Team:TCU Taiwan/Project/Overview
AMP. coli |
AMPs have an extensive ability in disinfect. Unlike antibiotics, AMPs use chargeability puncture the cell membrane to kill the bacteria therefore by passing bacterial antibiotic drug resistance mechanisms.[1] Two kinds of AMPs were selected as our reagents: Epinecidin-1 and Signiferin.
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• Epinecidin-1: 1. From the skin mucus of Epinephelus coioides a kind of fish. 2. Has function of killing bacteria. 3. In addition, it has the ability to help wounds healing and has been proven by animal studies. • Signiferin: 1. From the skin mucus of Crinia signifera a kind of tree frog. 2. Have function of killing bacteria. 3. Have great ability in disinfect Methicillin-Resistant Staphylococcus aureus (MRSA). 4. Had already been kindly proved by the 2013 TU-Delft iGEM team. 1. Helps AMPs to secret out of E. coli. 2. From Streptomyces lividans to trasport chitinase C to secretion system, which has been proven to work in E.coli by reference. Based on AMPs to develop into a potential material of wound dressing. |
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