Difference between revisions of "Team:Virginia/Team"

 
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<h1>Welcome to the University of Virginia iGEM 2015 Wiki</h1>
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<a href="http://virginia.edu">
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<p>Use the navigation bar at the top of every page to move between pages. Please let us know if you have any comments or questions about our project by visiting the “Contact Us” page.</p>
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<p id="above-nav">University of Virginia iGEM 2015</p>
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width:32px;" src="/wiki/images/d/df/Virginia_rotunda2.png">
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                <p id="above-nav">University of Virginia iGEM 2015</p>
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<li><a href="/Team:Virginia">Home</a></li>
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<li><a href="/Team:Virginia/Team">Team</a></li>
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<li><a href="/Team:Virginia/Project">Project</a></li>
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<li><a href="/Team:Virginia/Practices">Policy and Practices</a></li>
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<li><a href="/Team:Virginia/Attributions">Attributions</a></li>
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                        <li>
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<li><a href="/Team:Virginia/Contact_us">Contact Us</a></li>
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                            <a href="/Team:Virginia">Home</a>
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<h2>
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                            <a href="/Team:Virginia/Team">Team</a>
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House of Carbs
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                        </li>
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<p>A Novel Solution to Minimizing Postprandial Hyperglycemic Spikes</p>
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                        <li>
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</h2>
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                            <a href="/Team:Virginia/Project">Project</a>
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                        </li>
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<div id="description-wrapper">
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                        <li>
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<div id="description-text-wrapper">
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                            <a href="/Team:Virginia/Practices">Policy and Practices</a>
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<h1>Project Overview</h1>
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                        </li>
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<h3>The Problem: Diabetes Mellitus and Hyperglycemia</h3>
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                        <li>
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<div class="minimize" id="min1">
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                            <a href="/Team:Virginia/Attributions">Attributions</a>
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<p>SHOW LESS</p>
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                        <li>
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<div class="maximize" id="max1">
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                            <a href="/Team:Virginia/Contact_us">Contact Us</a>
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<p>SHOW MORE</p>
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                        </li>
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                    </ul>
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<p>From diabetes mellitus a number of devastating complications, such as amputations, blindness, crippling neuropathies, and many others, can arise from increased blood sugar levels on a regular basis, but many of
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the major complications of diabetes arise from drastic fluctuations in the blood glucose
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level (Ceriello et al., 2012). Up to two-thirds of people with diabetes die of
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cardiovascular disease (CVD) brought about by diabetes-related macrovascular diseases
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(Deshpande et al. 2008). In fact, the risk for cardiovascular disease mortality is 2 to 4
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times higher in people with diabetes than in people who do not have diabetes.  
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Additionally, diabetic retinopathy is the most common microvascular complication
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among people with diabetes and results in more than 10,000 new cases of blindness per
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year. Retinopathy is associated with prolonged hyperglycemia; it is slow to develop, and
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there is some evidence that it can begin to develop as early as 7 years before clinical
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diagnosis of diabetes (Deshpande et al., 2008).
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</p>
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<p>Postprandial (post-meal) blood sugar spikes specifically are one of the most
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damaging complications of diabetes (Parkin et al., 2002). Many diabetics are able to
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effectively manage post-meal glycemic spikes with self-administered doses of insulin,
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but these hyperglycemic incidents still kill more Americans per year than any other
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diabetes-related complications (Parkin et al., 2002). Arguably, the gravest consequence of
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glycemic spikes in diabetes patients is the development of progressive macrovascular
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disease (MVD), which affects the large blood vessels of the body, hardening and
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blocking these vessels (Ceriello et al., 2012). MVD is the leading cause of death among
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T2DM patients in the United States, causing up to 65% of diabetes-related deaths, making it a huge target for diabetes treatments research (Deshpande et al., 2008). MVD
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also frequently leads to other severe complications such as ischemia in the extremities
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and blindness (Haffner et al., 1998).
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<h3>Controlling Hyperglycemic Spikes</h3><div id="des2">
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<p>For many T1DM and T2DM patients, it has been shown that the regular
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control and management of blood glucose levels prevents many of the vascular
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complications of the disease, but most of the time control over glucose is difficult to
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attain because the self-dosing insulin treatment system that a lot of moderately to
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severely sick diabetes patients use is often hard to calibrate and use (Parkin et al., 2002).
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</p>
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<p>Compared to sucrose-rich food, starch-rich food has been found to create less
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fluctuation in blood glucose levels, and thus is beneficial to diabetes patients and
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hyperglycemia patients. There is evidence that this flatter response caused by a starch
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rich meal is associated with the slower rate of digestion of complex sugars versus simple
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sugars (Jenkins, Wolever, & Jenkins, 1988). Thus, if some of the simple sugars are first
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converted into complex saccharides inside the E. coli and then released back into small
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intestine, a similar flatter glycemic response will take place, which will be beneficial to
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the patients.
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</p></div>
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<h3>Our Devices</h3><div id="des3">
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<p> We have assembled one plasmid with genes that dictate a controllable level of simple sugars uptake and one plasmid to produce glucan and fructan from simple sugars and then lyse to release the complex sugars back into the environment. In essence, this microbial device runs on two genetic devices -- an uptake circuit and a polymeriztion circuit. </p></div>
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<p style="font-style:italic"> In order to learn more details, please visit the <a href="/Team:Virginia/Project">Project page.</a> </p>
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<p>A. Ceriello, S. Colagiuri, (2011). Guideline for management of postmeal glucose in
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diabetes. International Diabetes Federation Guideline Development Group,
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</script>
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http://www.idf.org/sites/default/files/postmeal%20glucose%20guidelines.pdf ,
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Accessed May. 6th, 2015
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            <!-- Pop-ups structural code -->
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</p>
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<p>American Diabetes Association (2014). National Diabetes Statistics Report.
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-supraja">
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http://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf
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                <div class="text-wrap">
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Accessed May. 5th, 2015
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                    <p>(click to close)</p>
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</p>
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                    <img src="/wiki/images/1/10/Virginia_supraja2.jpg"></img>
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<p>Anal, A. K., & Singh, H. (2007). Recent advances in microencapsulation of probiotics for
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                    <h3>Supraja Chittari</h3>
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industrial applications and targeted delivery. Trends in Food Science &  
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                    <h5>Poster and Presentation Coordinator & Biological Research Team Member</h5>
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Technology, 18(5), 240–251. http://doi.org/10.1016/j.tifs.2007.01.004
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                    <h4>Class of 2018 - College of Arts & Sciences, Undeclared</h4>
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</p>
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                    <p>Supraja Chittari is a rising second-year at the University of Virginia from Vienna, Virginia. Supraja can’t quite make up her mind about what she’s studying, but we know it’ll be something that’s fairly science-heavy. A dedicated member of iGEM 2015’s so-called BioSquad, she can be seen in the lab at ungodly hours of the night screaming something about failed competent cells.</p>
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<p>Anan, F., Masaki, T., Eto, T., Fukunaga, N., Iwao, T., Kaneda, K., ... Yoshimatsu, H.
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                </div>
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(2008). Postchallenge Plasma Glucose and Glycemic Spikes Are Associated with
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            </div></a>
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Pulse Pressure in Patients with Impaired Glucose Tolerance and Essential
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            <!-- Dominic’s popup structural code-->
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Hypertension. Hypertension Research, 31(8), 1565–1571.  
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-dominic">
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http://doi.org/10.1291/hypres.31.1565
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                <div class="text-wrap">
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</p>
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                    <p>(click to close)</p>
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<p>AHFS Consumer Medication Information [Internet]. Bethesda (MD): American Society
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                    <img src="/wiki/images/6/6f/Virginia_dominic2.jpg"></img>
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of Health-System Pharmacists, Inc.; ©2008. Acarbose; [revised 2015 Feb. 15;  
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                    <h3>Dominic Ritchey</h3>
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reviewed 2015 Apr. 28; cited 2015 May. 3]; Available from:
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                    <h5>Wiki Programmer and Co-Chief Financial Officer</h5>
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http://www.nlm.nih.gov/medlineplus/druginfo/meds/ a696015.html
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                    <h4>Class of 2018 - School of Engineering and Applied Sciences, Computer Science & Biology</h4>
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</p>
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                    <p> Dominic Ritchey is a rising second-year at the University of Virginia from Columbus, Ohio. Dominic is studying Computer Science and Biology because he has no idea yet what he wants to do with his life. Dominic is the Chief Financial Officer and Wiki Programmer for the team, so he has not even touched a pipette in the lab as of yet. Dominic is a dedicated member of the so-called Ca$hCrew, and he can often be found camped-out in a U.Va. library coding for hours on end. </p>
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<p>AHFS Consumer Medication Information [Internet]. Bethesda (MD): American Society
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                </div>
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of Health-System Pharmacists, Inc.; ©2008. Pramlintide; [revised 2015 Feb. 15;
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            </div></a>
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reviewed 2015 Apr. 28; cited 2015 May. 3]; Available from:
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            <!-- Jingyuan’s popup structural code-->
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http://www.nlm.nih.gov/medlineplus/druginfo/meds/a605031.html
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-jingyuan">
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</p>
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                <div class="text-wrap">
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<p>Banguela, A., Arrieta, J. G., Rodríguez, R., Trujillo, L. E., Menéndez, C., & Hernández,
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                    <p>(click to close)</p>
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L. (2011). High levan accumulation in transgenic tobacco plants expressing the
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                    <img src="/wiki/images/a/ac/Virginia_jingyuan2.jpg"></img>
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Gluconacetobacter diazotrophicus levansucrase gene. Journal of Biotechnology,  
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                    <h3>Jingyuan Zhang</h3>
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154(1), 93–98. http://doi.org/10.1016/j.jbiotec.2011.04.007
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                    <h5>Laboratory Technician & Biological Research Team Member</h5>
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</p>
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                    <h4>Class of 2017 - School of Engineering and Applied Sciences, Biomedical Engineering</h4>
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<p>Barr EL, Zimmet PZ, Welborn TA et al. (2007). "Risk of cardiovascular and all-cause
+
                    <p>Jingyuan Zhang is a rising third-year at the University of Virginia from Beijing, China, and she studies Biomedical Engineering. Jingyuan is a dedicated member of the BioSquad, and officially she is one of the team laboratory technicians. Jingyuan can frequently be found running hastily around the lab with multiple timers going off. </p>
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mortality in individuals with diabetes mellitus, impaired fasting glucose, and  
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                </div>
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impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study
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            </div></a>
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(AusDiab)". Circulation 116 (2): 151–7.
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</p>
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-liam">
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<p>Bernard, A. M., Anderson, L., Cook, C. B., & Phillips, L. S. (1999). What do internal
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                <div class="text-wrap">
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medicine residents need to enhance their diabetes care? Diabetes Care, 22(5),
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                    <p>(click to close)</p>
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661–666. http://doi.org/10.2337/diacare.22.5.661
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                    <img src="/wiki/images/1/1e/Virginia_liam2.jpg"></img>
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</p>
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                    <h3>Liam Wolf</h3>
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<p>Boada C, Martínez-Moreno J. Pathophysiology of diabetes mellitus type 2: beyond the
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                    <h5>Administrator, Co-Chief Financial Officer and Policy & Practices Team Member</h5>
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duo "insulin resistance-secretion deficit.". Nutricion Hospitalaria [serial online].
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                    <h4>Class of 2018 - School of Engineering and Applied Sciences, Systems Engineering</h4>
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March 2, 2013;28:78-87. Available from: Fuente Académica, Ipswich, MA.
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                    <p>Liam Wolf is a rising second-year at the University of Virginia from Pittsburgh, Pennsylvania. Liam is studying Systems Engineering, even though no one really knows what that is. Liam is involved in just about everything the team does, whether he is asked or not, and the team lovingly (and mostly jokingly) refers to him as the Overlord. Officially, Liam is the team Administrator, though he is also involved in every other part of the project. Liam claims that, one day, all 9 team members will get together for a team-building activity, but no one really believes it. </p>
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Accessed April 16, 2015.
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                </div>
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</p>
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            </div></a>
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<p>B. Göke, H. F. (1995). Voglibose (AO128) Is an Efficient α-Glucosidase Inhibitor and
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Mobilizes the Endogenous GLP-1 Reserve. Digestion, 56(6), 493–501.
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-rena">
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http://doi.org/10.1159/000201282
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                <div class="text-wrap">
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</p>
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                    <p>(click to close)</p>
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<p>Brown, J. B., Harris, S. B., Webster-Bogaert, S., Wetmore, S., Faulds, C., & Stewart, M.
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                    <img src="/wiki/images/9/9d/Virginia_rena2.jpg"></img>
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(2002). The role of patient, physician and systemic factors in the management of
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                    <h3>Rena Yuan</h3>
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type 2 diabetes mellitus. Family Practice, 19(4), 344–349.
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                    <h5>Policy & Practices and Biology Research Team Member</h5>
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http://doi.org/10.1093/fampra/19.4.344
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                    <h4>Class of 2018 - College of Arts and Sciences, Biology and Statistics</h4>
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</p>
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                    <p> Rena Yuan is a rising second-year at the University of Virginia studying biology and statistics. Rena is originally from Long Island, New York, but is now a NOVA (Northern Virginia) transplant. Rena is a dedicated member of the so-called BioSquad and though she works full-time in another position, she can frequently be seen coming into the lab at 4:00 am in order to get some of her work done, even when she knows that she’s not expected to do so.</p>
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<p>Butterworth, P. J., Warren, F. J., & Ellis, P. R. (2011). Human α-amylase and starch
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                </div>
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digestion: An interesting marriage. Starch - Stärke, 63(7), 395–405.
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            </div></a>
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http://doi.org/10.1002/star.201000150
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</p>
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            <a href="javascript:void(0);"><div class="popup inactive" id="popup-issac">
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<p>Centers for Disease Control and Prevention. (2014). National Diabetes Statistics Report.</p>
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<p>Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., & Laakso, M. (2002).
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                    <p>(click to close)</p>
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Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM
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                    <img src="/wiki/images/3/38/Virginia_issac2.jpg"></img>
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randomised trial. The Lancet, 359(9323), 2072–2077.  
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                    <h3>Issac Li</h3>
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http://doi.org/10.1016/S0140-6736(02)08905-5
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                    <h5>Head of Modelling, Policy & Practices Team Member and Biology Research Team Member</h5>
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</p>
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                    <h4>Class of 2016 - School of Engineering and Applied Sciences, Biomedical Engineering</h4>
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<p>Chiasson, J.-L., Josse, R. G., Hunt, J. A., Palmason, C., Rodger, N. W., Ross, S. A., ...
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                    <p> Issac Li is a rising fourth-year at the University of Virginia studying Biomedical Engineering from Shijiazhuang, China. Issac is the official Head of Modeling for the 2015 team. Issac is a de facto addition to the BioSquad and also aids in Policy and Practices. </p>
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Wolever*, T. M. S. (1994). The Efficacy of Acarbose in the Treatment of Patients
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                </div>
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with Non–Insulin-Dependent Diabetes Mellitus: A Multicenter, Controlled
+
            </div></a>
−
Clinical Trial. Annals of Internal Medicine, 121(12), 928–935.
+
            <!-- Sean’s popup structural code-->
−
http://doi.org/10.7326/0003-4819-121-12-199412150-00004
+
            <a href="javascript:void(0);"><div class="popup inactive" id="popup-sean">
−
Crude and Age-Adjusted Rate per 100 of Civilian, Noninstitutionalized Population with
+
                <div class="text-wrap">
−
Diagnosed Diabetes, United States, 1980–2011. (2014, September 5). Retrieved
+
                    <p>(click to close)</p>
−
April 24, 2015, from
+
                    <img src="/wiki/images/a/ad/Virginia_sean2.jpg"></img>
−
http://www.cdc.gov/diabetes/statistics/prev/national/figage.htm
+
                    <h3>Sean Sequeira</h3>
−
</p>
+
                    <h5>Modelling Team Member, Policy and Practices Team Member, and Finance Team Member</h5>
−
<p>Dedonder, R. 1966. Levansucrase from Bacillus subtilis. Methods Enzymol. 8:500–505.</p>
+
                    <h4>Class of 2018 - School of Engineering and Applied Sciences, Biomedical Engineering</h4>
−
<p>Deshpande, A. D., Harris-Hayes, M., & Schootman, M. (2008). Epidemiology of diabetes
+
                    <p>Sean Sequeira is a rising second-year studying Biomedical Engineering at the University of Virginia from Glen Allen, VA. He is a valued member of the Financial Team, the Modelling team, and the Policy and Practices team.   Sean can frequently be found working on probiotic research, figuring out sources for funding, or thinking of ways to make the Policy and Practices documentary Oscar worthy.</p>
−
and diabetes-related complications. Physical therapy, 88(11), 1254-1264.
+
                </div>
−
</p>
+
            </div></a>
−
<p>D.M. Nathan, P.A. Cleary, J.Y. Backlund, S.M. Genuth, J.M. Lachin, T.J. Orchard, et al.,
+
            <!-- Shiran’s popup structural code-->
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Intensive diabetes treatment and cardiovascular disease in patients with type 1
+
            <a href="javascript:void(0);"><div class="popup inactive" id="popup-shiran">
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diabetes, N Engl J Med, 353 (2005), pp. 2643–2653
+
                <div class="text-wrap">
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</p>
+
                    <p>(click to close)</p>
−
<p>D.R. Whiting, L. Guariguata, C. Weil, J. Shaw, IDF diabetes atlas: global estimates of the  
+
                    <img src="/wiki/images/0/0f/Virginia_shiran2.jpg"></img>
−
prevalence of diabetes for 2011 and 2030 Diabetes Res Clin Pract, 94 (2011), pp.  
+
                    <h3>Shiran Su</h3>
−
311–321
+
                    <h5>Laboratory Technician and Biological Research Team Member</h5>
−
</p>
+
                    <h4>Class of 2016 - School of Engineering and Applied Sciences, Biomedical Engineering</h4>
−
<p>Duncan, A. E. (2012). Hyperglycemia and Perioperative Glucose Management.Current
+
                    <p>Shiran Su is a rising fourth-year at the University of Virginia from Nanjing, China. Shiran is finishing up her degree in Biomedical Engineering this year. Shiran is a dedicated member of the so-called BioSquad. Without fail, one can either find Shiran somewhere in the building taking a quick daytime nap on a bench or lecturing another engineering teammate about the ease of the U.Va. engineering curriculum, especially after s/he has been complaining about a difficult class.</p>
−
Pharmaceutical Design, 18(38), 6195–6203.
+
                </div>
−
</p>
+
            </div></a>
−
<p>Edelman, P. S., Maier, H., & Wilhelm, K. (2012). Pramlintide in the Treatment of
+
            <!-- Connor’s popup structural code-->
−
Diabetes Mellitus. BioDrugs, 22(6), 375–386. http://doi.org/10.2165/0063030-
+
            <a href="javascript:void(0);"><div class="popup inactive" id="popup-connor">
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200822060-00004
+
                <div class="text-wrap">
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</p>
+
                    <p>(click to close)</p>
−
<p>Ferraris, R. P., Yasharpour, S. A. S. A. N., Lloyd, K. C., Mirzayan, R. A. F. F. Y., &
+
                    <img src="/wiki/images/f/f3/Virginia_connor2.jpg"></img>
−
Diamond, J. M. (1990). Luminal glucose concentrations in the gut under normal
+
                    <h3>Connor Jahelka</h3>
−
conditions. American Journal of Physiology-Gastrointestinal and Liver
+
                    <h5>Head of Policy & Practices</h5>
−
Physiology, 259(5), G822-G837.
+
                    <h4>Class of 2017 - College of Arts and Sciences, Biology </h4>
−
</p>
+
                    <p> Connor Jahelka is a rising third-year at the University of Virginia from Fairfax, Virginia. Connor is studying biology and splits his time between a neuroscience lab and iGEM during the summer. Connor is the Head of Policy and Practices for this year’s team. Connor has a notoriously faulty alarm clock, on which he blames his persistent lateness, and he works most effectively when given very detailed, itemized to-do lists and constant negative reinforcement, mostly provided by Liam.</p>
−
<p>Gay, P., Le Coq, D., Steinmetz, M., Ferrari, E., & Hoch, J. A. (1983). Cloning structural
+
                </div>
−
gene sacB, which codes for exoenzyme levansucrase of Bacillus subtilis:
+
            </div></a>
−
expression of the gene in Escherichia coli. Journal of bacteriology,153(3), 1424-
+
            <!-- END Pop-ups structural code -->
−
1431.
+
            <div class="wrapper1">
−
</p>
+
                <div class="team_profile_link">
−
<p>Gray, G. M., & Ingelfinger, F. J. (1966). Intestinal absorption of sucrose in man:
+
                    <a href="https://igem.org/Team.cgi" >
−
interrelation of hydrolysis and monosaccharide product absorption. Journal of
+
                        <div>
−
Clinical Investigation, 45(3), 388.
+
                            <img src="/wiki/images/1/10/Virginia_igem_logo.jpg"></img>
−
</p>
+
                        </div>
−
<p>Grant, R. W., Buse, J. B., & Meigs, J. B. (2005). Quality of Diabetes Care in U.S.
+
                        <div>
−
Academic Medical Centers Low rates of medical regimen change. Diabetes Care,  
+
                            <p>Official iGEM Team Profile</p>
−
28(2), 337–442. http://doi.org/10.2337/diacare.28.2.337
+
                        </div>
−
</p>
+
                    </a>
−
<p>Grant, R. W., Pirraglia, P. A., Meigs, J. B., & Singer, D. E. (2004). Trends in complexity
+
                </div>
−
of diabetes care in the United States from 1991 to 2000. Archives of Internal
+
                <div class="team_profile_link">
−
Medicine, 164(10), 1134–1139. http://doi.org/10.1001/archinte.164.10.1134
+
                    <a href="http://seas.virginia.edu/students/igem/" >
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</p>
+
                        <div>
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<p>Halschou, K., Bukhave, K., & Rikardt, J. (2012). Intestinal Disaccharidase Activity and
+
                            <img src="/wiki/images/a/a7/Virginia_rotunda.png"></img>
−
Uptake of Glucose from Sucrose. In S. Chackrewarthy (Ed.), Glucose Tolerance.
+
                        </div>
−
InTech. Retrieved from http://www.intechopen.com/books/glucose-
+
                        <div>
−
tolerance/intestinal-disaccharidase-activity-and-uptake-of-glucose-from-sucrose
+
                            <p>Official U.Va. iGEM Website</p>
−
</p>
+
                        </div>
−
<p>Hanahan, D. (1983). Studies on transformation of Escherichia coli with plasmids. Journal
+
                    </a>
−
of Molecular Biology, 166(4), 557–580.
+
                </div>
−
</p>
+
            </div>
−
<p>Hoffmann, J., & Spengler, M. (1997). Efficacy of 24-Week Monotherapy With Acarbose,
+
            <h1>University of Virginia 2015 iGEM Team Members</h1>
−
Metformin, or Placebo in Dietary-Treated NIDDM Patients: The Essen-II Study.
+
            <p id="parenth">(click an image to learn more about any team member)</p>
−
The American Journal of Medicine, 103(6), 483–490.
+
            <!-- BEGIN Team photos structural code -->
−
http://doi.org/10.1016/S0002-9343(97)00252-0
+
            <div id="team-info">
−
Intensive blood-glucose control with sulphonylureas or insulin compared with
+
                <div class="container">
−
conventional treatment and risk of complications in patients with type 2 diabetes
+
                    <!--Supraja Chittari-->
−
(UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.
+
                    <a href="javascript:void(0);"><div class="team-box" id="supraja-box">
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</p>
+
                        <img src="/wiki/images/0/06/Virginia_supraja.jpg">
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<p>Jenkins, D. J. A., Wolever, T. M. S., & Jenkins, A. L. (1988). Starchy Foods and  
+
                            <p>Supraja Chittari</p>
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Glycemic Index. Diabetes Care, 11(2), 149–159.
+
                        </img>
−
http://doi.org/10.2337/diacare.11.2.149
+
                    </div></a>
−
</p>
+
                    <!--Dominic Ritchey-->
−
<p>Jones, M. C. (2007). Therapies for diabetes: pramlintide and exenatide. American Family
+
                    <a href="javascript:void(0);"><div class="team-box" id="dominic-box">
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Physician, 75(12), 1831–1835.
+
                        <img src="/wiki/images/a/af/Virginia_dominic.jpg">
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</p>
+
                            <p>Dominic Ritchey</p>
−
<p>J Reizer, S. L. S. (1992). Functional interactions between proteins of the  
+
                        </img>
−
phosphoenolpyruvate:sugar phosphotransferase systems of Bacillus subtilis and
+
                    </div></a>
−
Escherichia coli. The Journal of Biological Chemistry, 267(13), 9158–69.
+
                    <!-- Jingyuan Zhang -->
−
Jenkins, D. J., Wolever, T. M., & Jenkins, A. L. (1988). Starchy foods and glycemic
+
                    <a href="javascript:void(0);"><div class="team-box" id="jingyuan-box">
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index. Diabetes care, 11(2), 149-159.
+
                        <img src="/wiki/images/3/37/Virginia_jingyuan.jpg">
−
</p>
+
                            <p>Jingyuan Zhang</p>
−
<p>Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Cotran, Ramzi S. ; Robbins, Stanley L.
+
                        </img>
−
(2005). Robbins and Cotran Pathologic Basis of Disease (7th ed.). Philadelphia,
+
                    </div></a>
−
Pa.: Saunders. pp. 1194–1195. ISBN 0-7216-0187-1. Lancet. 1998 Sep 12;
+
                    <!-- Liam Wolf -->
−
352(9131):837-53.
+
                    <a href="javascript:void(0);"><div class="team-box" id="liam-box">
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</p>
+
                        <img src="/wiki/images/e/ef/Virginia_liam.jpg">
−
<p>Kundig, W., Ghosh, S., & Roseman, S. (1964). PHOSPHATE BOUND TO HISTIDINE
+
                            <p>Liam Wolf</p>
−
IN A PROTEIN AS AN INTERMEDIATE IN A NOVEL PHOSPHO-
+
                        </img>
−
TRANSFERASE SYSTEM. Proceedings of the National Academy of Sciences of
+
                    </div></a>
−
the United States of America, 52, 1067–1074.
+
                    <!-- Rena Yuan -->
−
</p>
+
                    <a href="javascript:void(0);"><div class="team-box" id="rena-box">
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<p>Lebovitz, H. E. (1997). ALPHA-GLUCOSIDASE INHIBITORS. Endocrinology and
+
                        <img src="/wiki/images/b/bd/Virginia_rena.jpg">
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Metabolism Clinics of North America, 26(3), 539–551.
+
                            <p>Rena Yuan</p>
−
http://doi.org/10.1016/S0889-8529(05)70266-8
+
                        </img>
−
</p>
+
                    </div></a>
−
<p>Lourens-Hattingh, A., & Viljoen, B. C. (2001). Yogurt as probiotic carrier food.
+
                    <!-- Issac Li -->
−
International Dairy Journal, 11(1–2), 1–17. http://doi.org/10.1016/S0958-
+
                    <a href="javascript:void(0);"><div class="team-box" id="issac-box">
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6946(01)00036-X
+
                        <img src="/wiki/images/3/3b/Virginia_issac.jpg">
−
</p>
+
                            <p>Issac Li</p>
−
<p>Malagelada, J. R., Bazzoli, F., Elewaut, A., Fried, M., Krabshuis, J. H., Lindberg, G., ...
+
                        </img>
−
Vakil, N. (2007). World Gastroenterology Organisation Practice Guidelines.
+
                    </div></a>
−
Dysphagia. Retrieved from http://almacen-
+
                    <!-- Sean Sequeira -->
−
gpc.dynalias.org/publico/Dysphagia%20WGO%202004%20Ingles.pdf
+
                    <a href="javascript:void(0);"><div class="team-box" id="sean-box">
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</p>
+
                        <img src="/wiki/images/8/8e/Virginia_sean.jpg">
−
<p>Man, C. D., Camilleri, M., & Cobelli, C. (2006). A System Model of Oral Glucose
+
                            <p>Sean Sequeira</p>
−
Absorption: Validation on Gold Standard Data. IEEE Transactions on Biomedical  
+
                        </img>
−
Engineering, 53(12), 2472–2478. http://doi.org/10.1109/TBME.2006.883792
+
                    </div></a>
−
</p>
+
                    <!-- Shiran Su -->
−
<p>Meigs, J. B., Nathan, D. M., Wilson, P. W., Cupples, L. A., & Singer, D. E. (1998).
+
                    <a href="javascript:void(0);"><div class="team-box" id="shiran-box">
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Metabolic risk factors worsen continuously across the spectrum of nondiabetic
+
                        <img src="/wiki/images/8/8b/Virginia_shiran.jpg">
−
glucose tolerance. The Framingham Offspring Study. Annals of Internal Medicine,  
+
                            <p>Shiran Su</p>
−
128(7), 524–533.
+
                        </img>
−
</p>
+
                    </div></a>
−
<p>Narimasa, S., Tatsuo, H., Mitsutaka, Y., & Toshio, I. (1979). Action of human pancreatic
+
                    <!-- Connor Jahelka -->
−
and salivary α-amylases on maltooligosaccharides: Evaluation of kinetic
+
                    <a href="javascript:void(0);"><div class="team-box" id="connor-box">
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parameters. Clinica Chimica Acta, 97(2–3), 253–260.
+
                        <img src="/wiki/images/0/03/Virginia_connor.jpg">
−
http://doi.org/10.1016/0009-8981(79)90423-6
+
                            <p>Connor Jahelka</p>
−
</p>
+
                        </img>
−
<p>National Diabetes Data Group. (1979). Classification and Diagnosis of Diabetes Mellitus
+
                    </div></a>
−
and Other Categories of Glucose Intolerance. Diabetes, 28(12), 1039–1057.
+
                </div>
−
http://doi.org/10.2337/diab.28.12.1039
+
            </div>
−
</p>
+
            <!-- SPECIFIC STRUCTURAL CODE ENDS HERE -->
−
<p>Nissle, A. (1959). [Explanations of the significance of colonic dysbacteria & the
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            <footer>
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mechanism of action of E. coli therapy (mutaflor)]. Die Medizinische, 4(21),
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1017–1022.
+
                    <img src="https://static.igem.org/mediawiki/2015/d/d1/Virginia_logo4.png"></img>
−
</p>
+
                </div>
−
<p>Parkin, C. G., & Brooks, N. (2002). Is postprandial glucose control important? Is it
+
                <div id="foot-text">
−
practical in primary care settings?. Clinical Diabetes, 20(2), 71-76.
+
                    <p>University of Virginia iGEM</p>
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</p>
+
                    <p>148 Gilmer Hall</p>
−
<p>Patterson, Joan (2013). Many Schools Cutting Back on Physical Education. Las Vegas
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                    <p>485 McCormick Road</p>
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                    <p>Charlottesville, Virginia 22904</p>
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+
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                    <p>
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<p>Recorbet, G. H. I. S. L. A. I. N. E., Robert, C., Givaudan, A., Kudla, B., Normand, P., &
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soil that uses the Bacillus subtilis sacB gene. Applied and environmental
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+
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unmarked mutations in Gram-negative bacteria by marker exchange-eviction
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</p>
+
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<p>Riddle, M., Frias, J., Zhang, B., Maier, H., Brown, C., Lutz, K., & Kolterman, O. (2007).
+
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Pramlintide Improved Glycemic Control and Reduced Weight in Patients With
+
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Type 2 Diabetes Using Basal Insulin. Diabetes Care, 30(11), 2794–2799.
+
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+
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</p>
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<p>Saydah, S. H., Miret, M., Sung, J., Varas, C., Gause, D., & Brancati, F. L. (2001).
+
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Postchallenge Hyperglycemia and Mortality in a National Sample of U.S. Adults.
+
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Diabetes Care, 24(8), 1397–1402. http://doi.org/10.2337/diacare.24.8.1397
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</p>
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<p>Snelling, Anatasia; Korba, Casey; Burkey, Alyvia (2007). The National School Lunch
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and Competitive Food Offerings and Purchasing Behaviors of High School
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<p>S.M. Haffner, S. Lehto, T. Ronnemaa, K. Pyorala, M. Laakso, Mortality from coronary
+
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−
</p>
+
−
<p>Diabetes Care, 23(12), 1830–1834. http://doi.org/10.2337/diacare.23.12.1830
+
−
What are normal blood glucose levels? Retrieved from Virginia Mason Medical Center
+
−
website: https://www.virginiamason.org/whatarenormalbloodglucoselevels.
+
−
Accessed: May. 5th ,2015
+
−
</p>
+
−
</div>
+
−
</div>
+
−
</div>
+
−
<script type="text/javascript">
+
−
jQuery(document).ready(function(){
+
−
$("#ref-button").click(function(){
+
−
$("#ref-button").fadeOut("fast");
+
−
$("#ref-content").fadeIn("fast");
+
−
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+
−
});
+
−
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+
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+
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+
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+
−
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+
−
});
+
−
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+
−
<div class="learn-more">
+
−
<div class="container">
+
−
<div class="box" id="b1">
+
−
<a href="/Team:Virginia/Team">
+
−
<p>TEAM</p>
+
−
<img src="/wiki/images/d/d1/Virginia_logo4.png"></img>
+
−
</a>
+
−
</div>
+
−
<div class="box" id="b2">
+
−
<a href="/Team:Virginia/Project">
+
−
<p>PROJECT</p>
+
−
<img src="/wiki/images/d/d1/Virginia_logo4.png"></img>
+
−
</a>
+
−
</div>
+
−
<div class="box" id="b3">
+
−
<a href="/Team:Virginia/Practices">
+
−
<p>POLICY AND PRACTICES</p>
+
−
<img src="/wiki/images/d/d1/Virginia_logo4.png"></img>
+
−
</a>
+
−
</div>
+
−
<div class="box" id="b4">
+
−
<a href="/Team:Virginia/Attributions">
+
−
<p>ATTRIBUTIONS</p>
+
−
<img src="/wiki/images/d/d1/Virginia_logo4.png"></img>
+
−
</a>
+
−
</div>
+
−
<div class="box" id="b5">
+
−
<a href="/Team:Virginia/Attributions">
+
−
<p>CONTACT US</p>
+
−
<img src="/wiki/images/d/d1/Virginia_logo4.png"></img>
+
−
</a>
+
−
</div>
+
−
<div class="box" id="b6">
+
−
<a href="#">
+
−
<p>ABOUT</p>
+
−
</a>
+
−
</div>
+
−
</div>
+
−
</div>
+
−
</div>
+
−
</div>
+
−
<footer>
+
−
<div id="foot-img">
+
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<img src="https://static.igem.org/mediawiki/2015/d/d1/Virginia_logo4.png"></img>
+
−
</div>
+
−
<div id="foot-text">
+
−
<p>University of Virginia iGEM</p>
+
−
<p>148 Gilmer Hall</p>
+
−
<p>485 McCormick Road</p>
+
−
<p>Charlottesville, Virginia 22904</p>
+
−
<p>United States of America</p>
+
−
<p></p>
+
−
<p><a href="mailto:virginia.igem@gmail.com">
+
 
virginia.igem@gmail.com</a>
 
virginia.igem@gmail.com</a>
−
</p>
+
                    </p>
−
</div>
+
                </div>
−
</footer>
+
            </footer>
−
</div>
+
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−
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+
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+
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+
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+
−
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+
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+
−
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+
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+
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+
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+
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+
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+
−
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+
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+
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+
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+
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+
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+
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+
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+
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+
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+
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+
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+
 
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 +
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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−
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+
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−
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−
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−
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+
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+
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−
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+
 
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−
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+
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−
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+
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−
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+
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 +
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 +
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−
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+
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+
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+
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−
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+
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+
 
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+
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−
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+
 
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+
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−
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+
 
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−
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+
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−
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+
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−
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+
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−
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+
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−
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+
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 +
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+
.team_profile_link{
−
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+
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 +
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 +
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 +
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−
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+
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+
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+
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+
 
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−
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+
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−
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+
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−
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+
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+
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−
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+
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+
 
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−
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+
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−
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+
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+
 
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−
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+
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−
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+
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 +
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−
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+
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−
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+
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−
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+
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+
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+
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+
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+
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+
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+
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+
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+
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+
 
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−
<script type="text/javascript">
+
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−
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+
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+
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+
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+
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+
−
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+
−
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+

Latest revision as of 20:33, 18 September 2015

University of Virginia iGEM 2015

Official iGEM Team Profile

Official U.Va. iGEM Website

University of Virginia 2015 iGEM Team Members

(click an image to learn more about any team member)

University of Virginia iGEM

148 Gilmer Hall

485 McCormick Road

Charlottesville, Virginia 22904

United States of America

virginia.igem@gmail.com