Difference between revisions of "Team:technion"

 
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<title>Team: Technion 2015</title>
 
<title>Team: Technion 2015</title>
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<body>
 
<body>
  
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<header>
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<!--<header>
 
 
 
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<span class="btn-bg3"></span>
 
<span class="btn-bg3"></span>
 
<div class="sub3">
 
<div class="sub3">
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<a href="#">sublink1</a>
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<a href="https://2015.igem.org/Team:Technion_Israel/Parts">Parts</a>
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<a href="#">sublink2</a>
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<a href="https://2015.igem.org/Team:Technion_Israel/Judging_Criteria/Achievements">Achievements</a>
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<a href="#">sublink3</a>
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<a href="https://2015.igem.org/Team:Technion_Israel/Collaborations">Collaborations</a>
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<a href="https://2015.igem.org/Team:Technion_Israel/Design">Design</a>
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<a href="https://2015.igem.org/Team:Technion_Israel/Entrepreneurship">Entrepreneurship</a>
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<span class="btn-bg4"></span>
 
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<a href="https://2015.igem.org/Team:Technion_Israel/Practices/Education">Education</a>
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<a href="https://2015.igem.org/Team:Technion_Israel/Team/About_Us">About&nbsp;Us</a>
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<a href="https://2015.igem.org/Team:Technion_Israel/Project/NADPH">NADPH</a>
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<a href="https://2015.igem.org/Team:Technion_Israel/Project/Comb">Comb</a>
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Latest revision as of 19:04, 10 September 2015

Team: Technion 2015

Project
Lab Notebook
Human Practices
Judging Criteria
Team

page title

Our team is developing a treatment for male pattern baldness.

Hair loss affects roughly 61 million people in the United States. More than 95% of hair thinning in men is attributed to male pattern baldness, or androgenetic alopecia. The hair loss product market is a multi-billion dollar market: in the United States alone, this market’s annual revenue is 7 billion dollars, with 3.5% annual growth rate from 2007 to 2012, yet a sufficient solution has yet to be made available. The trigger for androgenetic alopecia is believed to be dihydrotestosterone (DHT), a derivative of testosterone. This summer, we are engineering Bacillus Subtilis, a model organism for a bacterium found naturally on the scalp, to secrete 3α-hydroxysteroid dehydrogenase (3-α-HSD). This enzyme reduces DHT to a non-steroidically active compound, using NADPH and NADH as cofactors.

Our project consists of 3 main parts: 3-α-HSD secretion by the bacterium, engineered bacterium for NADPH overproduction, and a comb as a tool to create a user-friendly experience. By synchronizing these parts, we hope to be able to show convincing evidence of DHT breakdown, providing a promising platform for treatment of male pattern baldness!

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