Difference between revisions of "Team:NTU-LIHPAO-Taiwan/Modeling/Conclusion"
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| − | <div class="Text1"> | + | <div class="Text1">Modeling Summary</div> |
| − | <div class="Text2" id="First"> | + | <div class="Text2" id="First">Hypothesis</div> |
<div class="Text3"> | <div class="Text3"> | ||
After orally ingested, certain amounts of modified probiotic <i>L. casei</i> can survive under acidic condition when passing through the stomach. Owning to gastric acid, bile acid and digestive enzymes, the presence of these bacteria in the intestinal tract only last for a limited time, and then are washed out in faeces.<a href="#Reference1">[1]</a> During the process of transition and temporary colonization, CPP-PYY complexes are produced and exert the following effect. | After orally ingested, certain amounts of modified probiotic <i>L. casei</i> can survive under acidic condition when passing through the stomach. Owning to gastric acid, bile acid and digestive enzymes, the presence of these bacteria in the intestinal tract only last for a limited time, and then are washed out in faeces.<a href="#Reference1">[1]</a> During the process of transition and temporary colonization, CPP-PYY complexes are produced and exert the following effect. | ||
| + | </div> | ||
| + | <div class="Text2" id="First">Conclusion</div> | ||
| + | <div class="Text3"> | ||
| + | Ideally, the optimal concentration of PYY is 0.1 μg/L for appetite suppression, giving little side effect. Here we performed the simulation with 109 of total <i>L. casei</i> intake, and 10-10 μg/min of CPP-PYY complex production rate per <i>L. casei</i>. The results is shown below. | ||
| + | By building the model for simulation step by step, we summarized the general formula with varies parameters to determine the dose response : | ||
| + | [Final concentration of PYY in the blood (μg/L)] = 11745 × [Total <i>L. casei</i> intake] × [Distribution ratio of <i>L. casei</i>] × [CPP-PYY complex production rate per <i>L. casei</i> (μg/min)] | ||
| + | This general formula is based on one-dose response, and continuous drug intake should be further modified by successive accumulation for determining the appetite suppression effect. | ||
| + | |||
</div> | </div> | ||
Revision as of 19:08, 12 September 2015
- Prototype
- Main Part
- Test Part
- Reference
Modeling Summary
Hypothesis
After orally ingested, certain amounts of modified probiotic L. casei can survive under acidic condition when passing through the stomach. Owning to gastric acid, bile acid and digestive enzymes, the presence of these bacteria in the intestinal tract only last for a limited time, and then are washed out in faeces.[1] During the process of transition and temporary colonization, CPP-PYY complexes are produced and exert the following effect.
Conclusion
Ideally, the optimal concentration of PYY is 0.1 μg/L for appetite suppression, giving little side effect. Here we performed the simulation with 109 of total L. casei intake, and 10-10 μg/min of CPP-PYY complex production rate per L. casei. The results is shown below.
By building the model for simulation step by step, we summarized the general formula with varies parameters to determine the dose response :
[Final concentration of PYY in the blood (μg/L)] = 11745 × [Total L. casei intake] × [Distribution ratio of L. casei] × [CPP-PYY complex production rate per L. casei (μg/min)]
This general formula is based on one-dose response, and continuous drug intake should be further modified by successive accumulation for determining the appetite suppression effect.
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