Template:Heidelberg/pages/results

	Team is successfully registered!
	Judging form is completed and submitted!
	Project is showcased on the iGEM wiki!
	Proper list attributions!
	Part:BBa_K1614002 is documented and submitted!

	Part:BBa_K1614016 successfully validated and documented!
	Part:BBa_K1614016 submitted to the registry!
	Spread knowledge about synthetic biology in the city of Heidelberg!

	Held a panel discussion which was lifestreamed and simultaniously translated into English!
	Cooperated with iGEM Michigan. We calculated aptamers for their setup using our MAWS software
	Improved Part:BBa_K1614019 by making it switchable via ATP!
	Demonstrated a functional prototype!
	Developed a software in close contact with the wetlab work!
	Optimised our software until it can be run fully functional in the timeframe the demo suite offers!

AptaBodies

• Fast and cheap

• MAWS can generate specific AptaBodies against each and every protein of interest

• Easy to design for proteins for which no antibodies are available yet

Real-time Small molecule sensing

Validation of our JAWS Software

Sensing of ATP concentrations in biochemical reactions

Real time monitoring of in vitro transcriptions

Cystic fibrosis

Functional proof of cleavage activity in vivo

De novo construction of a new active site in twin ribozymes

Proposeal of Ribozyme as therapeutic agent in Cystic fibrosis

Labelling and vizualization

A novel strategy using mimicking HRP DNAzyme can be used for labeling of sDNA and RNA

Modeling and Software validation

Fully automatable high-throughput workflow to screen aptamer and allosteric DNAzyme candidates

Our system is able to design aptamer candidates and give estimates for the affinity and switching behavior

The aptamers created by our software were experimentally proven to work

Establishment of a cleavage activated HRP-mimicking DNAzyme that can be applied in real life screening assays

Standardization

A novel Standard (RFC 110) is useful for cloning and expression of functional RNA.