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| <h2>How to control the population of S.mutans</h2> | | <h2>How to control the population of S.mutans</h2> |
| <span style="margin-bottom:10%">Antimicrobial peptides are recently regarded as a promising choice to kill microbes due to their strong microbicidal effects and their unlikeliness of triggering resistance in microorganisms. Since there are also various kinds of probiotics living in our mouth besides oral pathogens, and since antimicrobial peptides have effect on general kinds of microorganisms, it’s more wise to modify the antimicrobial peptide into a targeted one by adding a S.mutans targeted sequence on the N-terminal, so that only S.mutans can be killed. Thus we design two fused peptides, CAP-glyglygly-Bac8c and CAP-glyglygly-APP2, to targetedly inhibit the growth of S.mutans in oral cavity, where CAP is an optimized peptide that can specifically bind to the comD receptor on the surface of S.mutans, while Bac8c and APP2 are two kinds of peptides that assume strong bactericidal effect in acidic environment. | | <span style="margin-bottom:10%">Antimicrobial peptides are recently regarded as a promising choice to kill microbes due to their strong microbicidal effects and their unlikeliness of triggering resistance in microorganisms. Since there are also various kinds of probiotics living in our mouth besides oral pathogens, and since antimicrobial peptides have effect on general kinds of microorganisms, it’s more wise to modify the antimicrobial peptide into a targeted one by adding a S.mutans targeted sequence on the N-terminal, so that only S.mutans can be killed. Thus we design two fused peptides, CAP-glyglygly-Bac8c and CAP-glyglygly-APP2, to targetedly inhibit the growth of S.mutans in oral cavity, where CAP is an optimized peptide that can specifically bind to the comD receptor on the surface of S.mutans, while Bac8c and APP2 are two kinds of peptides that assume strong bactericidal effect in acidic environment. |
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| <img src="https://static.igem.org/mediawiki/2015/6/63/WHU-China_KJT.png" width="400"></img> | | <img src="https://static.igem.org/mediawiki/2015/6/63/WHU-China_KJT.png" width="400"></img> |
− | <img src="https://static.igem.org/mediawiki/2015/0/08/WHU-China_KJT2.png" width="400"></img></span> | + | <img src="https://static.igem.org/mediawiki/2015/0/08/WHU-China_KJT2.png" width="400" style="margin-top:10%"></img></span> |
| </div></div> | | </div></div> |
| <div class="editarea" id="member2"> | | <div class="editarea" id="member2"> |