Difference between revisions of "Team:Vanderbilt"

 
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    <!-- Indicators -->
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        <img src="https://static.igem.org/mediawiki/2015/5/56/Vanderbilt_temp_carousel_pic.png" alt="Chania" width="460" height="345">
+
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+
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+
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+
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+
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+
        <span class="glyphicon glyphicon-chevron-left" aria-hidden="true"></span>
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+
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        <span class="glyphicon glyphicon-chevron-right" aria-hidden="true"></span>
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+
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 +
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    <div class="grid-item">
+
       <br>
       <img src="https://static.igem.org/mediawiki/2015/d/de/Vanderbilt_Text_box_background4.jpg" /></div>
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      <p>
    <div class="grid-item">
+
        Every sequence of DNA hides a secret. Concealed throughout any genetic construct are mutation hotspots - DNA motifs prone to high rates of mutation. Once a mutation occurs at one of these sites, a mutant may rapidly overtake the population due to evolutionary selective pressure.
       <img src="https://static.igem.org/mediawiki/2015/5/55/Vanderbilt_Sequence.jpg" /></div>
+
      </p>
    <div class="grid-item">
+
      <p>
      <img src="https://static.igem.org/mediawiki/2015/f/fd/Vanderbilt_Organism.jpg" /></div>
+
      Our team has compiled decades of research into an algorithm that is able to eliminate these hotspots, reducing the risk of mutation for any gene without altering its function. We have also devised strategies for improving the evolutionary stability of entire genetic circuits, and have created new bacterial strains with their genomes engineered to better resist and repair mutations.
    <div class="grid-item">
+
       </p>
      <img src="https://static.igem.org/mediawiki/2015/0/08/Vanderbilt_Circuit.jpg" /></div>
+
      <p>
     <div class="grid-item">
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Our foundational advance has the potential to revolutionize the way synthetic biologists optimize their genes, by looking beyond simple codon adaptation to consider the stability, safety, and reliability of DNA parts.</p>
      <div class="grid-item grid-item--widthFull grid-textbox-top">
+
<p> <a href='https://2015.igem.org/Team:Vanderbilt/Project/Background'> <font color="#b92c45"> Join us as we expose the menaces lurking in your DNA. . . </font> </a>
        <span class="span-text"> hullo this is paragraph 1 such an amazing paragraph how will spillag work i wonder</span>
+
      </p>
      </div>
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     </div> <!-- /col -->
      <div class="grid-item grid-item--widthFull grid-textbox-mid">
+
 
        <span class="span-text"> hullo this is paragraph 2 </span>
+
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      </div>
+
       <div class="row">
       <div class="grid-item grid-item--widthFull grid-textbox-bot">
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         <span class="span-text"> hullo this is paragraph 3 </span>
+
 
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       </div>
     </div>
+
      <div class="row">
   </div>
+
        <div class="col-sm-4">
 +
          <a href='https://2015.igem.org/wiki/index.php?title=Team:Vanderbilt/Project/Sequence'>
 +
          <img class="logo" src=" https://static.igem.org/mediawiki/2015/5/57/VU15_sequence_logo.png"    /> </a>
 +
        </div>
 +
        <div class="col-sm-4">
 +
          <a href='https://2015.igem.org/wiki/index.php?title=Team:Vanderbilt/Project/Circuit'>
 +
          <img class="logo" src="https://static.igem.org/mediawiki/2015/1/14/VU15_circuit_logo.png" /> </a>
 +
        </div>
 +
        <div class="col-sm-4">
 +
          <a href='https://2015.igem.org/wiki/index.php?title=Team:Vanderbilt/Project/Organism'>
 +
          <img class="logo" src="https://static.igem.org/mediawiki/2015/2/27/VU15_organism_logo.png" /></a>
 +
        </div>
 +
      </div>
 +
      <br>
 +
     </div> <!-- /col -->
 +
   </div> <!-- /row -->
  
<div class="row" style="margin:0; border: 0; width: 100%;">
+
</div> <!-- /col -->
  <div class="col-lg-2" style="height:100%">
+
    <h3><font color="#7e1d2e">Team</font></h3>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Team/About"><font color="#9e515e">About</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Team/Members"><font color="#9e515e">Members</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Team/Attributes"><font color="#9e515e">Attrib</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Team/Sponsors"><font color="#9e515e">Sponsors</font></a>
+
    <br>
+
  </div>
+
  <div class="col-lg-2" style="height:100%">
+
    <h3><font color="#7e1d2e">Project</font></h3>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Project/Background"><font color="#9e515e">Background</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Project/Sequence"><font color="#9e515e">Sequence</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Project/Circuit"><font color="#9e515e">Circuit</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Project/Organism"><font color="#9e515e">Organism</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Project/Nanopore"><font color="#9e515e">Nanopore</font></a>
+
    <br>
+
    <a class="footer-text" href="https://2015.igem.org/Team:Vanderbilt/Project/Achievements"><font color="#9e515e">Achievements</font></a>
+
    <br>
+
  </div>
+
  <div class="col-lg-2" style="height:100%">
+
    <h3><font color="#7e1d2e">Parts</font></h3>
+
 
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Parts/Part_Collection"><font color="#9e515e">Part Collection</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Parts/Optimized_RFPs"><font color="#9e515e">Optimized RFPs</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Parts/Visualizing_Evolution"><font color="#9e515e">Visualizing Evolution</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Parts/Repair Enzymes"><font color="#9e515e">Repair Enzymes</font></a>
+
    <br>
+
  </div>
+
  <div class="col-lg-2" style="height:100%">
+
    <h3><font color="#7e1d2e">Notebook</font></h3>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Notebook/May"><font color="#9e515e">May</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Notebook/June"><font color="#9e515e">June</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Notebook/July"><font color="#9e515e">July</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Notebook/August"><font color="#9e515e">Aug</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Notebook/September"><font color="#9e515e">Sept</font></a>
+
    <br>
+
  </div>
+
  <div class="col-lg-2" style="height:100%">
+
    <h3><font color="#7e1d2e">Practices</font></h3>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Practices/Safety"><font color="#9e515e">Safety</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Practices/Collaborations"><font color="#9e515e">Collabs</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Practices/Real_World_Applications"><font color="#9e515e">Real World Apps</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Practices/Interlab"><font color="#9e515e">Interlab</font></a>
+
    <br>
+
  </div>
+
  <div class="col-lg-2" style="height:100%">
+
    <h3><font color="#7e1d2e">Software</font></h3>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Software/Development"><font color="#9e515e">Development</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Software/User_Guide"><font color="#9e515e">User Guide</font></a>
+
    <br>
+
    <a href="https://2015.igem.org/Team:Vanderbilt/Software/Stats"><font color="#9e515e">Stats</font></a>
+
    <br>
+
  </div>
+
</div>
+
  <br>
+
 
</div>
 
</div>
  
<div class="col-lg-1 hidden-sm" style="height:100%;">
+
</html>
  <br>
+
{{Template:Vanderbilt_Footer}}
  <br>
+
<html>
  <div class="dnaStrand" alt="dna strand">
+
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+
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+
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+
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+
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+
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+
 
+
</div>
+
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+
  
 
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</html>

Latest revision as of 05:47, 21 November 2015

Vanderbilt iGEM 2015


Every sequence of DNA hides a secret. Concealed throughout any genetic construct are mutation hotspots - DNA motifs prone to high rates of mutation. Once a mutation occurs at one of these sites, a mutant may rapidly overtake the population due to evolutionary selective pressure.

Our team has compiled decades of research into an algorithm that is able to eliminate these hotspots, reducing the risk of mutation for any gene without altering its function. We have also devised strategies for improving the evolutionary stability of entire genetic circuits, and have created new bacterial strains with their genomes engineered to better resist and repair mutations.

Our foundational advance has the potential to revolutionize the way synthetic biologists optimize their genes, by looking beyond simple codon adaptation to consider the stability, safety, and reliability of DNA parts.

Join us as we expose the menaces lurking in your DNA. . .