Team:NJU-China/Modeling

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Home Background Project design results conclusion future work Model Delivery Module RNAi Module Signaling Module Human Practice Parts Team Attribution Colaborations Safety Notebook Methods Protocal Notebook Acknowledgement

Modeling overview We created mathematical models of three aspects of our project: a pharmacokinetic model, RNA inference model and signaling network model. The source code of the modeling work is available here to help others reproduce and improve our work. The delivery module used experimental results to simulate the kinetics of tissue-distribution of exosomes. The RNAi module modeled the kinetics of downregualtion of MOR protein in response to anti-MOR siRNA. The signaling module theoretically predicted the impacts of downregulating MOR protein on the reward pathway and explained the behavioral change of mice observed in our laratory work. We had a better understanding of our device by integrating three modules.