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HRP-mimicking DNAzyme

HRP-mimicking DNAzyme folds into a G-quadruplex and binds hemin into it. Upon binding of the hemin to the G-quadruplex the DNAzyme catalyzes the reduction of H₂O₂ to H₂O and a reactive oxygen species and thus result to the activation of a classical HRP substrate like luminol.

HRP-micking DNAzyme

HRP-mimicking DNAzyme folds into a G-quadruplex and binds hemin into it. Upon binding of the hemin to the G-quadruplex the DNAzyme catalyzes the reduction of H₂O₂ to H₂O and a reactive oxygen species and thus result to the activation of a classical HRP substrate like luminol.