Difference between revisions of "Team:technion"
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+ | {{Template_All_Teams}} | ||
<html> | <html> | ||
− | < | + | <head> |
− | <img src="https://static.igem.org/mediawiki/2015/a/ | + | <meta charset="utf-8"/> |
− | <a | + | |
− | </main> | + | <link rel="stylesheet" type="text/css" href="https://2015.igem.org/Template:Technion/CSS?action=raw&ctype=text/css" /> |
+ | |||
+ | <!-------------------------------------------nav-style----------------------------------------------------------------------> | ||
+ | <style type="text/css"> | ||
+ | .nav_menu { | ||
+ | position: fixed; | ||
+ | z-index: 999; | ||
+ | left: 0; | ||
+ | top: 18px; | ||
+ | width: 100%; | ||
+ | margin: auto; | ||
+ | font-family: MV Boli; | ||
+ | font-size: 1.6em; | ||
+ | background: rgba(0,0,0,0.8); | ||
+ | height: 44px; | ||
+ | } | ||
+ | |||
+ | .nav_menu nav { | ||
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+ | |||
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+ | |||
+ | #Judging_Criteria_Links, #Judging_Criteria { | ||
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+ | |||
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+ | |||
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+ | #Team_Links a:hover { | ||
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+ | } | ||
+ | |||
+ | .content { | ||
+ | margin-top: 100px; | ||
+ | } | ||
+ | </style> | ||
+ | <!-------------------------------------------nav-style-end------------------------------------------------------------------> | ||
+ | |||
+ | <title>Team: Technion 2015</title> | ||
+ | </head> | ||
+ | <body> | ||
+ | |||
+ | <!--<header> | ||
+ | |||
+ | <img src="https://static.igem.org/mediawiki/2015/f/fc/Team_Technion_Logo.png" alt="Team Logo" id="team_logo" /> | ||
+ | |||
+ | <div class="main_menu"> | ||
+ | <nav> | ||
+ | <a href="#"> | ||
+ | <button class="button_main1"> | ||
+ | <span class="btn-text">Project</span> | ||
+ | <span class="btn-bg"></span> | ||
+ | </button> | ||
+ | </a> | ||
+ | <a href="#"> | ||
+ | <button class="button_main2"> | ||
+ | <span class="btn-text">Lab Notebook</span> | ||
+ | <span class="btn-bg"></span> | ||
+ | </button> | ||
+ | </a> | ||
+ | <a href="#"> | ||
+ | <button class="button_main3"> | ||
+ | <span class="btn-text">Judging Criteria</span> | ||
+ | <span class="btn-bg"></span> | ||
+ | </button> | ||
+ | </a> | ||
+ | <a href="#"> | ||
+ | <button class="button_main4"> | ||
+ | <span class="btn-text">Human Practices</span> | ||
+ | <span class="btn-bg"></span> | ||
+ | </button> | ||
+ | </a> | ||
+ | <a href="#"> | ||
+ | <button class="button_main5"> | ||
+ | <span class="btn-text">Team</span> | ||
+ | <span class="btn-bg"></span> | ||
+ | </button> | ||
+ | </a> | ||
+ | </nav> | ||
+ | </div> | ||
+ | </header>--> | ||
+ | |||
+ | <!---------------------------------------dropdown menu----------------------------------- | ||
+ | <div class="dropdown"> | ||
+ | <a href="#"> | ||
+ | <img src="https://static.igem.org/mediawiki/2015/c/c1/Team_Technion_Navbar_Home.png" alt="Home" id="home_nav" /> | ||
+ | <div id="home_text">Navigate</div> | ||
+ | </a> | ||
+ | <nav> | ||
+ | <div class="main1"> | ||
+ | <a href="#">Project</a> | ||
+ | <span class="btn-bg1"></span> | ||
+ | <div class="sub1"> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/Overview">Overview</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/Bacillus">Bacillus</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/E_Coli">E.Coli</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/NADPH">NADPH</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/Comb">Comb</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Modeling">Modeling</a> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div class="main2"> | ||
+ | <a href="#">Lab Notebook</a> | ||
+ | <span class="btn-bg2"></span> | ||
+ | <div class="sub2"> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Lab_Notebook/Overview">Overview</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Lab_Notebook/Protocols">Protocols</a> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div class="main3"> | ||
+ | <a href="#">Judging Criteria</a> | ||
+ | <span class="btn-bg3"></span> | ||
+ | <div class="sub3"> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Parts">Parts</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Judging_Criteria/Achievements">Achievements</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Collaborations">Collaborations</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Design">Design</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Entrepreneurship">Entrepreneurship</a> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div class="main4"> | ||
+ | <a href="#">Human Practices</a> | ||
+ | <span class="btn-bg4"></span> | ||
+ | <div class="sub4"> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Practices/Education">Education</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Practices/Publications">Publications</a> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div class="main5"> | ||
+ | <a href="#">Team</a> | ||
+ | <span class="btn-bg5"></span> | ||
+ | <div class="sub5"> | ||
+ | <a href="#">sublink1</a> | ||
+ | <a href="#">sublink2</a> | ||
+ | <a href="#">sublink3</a> | ||
+ | <a href="#">sublink4</a> | ||
+ | <a href="#">sublink5</a> | ||
+ | <a href="#">sublink6</a> | ||
+ | </div> | ||
+ | </div> | ||
+ | </nav> | ||
+ | </div> | ||
+ | ---------------------------------------dropdown menu-end-----------------------------------> | ||
+ | |||
+ | |||
+ | |||
+ | <!-------------------------------------nav-bar----------------------------------------------> | ||
+ | <div class="nav_menu"> | ||
+ | <div class="main_buttons"> | ||
+ | <div id="project" class="main_button">Project</div> | ||
+ | <div id="Lab_Notebook" class="main_button">Lab Notebook</div> | ||
+ | <div id="Human_Practices" class="main_button">Human Practices</div> | ||
+ | <div id="Judging_Criteria" class="main_button">Judging Criteria</div> | ||
+ | <div id="Team" class="main_button">Team</div> | ||
+ | </div> | ||
+ | <nav> | ||
+ | <div id="Team_Links" class="main_links"> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Team/About_Us">About Us</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Attributions">Attributions</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Team/Sponsors">Sponsors</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Team/gallery">Gallery</a> | ||
+ | </div> | ||
+ | <div id="Judging_Criteria_Links" class="main_links"> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Parts">Parts</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Judging_Criteria/Achievements">Achievements</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Collaborations">Collaborations</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Design">Design</a> | ||
+ | </div> | ||
+ | <div id="Human_Practices_Links" class="main_links"> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Practices">Practices</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Practices/safety">Safety</a> | ||
+ | </div> | ||
+ | <div id="Lab_Notebook_Links" class="main_links"> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Lab_Notebook/Overview">Overview</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Lab_Notebook/Protocols">Protocols</a> | ||
+ | </div> | ||
+ | <div id="project_Links" class="main_links"> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/Overview">Overview</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/Bacillus">Bacillus</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/E_Coli">E.Coli</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/NADPH">NADPH</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Project/Comb">Comb</a> | ||
+ | <a href="https://2015.igem.org/Team:Technion_Israel/Modeling">Modeling</a> | ||
+ | </div> | ||
+ | </nav> | ||
+ | </div> | ||
+ | <!-------------------------------------nav-bar-end------------------------------------------> | ||
+ | |||
+ | <div class="content"> | ||
+ | <h1 class="abstract_title">page title</h1> | ||
+ | <div class="abstract"> | ||
+ | <b>Our team is developing a treatment for male pattern baldness.</b> | ||
+ | <p> | ||
+ | Hair loss affects roughly 61 million people in the United States. More than 95% of hair thinning in men is attributed to male pattern baldness, or androgenetic alopecia. The hair loss product market is a multi-billion dollar market: in the United States alone, this market’s annual revenue is 7 billion dollars, with 3.5% annual growth rate from 2007 to 2012, yet a sufficient solution has yet to be made available. | ||
+ | The trigger for androgenetic alopecia is believed to be dihydrotestosterone (DHT), a derivative of testosterone. | ||
+ | This summer, we are engineering Bacillus Subtilis, a model organism for a bacterium found naturally on the scalp, to secrete 3α-hydroxysteroid dehydrogenase (3-α-HSD). This enzyme reduces DHT to a non-steroidically active compound, using NADPH and NADH as cofactors. | ||
+ | </p> | ||
+ | <p> | ||
+ | Our project consists of 3 main parts: 3-α-HSD secretion by the bacterium, engineered bacterium for NADPH overproduction, and a comb as a tool to create a user-friendly experience. | ||
+ | By synchronizing these parts, we hope to be able to show convincing evidence of DHT breakdown, providing a promising platform for treatment of male pattern baldness! | ||
+ | </p> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | <footer> | ||
+ | <div class="team_name"> | ||
+ | <h3>Contact Us</h3> | ||
+ | </div> | ||
+ | <nav class="connect_links"> | ||
+ | <div class="facebook_link"> | ||
+ | <a href="https://www.facebook.com/technioniGEM2015?pnref=story" target="_blank"> | ||
+ | <img src="https://static.igem.org/mediawiki/2015/0/06/Team_Technion_Footer_facebook.png" alt="Follow us on facebook" /></a> | ||
+ | </div> | ||
+ | <div class="email_link"> | ||
+ | <a href="mailto:igem.technion2015@gmail.com"> | ||
+ | <img src="https://static.igem.org/mediawiki/2015/d/da/Team_Technion_Footer_gmail.png" alt="Send us an Email" /></a> | ||
+ | </div> | ||
+ | </nav> | ||
+ | </footer> | ||
+ | |||
+ | <script type="text/javascript" src="jquery-1.8.0.min.js"></script> | ||
+ | <script type="text/javascript" src="https://2015.igem.org/Template:Technion/Javascript? | ||
+ | action=raw&ctype=text/javascript"></script> | ||
+ | |||
+ | <!-----------------------------------------------nav-bar-script----------------------------------------> | ||
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</html> | </html> |
Latest revision as of 19:04, 10 September 2015
page title
Hair loss affects roughly 61 million people in the United States. More than 95% of hair thinning in men is attributed to male pattern baldness, or androgenetic alopecia. The hair loss product market is a multi-billion dollar market: in the United States alone, this market’s annual revenue is 7 billion dollars, with 3.5% annual growth rate from 2007 to 2012, yet a sufficient solution has yet to be made available. The trigger for androgenetic alopecia is believed to be dihydrotestosterone (DHT), a derivative of testosterone. This summer, we are engineering Bacillus Subtilis, a model organism for a bacterium found naturally on the scalp, to secrete 3α-hydroxysteroid dehydrogenase (3-α-HSD). This enzyme reduces DHT to a non-steroidically active compound, using NADPH and NADH as cofactors.
Our project consists of 3 main parts: 3-α-HSD secretion by the bacterium, engineered bacterium for NADPH overproduction, and a comb as a tool to create a user-friendly experience. By synchronizing these parts, we hope to be able to show convincing evidence of DHT breakdown, providing a promising platform for treatment of male pattern baldness!