Difference between revisions of "Team:SDU-Denmark/Tour21"
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Antibodies are produced by B-lymphocytes of the adaptive immune system. They are highly specific proteins that remain surface-bound on the B-lymphocyte until it recognizes a foreign molecule like bacterial or viral proteins, generally termed an antigen. An antibody will recognize through binding a specific region of the antigen, called an epitope (1). Once the surface-bound antibody encounters an antigen to which it can bind, the B-lymphocyte will become activated. The activated B-lymphocyte will start to grow and proliferate, producing clones of itself. It can further differentiate into three types of cells, including the plasma cell, from which the antibodies will be secreted (2). The antibody will be changed from a surface-bound receptor molecule to a soluble and secreted molecule by an alternative splicing mechanism of the pre-mRNA transcript of the antibody | Antibodies are produced by B-lymphocytes of the adaptive immune system. They are highly specific proteins that remain surface-bound on the B-lymphocyte until it recognizes a foreign molecule like bacterial or viral proteins, generally termed an antigen. An antibody will recognize through binding a specific region of the antigen, called an epitope (1). Once the surface-bound antibody encounters an antigen to which it can bind, the B-lymphocyte will become activated. The activated B-lymphocyte will start to grow and proliferate, producing clones of itself. It can further differentiate into three types of cells, including the plasma cell, from which the antibodies will be secreted (2). The antibody will be changed from a surface-bound receptor molecule to a soluble and secreted molecule by an alternative splicing mechanism of the pre-mRNA transcript of the antibody | ||
<span class="sourceReference">gene</span> | <span class="sourceReference">gene</span> | ||
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<span class="tooltipHeader> Reference: </span> | <span class="tooltipHeader> Reference: </span> | ||
Lubert Stryer JMB, John L. Tymoczko. The Immune System. Biochemistry. 7 ed: W. H. Freeman and Company; 2012. | Lubert Stryer JMB, John L. Tymoczko. The Immune System. Biochemistry. 7 ed: W. H. Freeman and Company; 2012. | ||
</span>. | </span>. | ||
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Revision as of 11:03, 26 August 2015
Antibody production
Introduction
Nowadays industrial production methods of antibodies involves the use of laboratory animals by exploding their immune systems ability to generate antibodies. Antibodies have a diverse set of applications and the ability to produce antibodies to fit a specific need is essential. Of the current techniques, the hybridoma technology is the most widely used method for producing monoclonal antibodies (mAb).
