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style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial" y="61.803959" x="599.44971" id="tspan4684">1. Apoptosis is induced only in cancer cells</tspan><tspan id="tspan4710" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial" y="80.553955" x="599.44971">by sTRAIL and causes phosphotadylserine (PS)</tspan><tspan id="tspan4712" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial" y="99.303955" x="599.44971">to flip to the outer membrane.</tspan></text> <text xml:space="preserve" style="font-style:normal;font-weight:normal;font-size:40px;line-height:125%;font-family:Sans;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" x="543.49072" y="259.81256" id="text4714"><tspan x="543.49072" y="259.81256" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial" id="tspan4720">2. Mammalian cells and MicroBeacons are sent</tspan><tspan id="tspan4727" x="543.49072" y="278.56256" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial">through the microfluidic chip.</tspan></text> <text xml:space="preserve" style="font-style:normal;font-weight:normal;font-size:40px;line-height:125%;font-family:Sans;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" x="728.28436" y="376.95023" id="text4714-8"><tspan id="tspan4752" x="728.28436" y="376.95023" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial">3. MicroBeacons with membrane-</tspan><tspan id="tspan4756" x="728.28436" y="395.70023" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial">expressed annexin V bind to exposed</tspan><tspan id="tspan4758" x="728.28436" y="414.45023" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial">PS on apoptotic cancer cells and not to</tspan><tspan id="tspan4760" x="728.28436" y="433.20023" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial">normal cells.</tspan></text> <text id="text4824" y="584.94092" x="-0.19042969" style="font-style:normal;font-weight:normal;font-size:40px;line-height:125%;font-family:Sans;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" xml:space="preserve"><tspan id="tspan4843" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial" y="584.94092" x="-0.19042969">4. Higher lactate production rates in the</tspan><tspan id="tspan4849" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial" y="603.69092" x="-0.19042969">apoptotic cancer cell initiates quorum </tspan><tspan id="tspan4861" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial" y="622.44092" x="-0.19042969">sensing between the MicroBeacons to </tspan><tspan id="tspan9742" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial" y="641.19092" x="-0.19042969">amplify the signal.</tspan></text> <text xml:space="preserve" style="font-style:normal;font-weight:normal;font-size:40px;line-height:125%;font-family:Sans;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" x="723.08173" y="594.36316" id="text4863"><tspan x="723.08173" y="594.36316" style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:15px;font-family:Arial;-inkscape-font-specification:Arial" id="tspan4869">5. 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