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| | <li> | | <li> |
| | <span>Why do we detect mercury?</span> | | <span>Why do we detect mercury?</span> |
| − | <p class="article-p">通常食用油中是不會含有如此超標的重金屬汞。食用油裡會含有超標的汞原因是動物攝入甲基汞後囤積於內臟（註1），而餿水油是由內臟油加工製成，但汞不容易被人體代謝掉進而累積在體內造成嚴重的疾病，所以我們才會偵測汞這個重金屬。</p> | + | <p class="article-p">Normally, there wont be such amount of heavy metal be contained in edible oil. Edible oil excessive mercury is because methyl mercury will be hoard in animal internal organs after eating by them. And recycled oil was made from animal internal organs . After we eat recycled oil into our body, it wont be metabolized easily and lead to serious disease. Due to the reasons above, we decided to detect this heavy metal.[1]</p> |
| | </li> | | </li> |
| | <li> | | <li> |
| | <span>The harm of mercury</span> | | <span>The harm of mercury</span> |
| − | <p class="article-p">甲基汞是已知的神經毒物，會抑制神經細胞的分裂及電離子的移動並干擾發育中的腦部結構，除此之外，甲基汞還能引起心血管疾病包括心肌梗塞與缺血性心臟病、高血壓及心律不整（註2）。</p> | + | <p class="article-p">It's common knowledge that Methyl mercury is neurotoxin . It represses cell division and restricts motility of electronic ions. It can also interfere with growing brain structure. Besides, methyl mercury can also result in cardiovascular disease like myocardial infarction, Ischemic Heart Disease，hypertension and irregular pulse.[2]</p> |
| | </li> | | </li> |
| | <li> | | <li> |
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| | <h3 class="article-title">Circuit Design</h3> | | <h3 class="article-title">Circuit Design</h3> |
| | <div class="article-img"><img src="https://static.igem.org/mediawiki/2015/7/7e/2015hsnu-mercury1.png"></div> | | <div class="article-img"><img src="https://static.igem.org/mediawiki/2015/7/7e/2015hsnu-mercury1.png"></div> |
| − | <p class="article-p">MerR可以和汞結合然後改變DNA的結構好讓RNA聚合酶方便轉入。PmerT可以被MerR控制。PmerT步行進行轉錄是因為MerR會改變PmerT的形狀。總而言之，只要汞與MerR結合，後續反應就可進行。(註3)(註4)</p> | + | <p class="article-p">MerB can turn Methyl mercury into Hg2+.MerR can combine with Hg2+ and change the structure of DNA. And DNA can be trancripted easier. PmerT is controlled by MerR. PmerT cannot be transcripted because MerR changes the shape of PmerT. In short, the whole reaction will continue if MerR combines with Hg2+.[3][4]</p> |
| | <div class="article-img"><img src="https://static.igem.org/mediawiki/2015/b/b2/2015hsnu-mercury_2.png"></div> | | <div class="article-img"><img src="https://static.igem.org/mediawiki/2015/b/b2/2015hsnu-mercury_2.png"></div> |
| | </article> | | </article> |
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| | <h3 class="article-title">Reference</h3> | | <h3 class="article-title">Reference</h3> |
| | <ul class="article-ul"> | | <ul class="article-ul"> |
| − | <li>(註1)Metabolism of mercury, administered as methylmercuric chloride or mercuric chloride, by lactating ruminants.</li> | + | <li>[1]J. Agric. Food Chem., 1975, “Metabolism of mercury, administered as methylmercuric chloride or mercuric chloride, by lactating ruminants”.23 (4), pp 803–808,DOI: 10.1021/jf60200a013 |
| − | <li>(註2)台北醫學大學公共衛生學系碩士班碩士論文Graduate Institute.</li> | + | Publication Date: July 1975 |
| − | <li>(註3)Brown, N. L., J. V. Stoyanov, et al. (2003). "The MerR family of transcriptional regulators." FEMS Microbiol Rev 27(2-3): 145-163.</li> | + | </li> |
| − | <li>(註4)Park, S. J., J. Wireman, et al. (1992). "Genetic analysis of the Tn21 mer operator-promoter." J Bacteriol 174(7): 2160-2171.</li> | + | <li>[2]Knowledge、Attitude、Practice and risk assessment of mercury exposure through the consumption of fish from the mercury containminated area邱宇昕,JULY/2007</li> |
| | + | <li>[3]Brown, N. L., J. V. Stoyanov, et al. (2003). "The MerR family of transcriptional regulators." FEMS Microbiol Rev 27(2-3): 145-163.</li> |
| | + | <li>[4]Park, S. J., J. Wireman, et al. (1992). "Genetic analysis of the Tn21 mer operator-promoter." J Bacteriol 174(7): 2160-2171.</li> |
| | </ul> | | </ul> |
| | </article> | | </article> |
