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| − | <h1>Description</h1>
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| − | <h3>Overview</h3>
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| − | <p>Designed especially for the functioning cellular life form under the most favorable conditions, MCCAP (Minimal Cell Construct and Analyse Panel) is a software <b class="bianse">targeting to screen the minimal gene set</b>, based on a formal methodology (“top-down”) and a new method which means: if the number of organisms with this sort of essential gene have reached 50 percent or more, it will be reserved. Then you can utilize the minimal gene set, which consists of the essential gene that the software has filtered, to <b class="bianse">structure the metabolism network for modularization analysis</b>. What is more charming is its functions in different fields, varying from biological research to pharmaceutical application. MCCAP will inspire your interest by <b class="bianse">seeking our common ancestor, making the chassis of artificial cell, producing antimicrobial drug targets and promoting the synthesis of bacterial strain</b> which is more adapted to the needs as well.</p>
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| − | <h3>Project Motivation</h3>
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| − | <p><b class="bianse">Essential genes</b> are indispensable for the survival of living entitles, and the functions of proteins encoded by these genes are considered to be the foundation of life, <b class="bianse">they are the cornerstones of synthetic biology</b>. The study and exploration of essential genes, serving as the foundation of synthetic biology, plays an important role in this field. However, the development has been hampered. There are <b class="bianse">two obstacles</b>. Firstly, it is <b class="bianse">hard to measure the common essential genes</b>. Secondly, <b class="bianse">the interaction information between gene network and essential genes is far from enough</b>. MCCAP, Minimal Cell Construct and Analyse Panel, developed by us, is dedicated to these two problems. The software that we formulated obtains the ‘accessory’ essential gene from the species which are selected through experiments, and also MCCAP finds out the ‘core’ essential gene from it and gives the gene metabolic network analysis diagram. </p>
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| − | <h3>Background</h3>
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| − | <p>The numbers of genes in well-characterized genomes of cellular life forms range from as few as 480 parasitic bacterium Mycoplasma genitalium to~100,000-150,000 in multicellular eukaryotes, such as humans (Information on the completely sequenced genomes, including several complementary views of gene arrangement, can be found at
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| − | http://www.ncbi.nlm.nih.gov/Entrez/Genome/org.html)</p>
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| − | <h3>How Did We Do it ?</h3>
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| − | <p>MCCAP attains the vital data from CEG, processes the data and screens the essential gene set according to the inputs by users. </p>
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| − | <p>@2015 Designed & Developed by <span class="green_em">UESTC_SOFTWARE</span> iGEM</p>
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