Difference between revisions of "Team:DTU-Denmark"
| Line 37: | Line 37: | ||
<i class="fa fa-bars"></i> | <i class="fa fa-bars"></i> | ||
</button> | </button> | ||
| − | <a class="navbar-brand navimg" href="#"><img src="https:// | + | <a class="navbar-brand navimg" href="#"><img src="https://static.igem.org/mediawiki/2015/b/b7/DTU-Denmark_dtulogo.png"></a> |
</div> | </div> | ||
<!-- Collect the nav links, forms, and other content for toggling --> | <!-- Collect the nav links, forms, and other content for toggling --> | ||
| Line 192: | Line 192: | ||
<li class="hidden-lg"> | <li class="hidden-lg"> | ||
<a href="https://igem.org" target="_blank" class="navimg"> | <a href="https://igem.org" target="_blank" class="navimg"> | ||
| − | <img src="https:// | + | <img src="https://static.igem.org/mediawiki/2015/a/af/DTU-Denmark_igemlogo.png"> |
</a> | </a> | ||
</li> | </li> | ||
| Line 210: | Line 210: | ||
| − | <div class="jumbotron hero" style="background-image: url(https:// | + | <div class="jumbotron hero" style="background-image: url(https://static.igem.org/mediawiki/2015/0/0b/DTU-Denmark_hero.jpg)"> |
<div class="igem-logo visible-lg"> | <div class="igem-logo visible-lg"> | ||
<a href="https://igem.org" target="_blank"> | <a href="https://igem.org" target="_blank"> | ||
| − | <img src="https:// | + | <img src="https://static.igem.org/mediawiki/2015/a/af/DTU-Denmark_igemlogo.png"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 279: | Line 279: | ||
<p style="text-align: center;">Visit the Synthesizers' stand during Giant Jamboree! Get tuned in and listen to our podcast explaining our project!</p> | <p style="text-align: center;">Visit the Synthesizers' stand during Giant Jamboree! Get tuned in and listen to our podcast explaining our project!</p> | ||
| − | <p style="text-align: center;"><img alt="" src="/ | + | <p style="text-align: center;"><img alt="" src="https://static.igem.org/mediawiki/2015/7/7d/DTU-Denmark_drawingpng.png" style="width: 625px; height: 378px;" /></p> |
<p style="text-align: center;">Figure 1</p> | <p style="text-align: center;">Figure 1</p> | ||
| Line 321: | Line 321: | ||
| − | + | <footer class="container"> | |
<div class="row"> | <div class="row"> | ||
<div class="col-md-2 col-md-offset-2"> | <div class="col-md-2 col-md-offset-2"> | ||
<a href="http://www.dtu.dk" target="_blank"> | <a href="http://www.dtu.dk" target="_blank"> | ||
| − | <img src="https:// | + | <img src="https://static.igem.org/mediawiki/2015/b/b7/DTU-Denmark_dtulogo.png" height="130px"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 341: | Line 341: | ||
<div class="col-md-2"> | <div class="col-md-2"> | ||
<a href="https://igem.org" style="float:left" target="_blank"> | <a href="https://igem.org" style="float:left" target="_blank"> | ||
| − | <img src="https:// | + | <img src="https://static.igem.org/mediawiki/2015/a/af/DTU-Denmark_igemlogo.png" height="90px"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 352: | Line 352: | ||
<div class="sponsorlogo"> | <div class="sponsorlogo"> | ||
<a href="http://www.lundbeckfonden.com/" target="_blank"> | <a href="http://www.lundbeckfonden.com/" target="_blank"> | ||
| − | <img src="/ | + | <img src="https://static.igem.org/mediawiki/2015/e/e2/DTU-Denmark_Lundbeckfonden.jpg"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 358: | Line 358: | ||
<div class="sponsorlogo"> | <div class="sponsorlogo"> | ||
<a href="http://www.ottomoensted.dk" target="_blank"> | <a href="http://www.ottomoensted.dk" target="_blank"> | ||
| − | <img src="/ | + | <img src="https://static.igem.org/mediawiki/2015/3/35/DTU-Denmark_Ottomoensted.png"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 364: | Line 364: | ||
<div class="sponsorlogo"> | <div class="sponsorlogo"> | ||
<a href="http://www.novonordiskfonden.dk/en" target="_blank"> | <a href="http://www.novonordiskfonden.dk/en" target="_blank"> | ||
| − | <img src="/ | + | <img src="https://static.igem.org/mediawiki/2015/5/5c/DTU-Denmark_NovoNordiskFonden_logo.png"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 370: | Line 370: | ||
<div class="sponsorlogo"> | <div class="sponsorlogo"> | ||
<a href="https://dk.vwr.com/" target="_blank"> | <a href="https://dk.vwr.com/" target="_blank"> | ||
| − | <img src="/ | + | <img src="https://static.igem.org/mediawiki/2015/e/ea/DTU-Denmark_VWR.jpg"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 376: | Line 376: | ||
<div class="sponsorlogo"> | <div class="sponsorlogo"> | ||
<a href="http://frisenette.dk" target="_blank"> | <a href="http://frisenette.dk" target="_blank"> | ||
| − | <img src="/ | + | <img src="https://static.igem.org/mediawiki/2015/c/c8/DTU-Denmark_Frisenette.jpg"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 394: | Line 394: | ||
<div class="sponsorlogo"> | <div class="sponsorlogo"> | ||
<a href="http://us.akg.com/akg-homepage-us.html" target="_blank"> | <a href="http://us.akg.com/akg-homepage-us.html" target="_blank"> | ||
| − | <img src="/ | + | <img src="https://static.igem.org/mediawiki/2015/9/9d/DTU-Denmark_AKG.png"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 400: | Line 400: | ||
<div class="sponsorlogo"> | <div class="sponsorlogo"> | ||
<a href="http://www.macrogen.com/" target="_blank"> | <a href="http://www.macrogen.com/" target="_blank"> | ||
| − | <img src="/ | + | <img src="https://static.igem.org/mediawiki/2015/1/11/DTU-Denmark_Marcogen.jpg"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 406: | Line 406: | ||
<div class="sponsorlogo"> | <div class="sponsorlogo"> | ||
<a href="http://www.snapgene.com/" target="_blank"> | <a href="http://www.snapgene.com/" target="_blank"> | ||
| − | <img src="/ | + | <img src="https://static.igem.org/mediawiki/2015/5/58/DTU-Denmark_Snapgene.png"> |
</a> | </a> | ||
</div> | </div> | ||
| Line 412: | Line 412: | ||
<div class="sponsorlogo"> | <div class="sponsorlogo"> | ||
<a href="https://www.neb.com/" target="_blank"> | <a href="https://www.neb.com/" target="_blank"> | ||
| − | <img src="/ | + | <img src="https://static.igem.org/mediawiki/2015/e/e0/DTU-Denmark_NEB_logo.png"> |
</a> | </a> | ||
</div> | </div> | ||
Revision as of 14:12, 9 November 2015
Project Description
Visit the Synthesizers' stand during Giant Jamboree! Get tuned in and listen to our podcast explaining our project!
Figure 1
Non-ribosomal peptides have important anti-bacterial, anti-cancer, and immunosuppressive biological activities. They are synthesized by modular, high molecular weight enzymes that assemble more than 500 different amino acid substrates in an assembly line manner. For this reason, synthetic biologists have tried to engineer these proteins and to switch modules to create analogs and novel natural products, but with little success. Despite being modular, the interactions between modules have evolved to be highly specific, making synthetic Non-Ribosomal Peptide Synthases (NRPS) a challenge to engineer. Instead of switching modules we introduced a recombination system targeting oligo integration in Bacillus subtilis. We used the recombineering system to alter the active sites determining substrate specificity, thereby creating variants of antibiotics. Our focus was the tyrocidine antibiotic, which cannot be used intravenously due to its toxicity. Our goal is to create new analogs through multiplex automated genome engineering to reduce toxicity.
