We comply with general safety including appropriate clothing in lab, lab environment, usage of safety equipments, emergency procedures of lab, the regulation of public lab equipments and biological lab waste management and so on. Besides, before and after experiment, we will spray 70% alcohol to make sure bench remain clean. And when we culture cell line in culture room, we will also turn on the UV light to avoid any possible contamination. And for further safety, we are not testing our system with OSCC cells in our validation experiment. We are going to test our prototype by synthetic nucleic acid from IDT and secreted protein from LPS-treat THP1 cell line to mimic the microenvironment of saliva in OSCC patients. Because THP1 cell line is a pathogen-free cell line, it is safer for our prototype validation than using OSCC cell line directly.