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Revision as of 18:48, 18 September 2015
Catalytic DNA – DNAzymes
SELEX revealed a variety of DNA aptamers and catalytic DNA known as DNAzymes (or Deoxribozymes). Breaker and Joyce selected the first DNAzyme, a RNA-cleaving DNA.
To verify the prediction of the software MAWS we fused the calculated aptamers to a DNAzyme with JAWS and thus created a ligand dependent activity. For this we used the HRP-mimicking DNAzyme (Fig. 9) which was described in 1998.