Difference between revisions of "Team:Korea U Seoul/Team/Attributions/content"

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                  Background
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                  Attributions
 
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    Sortases, enzymes that recognize and cleave the specific sorting signal of secreted proteins to form isopeptide bonds between the secreted proteins and polypeptides, function as protein ligase to form the cell-wall surface of gram-positive bacteria. In case of <i>C.diphtheriae</i>, which belongs to the same genus of our experimental bacteria <i>Corynebacterium glutamicum</i>, has total of 6 sortases, 5 pilus specific sortases (Srt A,B,C,D,E) and 1 housekeeping sortase (Srt F) involved in the formation of all types of pili. <br />
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    <h1>Software Backend</h1>
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There are 9 types of pillins that comprise pilus; Spa A, B, C, D, E, F, G, H, I, J. SrtA build up SpaA-type pili, which is composed of Spa A, B and C. Srt B/C and Srt d/E each forms SpaD-type pili and SpaH-type pili, which is made up of Spa D, E, F and Spa H, I, J respectively. Like this, the names of each pili types are generally from the names of many Spa proteins. <br />
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        <h3>Data Collection: Deok ho Kim, Sumin Cho, Seong-ju Lee, Jiwon Kim</h3>
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The picture below shows the process of SpaA type pili formation, using SrtA. Sortase class A enzymes recognize the sequence LPXTG at the carboxyl terminus of surface protein precursors. Cystein of SrtA recognizes LPXTG motif of SpaC, cleaves between T and G, forming SpaC-SrtA intermediate via nucleophilic attack. This intermediate is again attacked by lysine of SrtA bounded SpaA, and the process is continued to form SpaC–SpaAn–SrtA intermediates.<br />
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<h3>Pathway Scoring: Jeongsu Hwang, SooWhan Kim, Sumin Cho, Seong-ju Lee, Jiwon Kim</h3>
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Nucleophilic attack by Lysine of SrtF bounded SpaB form SpaC-SpaA(n)-SpaB-SrtF intermediate. The product of this SrtA reaction is covalently linked to lipidⅡ and is then incorporated into the cell wall envelope, terminating the formation of SpaA-type pilus.
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<h3>Database Contruction: Sumin Cho, Seong-ju Lee, Jiwon Kim</h3>
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<h1>Software Frontend</h1>
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<h3>Web Design: Hyeong Woo Kim</h3>
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<h3>Web Publishing: Kyeong-hun Jeong, Min ki Choi, Deok ho Kim</h3>
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<h1>Wet-lab Work</h1>
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<h3>Kyujin Jeong, HyeYeong, JuYoung Han, Junhee Kim, Eun San Ko</h3>
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<h1>Wiki</h1>
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<h3>All team members
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</h3>
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<h1>Funding</h1>
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<h3>All team members<h3>
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<h1>Presentation<h1>
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<h3>Deok ho Kim, SooWhan Kim, Kyujin Jeong, Jiseung Lee
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<h3>
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<h1>Design<h1>
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<h3>Hyeong Woo Kim<h3>
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Human Practices
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All team members
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Instructor
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Byeong-nam Min, Kyoungwoo Jang, and Prof. In Geol Choi
 
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Revision as of 18:25, 16 September 2015

Attributions

Software Backend

Data Collection: Deok ho Kim, Sumin Cho, Seong-ju Lee, Jiwon Kim

Pathway Scoring: Jeongsu Hwang, SooWhan Kim, Sumin Cho, Seong-ju Lee, Jiwon Kim

Database Contruction: Sumin Cho, Seong-ju Lee, Jiwon Kim

Software Frontend

Web Design: Hyeong Woo Kim

Web Publishing: Kyeong-hun Jeong, Min ki Choi, Deok ho Kim

Wet-lab Work

Kyujin Jeong, HyeYeong, JuYoung Han, Junhee Kim, Eun San Ko

Wiki

All team members

Funding

All team members

Presentation

Deok ho Kim, SooWhan Kim, Kyujin Jeong, Jiseung Lee

Design

Hyeong Woo Kim

Human Practices All team members Instructor Byeong-nam Min, Kyoungwoo Jang, and Prof. In Geol Choi