Difference between revisions of "Team:technion"
Line 11: | Line 11: | ||
position: fixed; | position: fixed; | ||
z-index: 999; | z-index: 999; | ||
− | |||
left: 0; | left: 0; | ||
top: 20px; | top: 20px; | ||
Line 307: | Line 306: | ||
<script type="text/javascript" src="https://2015.igem.org/Template:Technion/Javascript? | <script type="text/javascript" src="https://2015.igem.org/Template:Technion/Javascript? | ||
action=raw&ctype=text/javascript"></script> | action=raw&ctype=text/javascript"></script> | ||
+ | |||
+ | <!-----------------------------------------------nav-bar-script----------------------------------------> | ||
+ | <script type="text/javascript"> | ||
+ | $(document).ready(function() { | ||
+ | /************************reset parameters*********************************/ | ||
+ | var p = $("#project").offset(); | ||
+ | $("#project_Links").css({"padding-left": (p.left-0)}); | ||
+ | |||
+ | p = $("#Lab_Notebook").offset(); | ||
+ | $("#Lab_Notebook_Links").css({"padding-left": (p.left-0)}); | ||
+ | |||
+ | p = $("#Human_Practices").offset(); | ||
+ | $("#Human_Practices_Links").css({"padding-left": (p.left-0)}); | ||
+ | |||
+ | p = $("#Judging_Criteria").offset(); | ||
+ | $("#Judging_Criteria_Links").css({"padding-left": (p.left-0)}); | ||
+ | |||
+ | p = $("#Team").offset(); | ||
+ | $("#Team_Links").css({"padding-left": (p.left-0)}); | ||
+ | /************************reset parameters-end*****************************/ | ||
+ | |||
+ | /************************reset parameters on resize***********************/ | ||
+ | $(window).resize(function() { | ||
+ | var p = $("#project").offset(); | ||
+ | $("#project_Links").css({"padding-left": (p.left-0)}); | ||
+ | |||
+ | p = $("#Lab_Notebook").offset(); | ||
+ | $("#Lab_Notebook_Links").css({"padding-left": (p.left-0)}); | ||
+ | |||
+ | p = $("#Human_Practices").offset(); | ||
+ | $("#Human_Practices_Links").css({"padding-left": (p.left-0)}); | ||
+ | |||
+ | p = $("#Judging_Criteria").offset(); | ||
+ | $("#Judging_Criteria_Links").css({"padding-left": (p.left-0)}); | ||
+ | |||
+ | p = $("#Team").offset(); | ||
+ | $("#Team_Links").css({"padding-left": (p.left-0)}); | ||
+ | }); | ||
+ | /************************reset parameters on resize-end*******************/ | ||
+ | |||
+ | /************************on hover events for main buttons*****************/ | ||
+ | $("#project, #project_Links").hover(function() { | ||
+ | $("#project_Links").css({"max-height": "50px"}); | ||
+ | }, | ||
+ | function() { | ||
+ | $("#project_Links").css({"max-height": "0px"}); | ||
+ | }); | ||
+ | |||
+ | $("#Lab_Notebook, #Lab_Notebook_Links").hover(function() { | ||
+ | $("#Lab_Notebook_Links").css({"max-height": "50px"}); | ||
+ | }, | ||
+ | function() { | ||
+ | $("#Lab_Notebook_Links").css({"max-height": "0px"}); | ||
+ | }); | ||
+ | |||
+ | $("#Human_Practices, #Human_Practices_Links").hover(function() { | ||
+ | $("#Human_Practices_Links").css({"max-height": "50px"}); | ||
+ | }, | ||
+ | function() { | ||
+ | $("#Human_Practices_Links").css({"max-height": "0px"}); | ||
+ | }); | ||
+ | |||
+ | $("#Judging_Criteria, #Judging_Criteria_Links").hover(function() { | ||
+ | $("#Judging_Criteria_Links").css({"max-height": "50px"}); | ||
+ | }, | ||
+ | function() { | ||
+ | $("#Judging_Criteria_Links").css({"max-height": "0px"}); | ||
+ | }); | ||
+ | |||
+ | $("#Team, #Team_Links").hover(function() { | ||
+ | $("#Team_Links").css({"max-height": "50px"}); | ||
+ | }, | ||
+ | function() { | ||
+ | $("#Team_Links").css({"max-height": "0px"}); | ||
+ | }); | ||
+ | /************************on hover events for main buttons-end*************/ | ||
+ | |||
+ | }); | ||
+ | </script> | ||
+ | <!-----------------------------------------------nav-bar-script-end------------------------------------> | ||
</body> | </body> | ||
</html> | </html> |
Revision as of 17:53, 10 September 2015
page title
Hair loss affects roughly 61 million people in the United States. More than 95% of hair thinning in men is attributed to male pattern baldness, or androgenetic alopecia. The hair loss product market is a multi-billion dollar market: in the United States alone, this market’s annual revenue is 7 billion dollars, with 3.5% annual growth rate from 2007 to 2012, yet a sufficient solution has yet to be made available. The trigger for androgenetic alopecia is believed to be dihydrotestosterone (DHT), a derivative of testosterone. This summer, we are engineering Bacillus Subtilis, a model organism for a bacterium found naturally on the scalp, to secrete 3α-hydroxysteroid dehydrogenase (3-α-HSD). This enzyme reduces DHT to a non-steroidically active compound, using NADPH and NADH as cofactors.
Our project consists of 3 main parts: 3-α-HSD secretion by the bacterium, engineered bacterium for NADPH overproduction, and a comb as a tool to create a user-friendly experience. By synchronizing these parts, we hope to be able to show convincing evidence of DHT breakdown, providing a promising platform for treatment of male pattern baldness!