Difference between revisions of "Template:Heidelberg/pages/achievments"

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       <li><p class="basictext">We developed a NEW STANDARD to easily clone functional RNAs for their expression in vitro and in vivo (RFC 101)
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      <li>Liebe geht über Triebe</li>
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      <li>Tante fällt über Kante</li>
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<li><p class="basictext">We established a NOVEL dual-color readout system to monitor the in vitro transcription of an RNA of interest based on a new ATP-switchable Spinach II ribozyme
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<li><p class="basictext">We established a NOVEL detection method for short ssDNAs and ssRNAs based on the HRP-mimicking DNAzyme
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<li><p class="basictext">We designed de novo an ACTIVE SITE for twin ribozyme and proved its efficient cleavage activity in living yeast cells
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<li><p class="basictext">We conceived and implemented an open-source software for the design of aptamers (MAWS) as a fast and affordable alternative to the laborious SELEX procedure
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<li><p class="basictext">We conceived and implemented an open-source software for the design of aptazymes (JAWS) to enable the construction of new sensing devices
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<li><p class="basictext">We EXPERIMENTALLY VALIDATED several of our designed aptamers and aptazymes and fed the collected data back into the algorithms
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Revision as of 01:16, 19 September 2015

TITLE

We established a NEW APPROACH to work with all types of functional nucleic acids, setting the foundations for their widespread use in synthetic biology

  • We developed a NEW STANDARD to easily clone functional RNAs for their expression in vitro and in vivo (RFC 101)

  • We established a NOVEL dual-color readout system to monitor the in vitro transcription of an RNA of interest based on a new ATP-switchable Spinach II ribozyme

  • We established a NOVEL detection method for short ssDNAs and ssRNAs based on the HRP-mimicking DNAzyme

  • We designed de novo an ACTIVE SITE for twin ribozyme and proved its efficient cleavage activity in living yeast cells

  • We conceived and implemented an open-source software for the design of aptamers (MAWS) as a fast and affordable alternative to the laborious SELEX procedure

  • We conceived and implemented an open-source software for the design of aptazymes (JAWS) to enable the construction of new sensing devices

  • We EXPERIMENTALLY VALIDATED several of our designed aptamers and aptazymes and fed the collected data back into the algorithms




We proved the PRINCIPLE that a ketamine-switchable aptazyme could be used to implement a TEST STRIPE to detect RAPE DRUGS in situ




We established a NEW APPROACH to work with all types of functional nucleic acids, setting the foundations for their widespread use in synthetic biology