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| − | + | Such diagnoses can be made in multiple ways. Often, they are made using analytical instruments, such as MRI scanners, NMR spectrometers and mass spectrometry. These instruments can provide rich information on both the structure as well as the concentration of disease markers. Although these instruments have revolutionized modern medicine and can come to a sound diagnosis, they have a profound disadvantage: long processing and waiting times. | |
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Due to this disadvantage, biosensors have found their way into society. In contrast to analytical instruments, these biosensors can quickly diagnose disease, can be used on-site and are often easy to use. Unfortunately, a universal and modular approach for these biosensors has been lacking. Therefore, we devised to develop a universal membrane sensor for biosensors, which we call Clickable Outer Membrane Biosensors, shortly COMBs. | Due to this disadvantage, biosensors have found their way into society. In contrast to analytical instruments, these biosensors can quickly diagnose disease, can be used on-site and are often easy to use. Unfortunately, a universal and modular approach for these biosensors has been lacking. Therefore, we devised to develop a universal membrane sensor for biosensors, which we call Clickable Outer Membrane Biosensors, shortly COMBs. | ||
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Revision as of 11:49, 12 September 2015
Clickable Outer Membrane Biosensors (COMBs)
- An aptamer-based approach to a universal and modular biosensor platform
The technology and knowledge available to us today have led to ground-breaking drug discoveries. For many diseases, however, the foundation of curing lies not exclusively in the availability of these sophisticated drugs, but rather in an accurate and early diagnosis. An illustrating example is intestinal cancer. The survival rate of patients diagnosed with intestinal cancer in the early stage is 90%, whereas the survival rate of patients diagnosed in the critical stage is a meagre 13% [1]. An accurate and early diagnosis thus saves lives.
Such diagnoses can be made in multiple ways. Often, they are made using analytical instruments, such as MRI scanners, NMR spectrometers and mass spectrometry. These instruments can provide rich information on both the structure as well as the concentration of disease markers. Although these instruments have revolutionized modern medicine and can come to a sound diagnosis, they have a profound disadvantage: long processing and waiting times.
Due to this disadvantage, biosensors have found their way into society. In contrast to analytical instruments, these biosensors can quickly diagnose disease, can be used on-site and are often easy to use. Unfortunately, a universal and modular approach for these biosensors has been lacking. Therefore, we devised to develop a universal membrane sensor for biosensors, which we call Clickable Outer Membrane Biosensors, shortly COMBs.