Difference between revisions of "Team:Virginia/Team"

 
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<h1>Welcome to the University of Virginia iGEM 2015 Wiki</h1>
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<a href="http://virginia.edu">
<p>Use the navigation bar at the top of every page to move between pages. Please let us know if you have any comments or questions about our project by visiting the “Contact Us” page.</p>
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<p id="above-nav">University of Virginia iGEM 2015</p>
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width:32px;" src="/wiki/images/d/df/Virginia_rotunda2.png">
<div id="icon-box">
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</div></a>
<a href="https://twitter.com/Virginia_iGEM"><img id="twitter" src="/wiki/images/2/2c/Virginia_twitter_white.png"></img></a>
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                <p id="above-nav">University of Virginia iGEM 2015</p>
<a href="https://www.facebook.com/uvaigem"><img id="facebook" src="/wiki/images/e/ed/Virginia_facebook.png"></img></a>
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<li><a href="/Team:Virginia">Home</a></li>
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</ul>
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<li><a href="/Team:Virginia/Team">Team</a></li>
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<li><a href="/Team:Virginia/Project">Project</a></li>
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<li><a href="/Team:Virginia/Practices">Policy and Practices</a></li>
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<li><a href="/Team:Virginia/Attributions">Attributions</a></li>
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                        <li>
<li><a href="/Team:Virginia/Contact_us">Contact Us</a></li>
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                            <a href="/Team:Virginia">Home</a>
</ul>
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                        </li>
</div>
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                    </ul>
</div>
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                    <ul class="pull-right">
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                        <li>
<h2>
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                            <a href="/Team:Virginia/Team">Team</a>
House of Carbs
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                        </li>
<p>A Novel Solution to Minimizing Postprandial Hyperglycemic Spikes</p>
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                        <li>
</h2>
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                            <a href="/Team:Virginia/Project">Project</a>
</div>
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                        </li>
<div id="description-wrapper">
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                        <li>
<div id="description-text-wrapper">
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                            <a href="/Team:Virginia/Practices">Policy and Practices</a>
<h1>Project Overview</h1>
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                        </li>
<h3>The Problem: Diabetes Mellitus and Hyperglycemia</h3>
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                        <li>
<p>From diabetes mellitus a number of devastating complications, such as amputations, blindness, crippling neuropathies, and many others, can arise from increased blood sugar levels on a regular basis, but many of
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                            <a href="/Team:Virginia/Attributions">Attributions</a>
the major complications of diabetes arise from drastic fluctuations in the blood glucose
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                        </li>
level (Ceriello et al., 2012). Up to two-thirds of people with diabetes die of
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                        <li>
cardiovascular disease (CVD) brought about by diabetes-related macrovascular diseases
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                            <a href="/Team:Virginia/Contact_us">Contact Us</a>
(Deshpande et al. 2008). In fact, the risk for cardiovascular disease mortality is 2 to 4
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                        </li>
times higher in people with diabetes than in people who do not have diabetes.  
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                    </ul>
Additionally, diabetic retinopathy is the most common microvascular complication
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                </div>
among people with diabetes and results in more than 10,000 new cases of blindness per
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            </div>
year. Retinopathy is associated with prolonged hyperglycemia; it is slow to develop, and
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            <!-- POPUP SCRIPTS-->
there is some evidence that it can begin to develop as early as 7 years before clinical
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diagnosis of diabetes (Deshpande et al., 2008).</p>
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jQuery(document).ready(function(){
<p>Postprandial (post-meal) blood sugar spikes specifically are one of the most
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damaging complications of diabetes (Parkin et al., 2002). Many diabetics are able to
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effectively manage post-meal glycemic spikes with self-administered doses of insulin,
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but these hyperglycemic incidents still kill more Americans per year than any other
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diabetes-related complications (Parkin et al., 2002). Arguably, the gravest consequence of
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});
glycemic spikes in diabetes patients is the development of progressive macrovascular
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$("#popup-supraja").click(function(){
disease (MVD), which affects the large blood vessels of the body, hardening and
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blocking these vessels (Ceriello et al., 2012). MVD is the leading cause of death among
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});
T2DM patients in the United States, causing up to 65% of diabetes-related deaths, making it a huge target for diabetes treatments research (Deshpande et al., 2008). MVD
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also frequently leads to other severe complications such as ischemia in the extremities
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and blindness (Haffner et al., 1998).</p>
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});
<h3>Controlling Hyperglycemic Spikes</h3>
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$("#popup-dominic").click(function(){
<p>For many T1DM and T2DM patients, it has been shown that the regular
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control and management of blood glucose levels prevents many of the vascular
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complications of the disease, but most of the time control over glucose is difficult to
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attain because the self-dosing insulin treatment system that a lot of moderately to
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severely sick diabetes patients use is often hard to calibrate and use (Parkin et al., 2002).</p>
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<p>Compared to sucrose-rich food, starch-rich food has been found to create less
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$("#popup-jingyuan").click(function(){
fluctuation in blood glucose levels, and thus is beneficial to diabetes patients and
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hyperglycemia patients. There is evidence that this flatter response caused by a starch
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rich meal is associated with the slower rate of digestion of complex sugars versus simple
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$("#liam-box").click(function(){
sugars (Jenkins, Wolever, & Jenkins, 1988). Thus, if some of the simple sugars are first
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converted into complex saccharides inside the E. coli and then released back into small
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intestine, a similar flatter glycemic response will take place, which will be beneficial to
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});
the patients. </p>
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<h3>Our Devices</h3>
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<p> We have assembled one plasmid with genes that dictate a controllable level of simple sugars uptake and one plasmid to produce glucan and fructan from simple sugars and then lyse to release the complex sugars back into the environment. In essence, this microbial device runs on two genetic devices -- an uptake circuit and a polymeriztion circuit. </p>
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<p style="font-style:italic"> In order to learn more details, please visit the <a href="/Team:Virginia/Project">Project page.</a> </p>
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<div id="ref-button">
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<p>Show References</p>
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<p>Hide References</p>
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</div>
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<div id="ref-content">
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$("#issac-box").click(function(){
<p>A. Ceriello, S. Colagiuri, (2011). Guideline for management of postmeal glucose in  
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$("#popup-issac").fadeIn("medium");
diabetes. International Diabetes Federation Guideline Development Group,
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$("#popup-issac").css("top","800px");
http://www.idf.org/sites/default/files/postmeal%20glucose%20guidelines.pdf ,
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});
Accessed May. 6th, 2015
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$("#popup-issac").click(function(){
</p>
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$("#popup-issac").fadeOut("medium");
<p>American Diabetes Association (2014). National Diabetes Statistics Report.
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});
http://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf
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$("#sean-box").click(function(){
Accessed May. 5th, 2015
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$("#popup-sean").fadeIn("medium");
</p>
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$("#popup-sean").css("top","1100px");
<p>Anal, A. K., & Singh, H. (2007). Recent advances in microencapsulation of probiotics for
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});
industrial applications and targeted delivery. Trends in Food Science &
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$("#popup-sean").click(function(){
Technology, 18(5), 240–251. http://doi.org/10.1016/j.tifs.2007.01.004
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$("#popup-sean").fadeOut("medium");
</p>
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});
<p>Anan, F., Masaki, T., Eto, T., Fukunaga, N., Iwao, T., Kaneda, K., ... Yoshimatsu, H.
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$("#shiran-box").click(function(){
(2008). Postchallenge Plasma Glucose and Glycemic Spikes Are Associated with
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$("#popup-shiran").fadeIn("medium");
Pulse Pressure in Patients with Impaired Glucose Tolerance and Essential
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$("#popup-shiran").css("top","1100px");
Hypertension. Hypertension Research, 31(8), 1565–1571.
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});
http://doi.org/10.1291/hypres.31.1565
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$("#popup-shiran").click(function(){
</p>
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$("#popup-shiran").fadeOut("medium");
<p>AHFS Consumer Medication Information [Internet]. Bethesda (MD): American Society
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});
of Health-System Pharmacists, Inc.; ©2008. Acarbose; [revised 2015 Feb. 15;
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$("#connor-box").click(function(){
reviewed 2015 Apr. 28; cited 2015 May. 3]; Available from:
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$("#popup-connor").fadeIn("medium");
http://www.nlm.nih.gov/medlineplus/druginfo/meds/ a696015.html
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$("#popup-connor").css("top","1100px");
</p>
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});
<p>AHFS Consumer Medication Information [Internet]. Bethesda (MD): American Society
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$("#popup-connor").click(function(){
of Health-System Pharmacists, Inc.; ©2008. Pramlintide; [revised 2015 Feb. 15;
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$("#popup-connor").fadeOut("medium");
reviewed 2015 Apr. 28; cited 2015 May. 3]; Available from:
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});
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a605031.html
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});
</p>
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<p>Banguela, A., Arrieta, J. G., Rodríguez, R., Trujillo, L. E., Menéndez, C., & Hernández,
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</script>
L. (2011). High levan accumulation in transgenic tobacco plants expressing the  
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Gluconacetobacter diazotrophicus levansucrase gene. Journal of Biotechnology,  
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154(1), 93–98. http://doi.org/10.1016/j.jbiotec.2011.04.007
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</p>
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-supraja">
<p>Barr EL, Zimmet PZ, Welborn TA et al. (2007). "Risk of cardiovascular and all-cause
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                <div class="text-wrap">
mortality in individuals with diabetes mellitus, impaired fasting glucose, and
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                    <p>(click to close)</p>
impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study
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                    <img src="/wiki/images/1/10/Virginia_supraja2.jpg"></img>
(AusDiab)". Circulation 116 (2): 151–7.
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                    <h3>Supraja Chittari</h3>
</p>
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                    <h5>Poster and Presentation Coordinator & Biological Research Team Member</h5>
<p>Bernard, A. M., Anderson, L., Cook, C. B., & Phillips, L. S. (1999). What do internal
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                    <h4>Class of 2018 - College of Arts & Sciences, Undeclared</h4>
medicine residents need to enhance their diabetes care? Diabetes Care, 22(5),
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                    <p>Supraja Chittari is a rising second-year at the University of Virginia from Vienna, Virginia. Supraja can’t quite make up her mind about what she’s studying, but we know it’ll be something that’s fairly science-heavy. A dedicated member of iGEM 2015’s so-called BioSquad, she can be seen in the lab at ungodly hours of the night screaming something about failed competent cells.</p>
661–666. http://doi.org/10.2337/diacare.22.5.661
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                </div>
</p>
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            </div></a>
<p>Boada C, Martínez-Moreno J. Pathophysiology of diabetes mellitus type 2: beyond the
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duo "insulin resistance-secretion deficit.". Nutricion Hospitalaria [serial online].
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-dominic">
March 2, 2013;28:78-87. Available from: Fuente Académica, Ipswich, MA.
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                <div class="text-wrap">
Accessed April 16, 2015.
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                    <p>(click to close)</p>
</p>
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                    <img src="/wiki/images/6/6f/Virginia_dominic2.jpg"></img>
<p>B. Göke, H. F. (1995). Voglibose (AO128) Is an Efficient α-Glucosidase Inhibitor and  
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                    <h3>Dominic Ritchey</h3>
Mobilizes the Endogenous GLP-1 Reserve. Digestion, 56(6), 493–501.
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                    <h5>Wiki Programmer and Co-Chief Financial Officer</h5>
http://doi.org/10.1159/000201282
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                    <h4>Class of 2018 - School of Engineering and Applied Sciences, Computer Science & Biology</h4>
</p>
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                    <p> Dominic Ritchey is a rising second-year at the University of Virginia from Columbus, Ohio. Dominic is studying Computer Science and Biology because he has no idea yet what he wants to do with his life. Dominic is the Chief Financial Officer and Wiki Programmer for the team, so he has not even touched a pipette in the lab as of yet. Dominic is a dedicated member of the so-called Ca$hCrew, and he can often be found camped-out in a U.Va. library coding for hours on end. </p>
<p>Brown, J. B., Harris, S. B., Webster-Bogaert, S., Wetmore, S., Faulds, C., & Stewart, M.
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                </div>
(2002). The role of patient, physician and systemic factors in the management of  
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            </div></a>
type 2 diabetes mellitus. Family Practice, 19(4), 344–349.  
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http://doi.org/10.1093/fampra/19.4.344
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-jingyuan">
</p>
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                <div class="text-wrap">
<p>Butterworth, P. J., Warren, F. J., & Ellis, P. R. (2011). Human α-amylase and starch
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                    <p>(click to close)</p>
digestion: An interesting marriage. Starch - Stärke, 63(7), 395–405.
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                    <img src="/wiki/images/a/ac/Virginia_jingyuan2.jpg"></img>
http://doi.org/10.1002/star.201000150
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                    <h3>Jingyuan Zhang</h3>
</p>
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                    <h5>Laboratory Technician & Biological Research Team Member</h5>
<p>Centers for Disease Control and Prevention. (2014). National Diabetes Statistics Report.</p>
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                    <h4>Class of 2017 - School of Engineering and Applied Sciences, Biomedical Engineering</h4>
<p>Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., & Laakso, M. (2002).
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                    <p>Jingyuan Zhang is a rising third-year at the University of Virginia from Beijing, China, and she studies Biomedical Engineering. Jingyuan is a dedicated member of the BioSquad, and officially she is one of the team laboratory technicians. Jingyuan can frequently be found running hastily around the lab with multiple timers going off. </p>
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM
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                </div>
randomised trial. The Lancet, 359(9323), 2072–2077.
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            </div></a>
http://doi.org/10.1016/S0140-6736(02)08905-5
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</p>
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-liam">
<p>Chiasson, J.-L., Josse, R. G., Hunt, J. A., Palmason, C., Rodger, N. W., Ross, S. A., ...
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                <div class="text-wrap">
Wolever*, T. M. S. (1994). The Efficacy of Acarbose in the Treatment of Patients
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                    <p>(click to close)</p>
with Non–Insulin-Dependent Diabetes Mellitus: A Multicenter, Controlled
+
                    <img src="/wiki/images/1/1e/Virginia_liam2.jpg"></img>
Clinical Trial. Annals of Internal Medicine, 121(12), 928–935.  
+
                    <h3>Liam Wolf</h3>
http://doi.org/10.7326/0003-4819-121-12-199412150-00004
+
                    <h5>Administrator, Co-Chief Financial Officer and Policy & Practices Team Member</h5>
Crude and Age-Adjusted Rate per 100 of Civilian, Noninstitutionalized Population with
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                    <h4>Class of 2018 - School of Engineering and Applied Sciences, Systems Engineering</h4>
Diagnosed Diabetes, United States, 1980–2011. (2014, September 5). Retrieved
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                    <p>Liam Wolf is a rising second-year at the University of Virginia from Pittsburgh, Pennsylvania. Liam is studying Systems Engineering, even though no one really knows what that is. Liam is involved in just about everything the team does, whether he is asked or not, and the team lovingly (and mostly jokingly) refers to him as the Overlord. Officially, Liam is the team Administrator, though he is also involved in every other part of the project. Liam claims that, one day, all 9 team members will get together for a team-building activity, but no one really believes it. </p>
April 24, 2015, from
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                </div>
http://www.cdc.gov/diabetes/statistics/prev/national/figage.htm
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            </div></a>
</p>
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<p>Dedonder, R. 1966. Levansucrase from Bacillus subtilis. Methods Enzymol. 8:500–505.</p>
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-rena">
<p>Deshpande, A. D., Harris-Hayes, M., & Schootman, M. (2008). Epidemiology of diabetes
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                <div class="text-wrap">
and diabetes-related complications. Physical therapy, 88(11), 1254-1264.
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                    <p>(click to close)</p>
</p>
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                    <img src="/wiki/images/9/9d/Virginia_rena2.jpg"></img>
<p>D.M. Nathan, P.A. Cleary, J.Y. Backlund, S.M. Genuth, J.M. Lachin, T.J. Orchard, et al.,
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                    <h3>Rena Yuan</h3>
Intensive diabetes treatment and cardiovascular disease in patients with type 1
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                    <h5>Policy & Practices and Biology Research Team Member</h5>
diabetes, N Engl J Med, 353 (2005), pp. 2643–2653
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                    <h4>Class of 2018 - College of Arts and Sciences, Biology and Statistics</h4>
</p>
+
                    <p> Rena Yuan is a rising second-year at the University of Virginia studying biology and statistics. Rena is originally from Long Island, New York, but is now a NOVA (Northern Virginia) transplant. Rena is a dedicated member of the so-called BioSquad and though she works full-time in another position, she can frequently be seen coming into the lab at 4:00 am in order to get some of her work done, even when she knows that she’s not expected to do so.</p>
<p>D.R. Whiting, L. Guariguata, C. Weil, J. Shaw, IDF diabetes atlas: global estimates of the  
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                </div>
prevalence of diabetes for 2011 and 2030 Diabetes Res Clin Pract, 94 (2011), pp.  
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            </div></a>
311–321
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</p>
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-issac">
<p>Duncan, A. E. (2012). Hyperglycemia and Perioperative Glucose Management.Current
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                <div class="text-wrap">
Pharmaceutical Design, 18(38), 6195–6203.
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                    <p>(click to close)</p>
</p>
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                    <img src="/wiki/images/3/38/Virginia_issac2.jpg"></img>
<p>Edelman, P. S., Maier, H., & Wilhelm, K. (2012). Pramlintide in the Treatment of
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                    <h3>Issac Li</h3>
Diabetes Mellitus. BioDrugs, 22(6), 375–386. http://doi.org/10.2165/0063030-
+
                    <h5>Head of Modelling, Policy & Practices Team Member and Biology Research Team Member</h5>
200822060-00004
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                    <h4>Class of 2016 - School of Engineering and Applied Sciences, Biomedical Engineering</h4>
</p>
+
                    <p> Issac Li is a rising fourth-year at the University of Virginia studying Biomedical Engineering from Shijiazhuang, China. Issac is the official Head of Modeling for the 2015 team. Issac is a de facto addition to the BioSquad and also aids in Policy and Practices. </p>
<p>Ferraris, R. P., Yasharpour, S. A. S. A. N., Lloyd, K. C., Mirzayan, R. A. F. F. Y., &
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                </div>
Diamond, J. M. (1990). Luminal glucose concentrations in the gut under normal
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conditions. American Journal of Physiology-Gastrointestinal and Liver
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Physiology, 259(5), G822-G837.
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</p>
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<p>Gay, P., Le Coq, D., Steinmetz, M., Ferrari, E., & Hoch, J. A. (1983). Cloning structural
+
                    <p>(click to close)</p>
gene sacB, which codes for exoenzyme levansucrase of Bacillus subtilis:
+
                    <img src="/wiki/images/a/ad/Virginia_sean2.jpg"></img>
expression of the gene in Escherichia coli. Journal of bacteriology,153(3), 1424-
+
                    <h3>Sean Sequeira</h3>
1431.
+
                    <h5>Modelling Team Member, Policy and Practices Team Member, and Finance Team Member</h5>
</p>
+
                    <h4>Class of 2018 - School of Engineering and Applied Sciences, Biomedical Engineering</h4>
<p>Gray, G. M., & Ingelfinger, F. J. (1966). Intestinal absorption of sucrose in man:
+
                    <p>Sean Sequeira is a rising second-year studying Biomedical Engineering at the University of Virginia from Glen Allen, VA. He is a valued member of the Financial Team, the Modelling team, and the Policy and Practices team.   Sean can frequently be found working on probiotic research, figuring out sources for funding, or thinking of ways to make the Policy and Practices documentary Oscar worthy.</p>
interrelation of hydrolysis and monosaccharide product absorption. Journal of
+
                </div>
Clinical Investigation, 45(3), 388.
+
            </div></a>
</p>
+
            <!-- Shiran’s popup structural code-->
<p>Grant, R. W., Buse, J. B., & Meigs, J. B. (2005). Quality of Diabetes Care in U.S.
+
            <a href="javascript:void(0);"><div class="popup inactive" id="popup-shiran">
Academic Medical Centers Low rates of medical regimen change. Diabetes Care,  
+
                <div class="text-wrap">
28(2), 337–442. http://doi.org/10.2337/diacare.28.2.337
+
                    <p>(click to close)</p>
</p>
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                    <img src="/wiki/images/0/0f/Virginia_shiran2.jpg"></img>
<p>Grant, R. W., Pirraglia, P. A., Meigs, J. B., & Singer, D. E. (2004). Trends in complexity
+
                    <h3>Shiran Su</h3>
of diabetes care in the United States from 1991 to 2000. Archives of Internal
+
                    <h5>Laboratory Technician and Biological Research Team Member</h5>
Medicine, 164(10), 1134–1139. http://doi.org/10.1001/archinte.164.10.1134
+
                    <h4>Class of 2016 - School of Engineering and Applied Sciences, Biomedical Engineering</h4>
</p>
+
                    <p>Shiran Su is a rising fourth-year at the University of Virginia from Nanjing, China. Shiran is finishing up her degree in Biomedical Engineering this year. Shiran is a dedicated member of the so-called BioSquad. Without fail, one can either find Shiran somewhere in the building taking a quick daytime nap on a bench or lecturing another engineering teammate about the ease of the U.Va. engineering curriculum, especially after s/he has been complaining about a difficult class.</p>
<p>Halschou, K., Bukhave, K., & Rikardt, J. (2012). Intestinal Disaccharidase Activity and
+
                </div>
Uptake of Glucose from Sucrose. In S. Chackrewarthy (Ed.), Glucose Tolerance.
+
            </div></a>
InTech. Retrieved from http://www.intechopen.com/books/glucose-
+
            <!-- Connor’s popup structural code-->
tolerance/intestinal-disaccharidase-activity-and-uptake-of-glucose-from-sucrose
+
            <a href="javascript:void(0);"><div class="popup inactive" id="popup-connor">
</p>
+
                <div class="text-wrap">
<p>Hanahan, D. (1983). Studies on transformation of Escherichia coli with plasmids. Journal
+
                    <p>(click to close)</p>
of Molecular Biology, 166(4), 557–580.
+
                    <img src="/wiki/images/f/f3/Virginia_connor2.jpg"></img>
</p>
+
                    <h3>Connor Jahelka</h3>
<p>Hoffmann, J., & Spengler, M. (1997). Efficacy of 24-Week Monotherapy With Acarbose,
+
                    <h5>Head of Policy & Practices</h5>
Metformin, or Placebo in Dietary-Treated NIDDM Patients: The Essen-II Study.
+
                    <h4>Class of 2017 - College of Arts and Sciences, Biology </h4>
The American Journal of Medicine, 103(6), 483–490.
+
                    <p> Connor Jahelka is a rising third-year at the University of Virginia from Fairfax, Virginia. Connor is studying biology and splits his time between a neuroscience lab and iGEM during the summer. Connor is the Head of Policy and Practices for this year’s team. Connor has a notoriously faulty alarm clock, on which he blames his persistent lateness, and he works most effectively when given very detailed, itemized to-do lists and constant negative reinforcement, mostly provided by Liam.</p>
http://doi.org/10.1016/S0002-9343(97)00252-0
+
                </div>
Intensive blood-glucose control with sulphonylureas or insulin compared with
+
            </div></a>
conventional treatment and risk of complications in patients with type 2 diabetes
+
            <!-- END Pop-ups structural code -->
(UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.
+
            <div class="wrapper1">
</p>
+
                <div class="team_profile_link">
<p>Jenkins, D. J. A., Wolever, T. M. S., & Jenkins, A. L. (1988). Starchy Foods and  
+
                    <a href="https://igem.org/Team.cgi" >
Glycemic Index. Diabetes Care, 11(2), 149–159.
+
                        <div>
http://doi.org/10.2337/diacare.11.2.149
+
                            <img src="/wiki/images/1/10/Virginia_igem_logo.jpg"></img>
</p>
+
                        </div>
<p>Jones, M. C. (2007). Therapies for diabetes: pramlintide and exenatide. American Family
+
                        <div>
Physician, 75(12), 1831–1835.
+
                            <p>Official iGEM Team Profile</p>
</p>
+
                        </div>
<p>J Reizer, S. L. S. (1992). Functional interactions between proteins of the  
+
                    </a>
phosphoenolpyruvate:sugar phosphotransferase systems of Bacillus subtilis and
+
                </div>
Escherichia coli. The Journal of Biological Chemistry, 267(13), 9158–69.
+
                <div class="team_profile_link">
Jenkins, D. J., Wolever, T. M., & Jenkins, A. L. (1988). Starchy foods and glycemic
+
                    <a href="http://seas.virginia.edu/students/igem/" >
index. Diabetes care, 11(2), 149-159.
+
                        <div>
</p>
+
                            <img src="/wiki/images/a/a7/Virginia_rotunda.png"></img>
<p>Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Cotran, Ramzi S. ; Robbins, Stanley L.
+
                        </div>
(2005). Robbins and Cotran Pathologic Basis of Disease (7th ed.). Philadelphia,
+
                        <div>
Pa.: Saunders. pp. 1194–1195. ISBN 0-7216-0187-1. Lancet. 1998 Sep 12;
+
                            <p>Official U.Va. iGEM Website</p>
352(9131):837-53.
+
                        </div>
</p>
+
                    </a>
<p>Kundig, W., Ghosh, S., & Roseman, S. (1964). PHOSPHATE BOUND TO HISTIDINE
+
                </div>
IN A PROTEIN AS AN INTERMEDIATE IN A NOVEL PHOSPHO-
+
            </div>
TRANSFERASE SYSTEM. Proceedings of the National Academy of Sciences of
+
            <h1>University of Virginia 2015 iGEM Team Members</h1>
the United States of America, 52, 1067–1074.
+
            <p id="parenth">(click an image to learn more about any team member)</p>
</p>
+
            <!-- BEGIN Team photos structural code -->
<p>Lebovitz, H. E. (1997). ALPHA-GLUCOSIDASE INHIBITORS. Endocrinology and
+
            <div id="team-info">
Metabolism Clinics of North America, 26(3), 539–551.
+
                <div class="container">
http://doi.org/10.1016/S0889-8529(05)70266-8
+
                    <!--Supraja Chittari-->
</p>
+
                    <a href="javascript:void(0);"><div class="team-box" id="supraja-box">
<p>Lourens-Hattingh, A., & Viljoen, B. C. (2001). Yogurt as probiotic carrier food.
+
                        <img src="/wiki/images/0/06/Virginia_supraja.jpg">
International Dairy Journal, 11(1–2), 1–17. http://doi.org/10.1016/S0958-
+
                            <p>Supraja Chittari</p>
6946(01)00036-X
+
                        </img>
</p>
+
                    </div></a>
<p>Malagelada, J. R., Bazzoli, F., Elewaut, A., Fried, M., Krabshuis, J. H., Lindberg, G., ...
+
                    <!--Dominic Ritchey-->
Vakil, N. (2007). World Gastroenterology Organisation Practice Guidelines.
+
                    <a href="javascript:void(0);"><div class="team-box" id="dominic-box">
Dysphagia. Retrieved from http://almacen-
+
                        <img src="/wiki/images/a/af/Virginia_dominic.jpg">
gpc.dynalias.org/publico/Dysphagia%20WGO%202004%20Ingles.pdf
+
                            <p>Dominic Ritchey</p>
</p>
+
                        </img>
<p>Man, C. D., Camilleri, M., & Cobelli, C. (2006). A System Model of Oral Glucose
+
                    </div></a>
Absorption: Validation on Gold Standard Data. IEEE Transactions on Biomedical  
+
                    <!-- Jingyuan Zhang -->
Engineering, 53(12), 2472–2478. http://doi.org/10.1109/TBME.2006.883792
+
                    <a href="javascript:void(0);"><div class="team-box" id="jingyuan-box">
</p>
+
                        <img src="/wiki/images/3/37/Virginia_jingyuan.jpg">
<p>Meigs, J. B., Nathan, D. M., Wilson, P. W., Cupples, L. A., & Singer, D. E. (1998).
+
                            <p>Jingyuan Zhang</p>
Metabolic risk factors worsen continuously across the spectrum of nondiabetic
+
                        </img>
glucose tolerance. The Framingham Offspring Study. Annals of Internal Medicine,  
+
                    </div></a>
128(7), 524–533.
+
                    <!-- Liam Wolf -->
</p>
+
                    <a href="javascript:void(0);"><div class="team-box" id="liam-box">
<p>Narimasa, S., Tatsuo, H., Mitsutaka, Y., & Toshio, I. (1979). Action of human pancreatic
+
                        <img src="/wiki/images/e/ef/Virginia_liam.jpg">
and salivary α-amylases on maltooligosaccharides: Evaluation of kinetic
+
                            <p>Liam Wolf</p>
parameters. Clinica Chimica Acta, 97(2–3), 253–260.
+
                        </img>
http://doi.org/10.1016/0009-8981(79)90423-6
+
                    </div></a>
</p>
+
                    <!-- Rena Yuan -->
<p>National Diabetes Data Group. (1979). Classification and Diagnosis of Diabetes Mellitus
+
                    <a href="javascript:void(0);"><div class="team-box" id="rena-box">
and Other Categories of Glucose Intolerance. Diabetes, 28(12), 1039–1057.
+
                        <img src="/wiki/images/b/bd/Virginia_rena.jpg">
http://doi.org/10.2337/diab.28.12.1039
+
                            <p>Rena Yuan</p>
</p>
+
                        </img>
<p>Nissle, A. (1959). [Explanations of the significance of colonic dysbacteria & the
+
                    </div></a>
mechanism of action of E. coli therapy (mutaflor)]. Die Medizinische, 4(21),
+
                    <!-- Issac Li -->
1017–1022.
+
                    <a href="javascript:void(0);"><div class="team-box" id="issac-box">
</p>
+
                        <img src="/wiki/images/3/3b/Virginia_issac.jpg">
<p>Parkin, C. G., & Brooks, N. (2002). Is postprandial glucose control important? Is it
+
                            <p>Issac Li</p>
practical in primary care settings?. Clinical Diabetes, 20(2), 71-76.
+
                        </img>
</p>
+
                    </div></a>
<p>Patterson, Joan (2013). Many Schools Cutting Back on Physical Education. Las Vegas
+
                    <!-- Sean Sequeira -->
Review - Journal.
+
                    <a href="javascript:void(0);"><div class="team-box" id="sean-box">
Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S.
+
                        <img src="/wiki/images/8/8e/Virginia_sean.jpg">
adults. The Third National Health and Nutrition Examination Survey, 1988-1994.
+
                            <p>Sean Sequeira</p>
</p>
+
                        </img>
<p>Peng, C.-K., Buldyrev, S. V., Havlin, S., Simons, M., Stanley, H. E., & Goldberger, A. L.
+
                    </div></a>
(1994). Mosaic organization of DNA nucleotides. Physical Review E, 49(2),
+
                    <!-- Shiran Su -->
1685–1689. http://doi.org/10.1103/PhysRevE.49.1685
+
                    <a href="javascript:void(0);"><div class="team-box" id="shiran-box">
</p>
+
                        <img src="/wiki/images/8/8b/Virginia_shiran.jpg">
<p>Rathmann, W., & Giani, G. (2004). Global Prevalence of Diabetes: Estimates for the
+
                            <p>Shiran Su</p>
Year 2000 and Projections for 2030: Response to Wild et al. Diabetes Care, 2568-
+
                        </img>
2569.
+
                    </div></a>
</p>
+
                    <!-- Connor Jahelka -->
<p>Recorbet, G. H. I. S. L. A. I. N. E., Robert, C., Givaudan, A., Kudla, B., Normand, P., &
+
                    <a href="javascript:void(0);"><div class="team-box" id="connor-box">
Faurie, G. (1993). Conditional suicide system of Escherichia coli released into
+
                        <img src="/wiki/images/0/03/Virginia_connor.jpg">
soil that uses the Bacillus subtilis sacB gene. Applied and environmental
+
                            <p>Connor Jahelka</p>
microbiology, 59(5), 1361-1366.
+
                        </img>
</p>
+
                    </div></a>
<p>Ried, J. L., and A. Collmer. 1987. An nptI-sacB-sacR cartridge for constructing directed,
+
                </div>
unmarked mutations in Gram-negative bacteria by marker exchange-eviction
+
            </div>
mutagenesis. Gene 57:239–246.
+
            <!-- SPECIFIC STRUCTURAL CODE ENDS HERE -->
</p>
+
            <footer>
<p>Riddle, M., Frias, J., Zhang, B., Maier, H., Brown, C., Lutz, K., & Kolterman, O. (2007).
+
                <div id="foot-img">
Pramlintide Improved Glycemic Control and Reduced Weight in Patients With
+
                    <img src="https://static.igem.org/mediawiki/2015/d/d1/Virginia_logo4.png"></img>
Type 2 Diabetes Using Basal Insulin. Diabetes Care, 30(11), 2794–2799.
+
                </div>
http://doi.org/10.2337/dc07-0589
+
                <div id="foot-text">
</p>
+
                    <p>University of Virginia iGEM</p>
<p>Saydah, S. H., Miret, M., Sung, J., Varas, C., Gause, D., & Brancati, F. L. (2001).
+
                    <p>148 Gilmer Hall</p>
Postchallenge Hyperglycemia and Mortality in a National Sample of U.S. Adults.
+
                    <p>485 McCormick Road</p>
Diabetes Care, 24(8), 1397–1402. http://doi.org/10.2337/diacare.24.8.1397
+
                    <p>Charlottesville, Virginia 22904</p>
</p>
+
                    <p>United States of America</p>
<p>Snelling, Anatasia; Korba, Casey; Burkey, Alyvia (2007). The National School Lunch
+
                    <p>
and Competitive Food Offerings and Purchasing Behaviors of High School
+
                        <a href="mailto:virginia.igem@gmail.com">
Students, 77(10), 701-705.
+
</p>
+
<p>Sonnenborn, Ulrich; Schulze, Jurgen. 2009. The Non-Pathogenic Escherichia coli strain
+
Nissle 1917 - Features of a Versatile Probiotic. Microbial Ecology in Health and
+
Disease, (21), 122-158.
+
</p>
+
<p>S.M. Haffner, S. Lehto, T. Ronnemaa, K. Pyorala, M. Laakso, Mortality from coronary
+
heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and
+
without prior myocardial infarction, N Engl J Med, 339 (1998), pp. 229–234
+
</p>
+
<p>Schultz, M. (2008). Clinical use of E. coli Nissle 1917 in inflammatory bowel disease.
+
Inflammatory Bowel Diseases, 14(7), 1012–1018.
+
http://doi.org/10.1002/ibd.20377
+
</p>
+
<p>Seifter, S., & Dayton, S. (1950). The estimation of glycogen with the anthrone reagent.
+
Archives of Biochemistry, 25(1), 191–200.
+
</p>
+
<p>Shulman, N. B., Martinez, B., Brogan, D., Carr, A. A., & Miles, C. G. (1986). Financial
+
cost as an obstacle to hypertension therapy. American Journal of Public Health,
+
76(9), 1105–1108.
+
</p>
+
<p>Suwattee, P., Lynch, J. C., & Pendergrass, M. L. (2003). Quality of Care for Diabetic
+
Patients in a Large Urban Public Hospital. Diabetes Care, 26(3), 563–568.
+
http://doi.org/10.2337/diacare.26.3.563
+
</p>
+
<p>Temelkova-Kurktschiev, T. S., Koehler, C., Henkel, E., Leonhardt, W., Fuecker, K., &
+
Hanefeld, M. (2000). Postchallenge plasma glucose and glycemic spikes are more
+
strongly associated with atherosclerosis than fasting glucose or HbA1c level.
+
</p>
+
<p>Diabetes Care, 23(12), 1830–1834. http://doi.org/10.2337/diacare.23.12.1830
+
What are normal blood glucose levels? Retrieved from Virginia Mason Medical Center
+
website: https://www.virginiamason.org/whatarenormalbloodglucoselevels.
+
Accessed: May. 5th ,2015
+
</p>
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<p>University of Virginia iGEM</p>
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}
+
#description-text-wrapper p:last-child {
+
font-style:italic;
+
}
+
#description-wrapper h1 {
+
font-size: 26px;
+
font-family:Arial;
+
color:#fff;
+
font-weight:bold;
+
}
+
 
footer div img {
 
footer div img {
 
width:auto;
 
width:auto;
Line 464: Line 332:
 
}
 
}
 
footer div:first-child {  
 
footer div:first-child {  
 +
background-image:url(‘https://encrypted-tbn3.gstatic.com/images?q=tbn:ANd9GcQUA5CF2C_kOVnWjyl62TA17VNs6RSsPIkrCejlLbtZ7rAVgzQxOQ’);
 
float:right;
 
float:right;
 
top:10px;
 
top:10px;
Line 471: Line 340:
 
display:inline;
 
display:inline;
 
overflow:hidden;
 
overflow:hidden;
}
 
.jumbotron {
 
height: auto;
 
background-size: 100%;
 
background-image: url("https://static.igem.org/mediawiki/2015/b/b8/Virginia_cells.jpg");
 
padding:60px;
 
margin:0px 0px 0px 0px;
 
color:white;
 
opacity:0.9;
 
}
 
.jumbotron h2 {
 
text-align:center;
 
color:#ffffff;
 
font-size:70px;
 
font-weight:bold;
 
padding-bottom:30px;
 
margin-bottom:0px;
 
width:50%;
 
opacity:1;
 
margin-left:25%;
 
background-color:#007bb6;
 
border-radius:30px;
 
text-shadow:2px 2px 2px black;
 
box-shadow: 5px 5px 10px #191919;
 
}
 
.jumbotron h1 {
 
color: #fff;
 
opacity:1;
 
font-size: 48px; 
 
font-weight: bold;
 
text-align:center;
 
padding-bottom:20px;
 
}
 
.learn-more {
 
width:100%;
 
background-color:#000000;
 
text-align:center;
 
}
 
.learn-more .container .row {
 
padding-bottom: 20px;
 
padding-top:30px;
 
}
 
.learn-more h3 {
 
font-family: 'Shift', sans-serif;
 
font-size: 18px;
 
font-weight: bold;
 
text-align:center;
 
}
 
.learn-more a {
 
color:#007bb6;
 
}
 
.learn-more img {
 
width: 90%;
 
height: auto;
 
border-radius:20%;
 
box-shadow: 5px 5px 2px #888888;
 
 
}
 
}
 
.nav {
 
.nav {
Line 551: Line 364:
 
border-radius:5px;
 
border-radius:5px;
 
}
 
}
 +
#top_menu_14 {
 +
border: 0px;
 +
}
 
.nav a:hover{
 
.nav a:hover{
 
color:#fff;
 
color:#fff;
Line 566: Line 382:
 
.row {
 
.row {
 
width:100%;
 
width:100%;
 +
}
 +
h1 {
 +
text-align:center;
 +
color:white;
 +
font-size:40px;
 +
font-family:Arial;
 +
padding-top:20px;
 +
padding-bottom:20px;
 +
font-weight:bold;
 
}
 
}
 
#content h1.firstHeading {
 
#content h1.firstHeading {
Line 582: Line 407:
 
font-family: Century Gothic, sans-serif;
 
font-family: Century Gothic, sans-serif;
 
}
 
}
#top_menu_14 {
+
/*BORDER ATTRIBUTES*/
+
border-top:5px solid #007bb6;
+
background-color: #003F87;
+
border-color:#003F87;
+
}
+
#top_menu_14 li.has_submenu:hover {
+
opacity:1.0;
+
background-color:#007bb6;
+
text-decoration:none;
+
}
+
#top_menu_14 li:hover {
+
opacity:1.0;
+
background-color:#007bb6;
+
text-decoration:none;
+
}
+
 
footer {
 
footer {
 
width:100%
 
width:100%
Line 604: Line 415:
 
background:#000000;
 
background:#000000;
 
clear:both;
 
clear:both;
 +
border-top:5px solid #007bb6;
 
}
 
}
 
footer p:first-child {
 
footer p:first-child {
Line 613: Line 425:
 
footer a {
 
footer a {
 
color:#fff;
 
color:#fff;
 +
text-decoration:underline;
 
}
 
}
 
footer p {
 
footer p {
 
width:auto;
 
width:auto;
 +
font-size:10px;
 
}
 
}
 
p {  
 
p {  
Line 632: Line 446:
 
text-align:center;
 
text-align:center;
 
font-family:Helvetica;
 
font-family:Helvetica;
text-transform:uppercase;
 
 
text-shadow: 2px 2px #007bb6;
 
text-shadow: 2px 2px #007bb6;
padding-left:25%;
+
padding-left:30%;
 
}
 
}
 
#top-part a {
 
#top-part a {
Line 671: Line 484:
 
padding-top:15px;
 
padding-top:15px;
 
}
 
}
.box{
+
/* OTHER STYLE CODE GOES BELOW HERE */
width:60%;
+
.team-box{
height:100px;
+
width:30%;
 +
height:400px;
 
display:inline-block;
 
display:inline-block;
margin-left:20%;
+
margin-left:1.5%;
 
margin-top:25px;
 
margin-top:25px;
 
margin-bottom:10px;
 
margin-bottom:10px;
Line 682: Line 496:
 
overflow:hidden;
 
overflow:hidden;
 
background-color:#003F87;
 
background-color:#003F87;
float:left;
 
 
}
 
}
.box:hover{
+
.team-box:hover{
 
box-shadow: 5px 5px 10px #555555;
 
box-shadow: 5px 5px 10px #555555;
 
}
 
}
.box img {
+
.team-box img {
margin:50px;
+
width:100%;
width:70%;
+
 
height:auto;
 
height:auto;
margin-left:15%;
+
border-bottom: 5px solid #007bb6;
display:none;
+
border-radius:10px;
+
box-shadow:none;
+
drop-shadow:none;
+
 
}
 
}
.box p {
+
.team-box p {
 
font-family:Arial;
 
font-family:Arial;
font-size:30px;
+
font-size:26px;
 
font-weight:bold;
 
font-weight:bold;
padding-top:25px;
+
padding-top:10px;
 +
padding-bottom:10px;
 
text-align:center;
 
text-align:center;
 
}
 
}
 +
/* Pop-ups style code */
 
.popup {
 
.popup {
background:#000000;
+
width:80%;
width:60%;
+
position:fixed;
+
top:200px;
+
margin-left:20%;
+
 
height:auto;
 
height:auto;
border-radius:15px;
+
background-color:#191919;
border:5px solid #007bb6;
+
border-radius:30px;
box-shadow: 5px 5px 10px #191919;
+
position:absolute;
 +
top:500px;
 +
left:10%;
 +
z-index:5;
 +
border: 10px solid #007bb6;
 +
box-shadow: 10px 10px 20px black;
 
}
 
}
.popup h1 {
+
.text-wrap {
font-size:50px;
+
padding:20px 20px 20px 20px;
font-weight:bold;
+
}
width:90%;
+
.text-wrap h3 {
margin-left:5%;
+
 
text-align:center;
 
text-align:center;
font-family:Arial;
+
font-weight:bold;
color:#fff;
+
text-shadow:2px 2px 1px #007bb6;
padding:30px;
+
color:white;
background:#F59A2C;
+
margin-bottom:30px;
text-shadow: 2px 2px 4px #000000;
+
font-size:30px;
border: none;
+
border-radius:20px;
+
 
}
 
}
.popup p{
+
.text-wrap h5{
font-size:17px;
+
margin-bottom:10px;
color:#fff;
+
font-weight:bold;
padding:10px;
+
font-size:25px;
 
text-align:center;
 
text-align:center;
font-family:Arial;
+
font-weight:bold;
 +
color:white;
 
}
 
}
.popup p:last-child {
+
.text-wrap h4 {
font-size:10px;
+
text-align:center;
 +
font-weight:bold;
 
color:#fff;
 
color:#fff;
width:80%;
+
padding-bottom:25px;
margin-left:10%;
+
}
 +
.text-wrap img {
 +
width:30%;
 +
margin-left:35%;
 
height:auto;
 
height:auto;
text-align:center;
+
border-radius:15px;
 +
border: 5px solid #fff;
 
}
 
}
.jumbotron p {
+
.active {
font-family:Arial;
+
display:block;
font-size:26px;
+
padding:5%;
+
 
}
 
}
#ref-button, #ref-button2 {
+
.inactive {
width:25%;
+
display:none;
padding:10px;
+
height:auto;
+
float:right;
+
border-radius:10px;
+
margin-right:15%;
+
background:#007bb6;
+
border:5px solid white;
+
margin-top:30px;
+
margin-bottom:30px;
+
 
}
 
}
#ref-button a, #ref-button2 a {
+
.team_profile_link{
width:100%;
+
width:30%;
height:100%;
+
margin-left:15%;
 +
background-color:#007bb6;
 +
border: 3px solid #fff;
 +
border-radius: 10px;
 +
            margin-top:25px;
 +
    padding: 5px 5px 5px 5px;
 +
display:inline-block;
 
}
 
}
#ref-button p, #ref-button2 p {
+
.team_profile_link div {
font-size:20px;
+
display: inline;
color:#fff;
+
font-family:Arial;
+
text-align:center;
+
 
}
 
}
#ref-button2{
+
.team_profile_link:hover {
display:none;
+
background-color:#0276FD;
float:left;
+
margin-left:15%;
+
 
}
 
}
.active {
+
.team_profile_link img {
//display:block;
+
width:40%;
 +
margin-left:30%;
 +
height:auto;
 +
border-radius:50%;
 +
border:3px solid #63D1F4;
 +
background:white;
 
}
 
}
#ref-content{
+
.team_profile_link p {
display:none;
+
font-family: Arial;
 +
font-weight:bold;
 +
font-size: 18px;
 +
text-align:center;
 
}
 
}
#description-wrapper h3 {
+
.wrapper1 div:last-child{
color: #fff;
+
margin-left:10%;
border-bottom:1px dotted #007bb6;
+
 
}
 
}
 +
#parenth{
 +
font-size:12px;
 +
text-align:center;
 +
font-family:Arial;
 +
}
 +
            .text-wrap p{
 +
            font-size:20px;
 +
            font-family:Arial;
 +
width:70%;
 +
margin-left:15%;
 +
border-top: 1px dotted white;
 +
padding-top: 15px;
 +
color:#87CEFA;
 +
            }
 +
.text-wrap p:first-child{
 +
width:95%;
 +
color:white;
 +
margin-left:2.5%;
 +
font-size:16px;
 +
}
 +
/* SPECIFIC STYLE CODE ENDS HERE */
 
</style>
 
</style>
<script type="text/javascript">
+
        </body>
jQuery(document).ready(function(){
+
    </html>
$(".popup").css("z-index","11");
+
$(".back").css("opacity",".3");
+
$("#top_menu_14").css("opacity",".3");
+
$(".popup").css("opacity","1");
+
$(".popup").click(function(){
+
$(".popup").fadeOut("slow");
+
$("*").css("opacity","1");
+
});
+
$(".box").mouseenter(function(){
+
$(this).css("width","80%");
+
$(this).css("margin-left","10%");
+
$("img", this).css("display","block");
+
$(this).css("height","auto");
+
});
+
$(".box").mouseleave(function(){
+
$(this).css("width","60%");
+
$(this).css("margin-left","20%");
+
$(this).css("height","100px");
+
$("img", this).css("display","none");
+
});
+
});
+
</script>
+
</body>
+
</html>
+

Latest revision as of 20:33, 18 September 2015

University of Virginia iGEM 2015

University of Virginia 2015 iGEM Team Members

(click an image to learn more about any team member)

University of Virginia iGEM

148 Gilmer Hall

485 McCormick Road

Charlottesville, Virginia 22904

United States of America

virginia.igem@gmail.com