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The technology and knowledge available to us today have led to ground-breaking drug discoveries. For many diseases, however, the foundation of curing lies not exclusively in the availability of these sophisticated drugs, but rather in an accurate and early diagnosis <image src="https://static.igem.org/mediawiki/2015/8/87/TU_Eindhoven_Ingeklapt.png" id="spoilerbutton1" class="spoilerbutton" />.<div class="spoiler" id="spoiler1">
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Ground-breaking drug discoveries are at the forefront of society. The success rate of curing, however, highly depends on an accurate and early diagnosis of disease <image src="https://static.igem.org/mediawiki/2015/8/87/TU_Eindhoven_Ingeklapt.png" id="spoilerbutton1" class="spoilerbutton" />.<div class="spoiler" id="spoiler1">
 
An illustrating example is intestinal cancer. The survival rate of patients diagnosed with intestinal cancer in the early stage is 90%, whereas the survival rate of patients diagnosed in the critical stage is a meagre 13% [1]. An accurate and early diagnosis saves lives.
 
An illustrating example is intestinal cancer. The survival rate of patients diagnosed with intestinal cancer in the early stage is 90%, whereas the survival rate of patients diagnosed in the critical stage is a meagre 13% [1]. An accurate and early diagnosis saves lives.
 
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Analytical instruments such as MRI scanners, NMR spectrometers and mass spectrometry can provide rich information on the structure and concentration of disease markers, enabling sound diagnoses. Although these instruments have thereby revolutionized modern medicine, they have a profound disadvantage: samples often need to be pre-treated and patients have to face long waiting times.
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An approach to diagnose disease is through the use of analytical instruments. Even though these instruments provide rich information which can lead to sound diagnoses, these instruments suffer from a profound disadvantage: samples need to be pre-treated and patients face long waiting times. To overcome the long processing and waiting times, biosensors have been developed. These biosensors can be used on-site and are easy to use, but a universal approach in these biosensors is lacking. That is where we come in, as we have developed a universal membrane sensor for biosensors, which we call Clickable Outer Membrane Biosensors, shortly COMBs.  
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Due to this disadvantage, biosensors have found their way into society. In contrast to analytical instruments, these biosensors can quickly diagnose disease, can be used on-site and are often easy to use. Many of these biosensors have already been developed, but a universal approach is lacking. That is where we come in, as we have developed a universal membrane sensor for biosensors, which we call Clickable Outer Membrane Biosensors, shortly COMBs.  
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Revision as of 12:39, 12 September 2015






Clickable Outer Membrane Biosensors (COMBs)

- An aptamer-based approach to a universal and modular biosensor platform


Ground-breaking drug discoveries are at the forefront of society. The success rate of curing, however, highly depends on an accurate and early diagnosis of disease .
An illustrating example is intestinal cancer. The survival rate of patients diagnosed with intestinal cancer in the early stage is 90%, whereas the survival rate of patients diagnosed in the critical stage is a meagre 13% [1]. An accurate and early diagnosis saves lives.
An approach to diagnose disease is through the use of analytical instruments. Even though these instruments provide rich information which can lead to sound diagnoses, these instruments suffer from a profound disadvantage: samples need to be pre-treated and patients face long waiting times. To overcome the long processing and waiting times, biosensors have been developed. These biosensors can be used on-site and are easy to use, but a universal approach in these biosensors is lacking. That is where we come in, as we have developed a universal membrane sensor for biosensors, which we call Clickable Outer Membrane Biosensors, shortly COMBs.