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        Every sequence of DNA hides a secret. Concealed throughout any genetic construct are mutation hotspots - DNA motifs prone to high rates of mutation. Once a mutation occurs at one of these sites, a mutant may rapidly overtake the population due to evolutionary selective pressure.
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      Our team has compiled decades of research into an algorithm that is able to eliminate these hotspots, reducing the risk of mutation for any gene without altering its function. We have also devised strategies for improving the evolutionary stability of entire genetic circuits, and have created new bacterial strains with their genomes engineered to better resist and repair mutations.
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Our foundational advance has the potential to revolutionize the way synthetic biologists optimize their genes, by looking beyond simple codon adaptation to consider the stability, safety, and reliability of DNA parts.</p>
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<p> <a href='https://2015.igem.org/Team:Vanderbilt/Project/Background'> <font color="#b92c45"> Join us as we expose the menaces lurking in your DNA. . . </font> </a>
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Latest revision as of 05:47, 21 November 2015

Vanderbilt iGEM 2015


Every sequence of DNA hides a secret. Concealed throughout any genetic construct are mutation hotspots - DNA motifs prone to high rates of mutation. Once a mutation occurs at one of these sites, a mutant may rapidly overtake the population due to evolutionary selective pressure.

Our team has compiled decades of research into an algorithm that is able to eliminate these hotspots, reducing the risk of mutation for any gene without altering its function. We have also devised strategies for improving the evolutionary stability of entire genetic circuits, and have created new bacterial strains with their genomes engineered to better resist and repair mutations.

Our foundational advance has the potential to revolutionize the way synthetic biologists optimize their genes, by looking beyond simple codon adaptation to consider the stability, safety, and reliability of DNA parts.

Join us as we expose the menaces lurking in your DNA. . .



Team

About
Members
Attributes
Sponsors

Project

Background
Sequence
Circuit
Organism
Nanopore
Achievements

Parts

Part Collection
Optimized RFPs
Visualizing Evolution
Repair Enzymes

Notebook

May
June
July
August
September

Practices

Safety
Collaborations
Applications
Interlab

Software

Development
User Guide
Statistics

Modeling

Sequences
Circuits
Populations