ATOMS-Turkiye_tour3.jpg)
Thirdly, we had to make sure Wile E. Coli reached to Helico Runner, so now it can penetrate into the
mucos layer with its faster flagellas!
4 Sensing
![](https://static.igem.org/mediawiki/2015/a/ad/ATOMS-Turkiye_tour4.jpg)
The fourth part And gate, is designed to make Wile E. Coli sensing Helico Runner. Look! It’s not
chasing the fake Helico Runner anymore!
5 Killing
![](https://static.igem.org/mediawiki/2015/6/61/ATOMS-Turkiye_tour5.jpg)
Thanks to our fifth part, Wile E. Coli can destroy Helico Runner with the antimicrobial peptide
Pexiganan. Revenge time!
Cancer
![](https://static.igem.org/mediawiki/2015/0/00/ATOMS-Turkiye_tour6.jpg)
Oh wait, what if gastric ulcer causes gastric cancer? How will we open this cancer door to reach and
cure it?
miRNA Switch
![](https://static.igem.org/mediawiki/2015/f/fb/ATOMS-Turkiye_tour7.jpg)
Here is the solution; miRNA switch! Mr. exosome has a key to open the door now. Just like key
matches the lock, if miRNAs match the switch we can target cancer more specifically now!
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