Difference between revisions of "Template:Heidelberg/pages/achievments"

Line 8: Line 8:
 
<div class="panel panel‐default">
 
<div class="panel panel‐default">
 
<div class="panel‐heading">
 
<div class="panel‐heading">
−
<h3 class="basicheader"> TITLE </h3>
 
 
</div> <!-- panel-heading -->
 
</div> <!-- panel-heading -->
 
<div class="panel‐body">
 
<div class="panel‐body">

Revision as of 01:21, 19 September 2015

We established a NEW APPROACH to work with all types of functional nucleic acids, setting the foundations for their widespread use in synthetic biology

  • We developed a NEW STANDARD to easily clone functional RNAs for their expression in vitro and in vivo (RFC 110)

  • We established a NOVEL dual-color readout system to monitor the in vitro transcription of an RNA of interest based on a new ATP-switchable Spinach II aptamer

  • We established a NOVEL detection method for short ssDNAs and ssRNAs based on the HRP-mimicking DNAzyme

  • We designed de novo an ACTIVE SITE for twin ribozyme and proved its efficient cleavage activity in living yeast cells

  • We conceived and implemented an open-source software for the design of aptamers (MAWS) as a fast and affordable alternative to the laborious SELEX procedure

  • We conceived and implemented an open-source software for the design of aptazymes (JAWS) to enable the construction of new sensing devices

  • We EXPERIMENTALLY VALIDATED several of our designed aptamers and aptazymes and fed the collected data back into the algorithms




We proved the PRINCIPLE that a ketamine-switchable aptazyme could be used to implement a TEST STRIPE to detect RAPE DRUGS in situ




We established a NEW APPROACH to work with all types of functional nucleic acids, setting the foundations for their widespread use in synthetic biology