Team:Valencia UPV/Modelling/DetModel

Valencia UPV iGEM 2015

Our deterministic model uses mathematical information contained in its equations, in order to provide results that depict the behavior of our device. Although how much is an important question, the value of this information overpasses the numerical frontiers, getting to the most important point when new and revolutionary devices are being tested, which is how. How does AladDNA behave is the main question that we want to answer with our modelling task. Take a sit and enjoy this wander in our mathematical chaos!


What is our device supposed to do? Circuit explanation

The idea of our circuit can be simply represented by this picture.

Basically, our aim is the biological design of a multiplexor that only expresses the genetic information when, where and which is desired by the user. The biological components that allow us this implementation in living organisms are two switches, two recombinases and a library of different binding domains. All those elements have been coordinated in this cascade of three different levels.


ComponentSymbol
DB1-PIF6
PhyB-VP16
BD2-LOV2
ePDZ-VP16
BxB1
ComponentSymbol
BD3-PIF6
BD4-LOV2
ƟC31
BD5-PIF6
BD6-LOV2

From Biochemical reactions to Mathematical equations


Mass Action Kinetics, Quasy Steady State Analysis

Hello world

Parameters values


Hello world