Difference between revisions of "Team:NJU-China"

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{{NJU-China}}
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<h1>The Opioid War</h1>
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<p>Opioids and opiates top the list of illicit drugs and cause the most burden of disease and drug-related deaths worldwide. The goal of this project is to develop a strategy to treat opioid addiction. We prepared exosomes (nano-sized vesicles secreted by endogenous cells) from cell factory that was engineered to express a rabies viral glycoprotein peptide (specifically recognize and target neuronal cells) on the exosomal membrane surface. By filling the exosomes with siRNA of the mu opioid receptor (MOR, a primary target for opioids) and injecting the exosomes into mouse bloodstream, we detected efficient passage of the siRNA through blood-brain barrier and specific accumulation of the siRNA in mouse brain. Consequently, siRNA-loaded exosomes significantly reduced MOR mRNA and protein levels in mice. To show the therapeutic potential, siRNA-loaded exosomes strongly restrained morphine-induced conditioned place preference in mice. This project may open up new avenues for future treatment of drug addiction. </p>
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    <TD width="73%" bgColor=#FFFFFF style="vertical-align:top;padding-left:80px;padding-right:80px;padding-top:50px;padding-bottom:50px;word-wrap:break-word;">
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你在火中涅槃,灵魂不死;你在花间长眠,记忆不消。绚烂的阳光是迎接你西去的光环,不知你独自一人去那方可会感到孤单?
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[一]魂去
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      起初听到你的死,我是愕然的。毕竟听说你的病情好了不少,却不料那只是最后的回光返照。
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      我没有流泪,甚至没有悲伤,脑子里只是混混沌沌的一团。死?那是我们所有人最后的归宿吧。或许于你更是能够减少痛苦,未尝不是一件好事。
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      一切被我想得太简单,甚至太过理所当然了。理智,真是一个可怕的局。
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[二]席间
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      小号、大鼓敲个不停,那种声音不得不说是一种噪音。良久声止,开始一个个念悼词。
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      我这时才发现,原来我并没有那么冷漠,缘是城市的喧嚣麻木了我的心。想起那年你的温言软语、慈爱笑容,泪竟是就这样忍不住地从眼眶中溢出了。我撇过头,不愿让人看见,嘴角仍是挂着笑容。
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      呵呵,我竟觉着在这葬礼上哭泣都是可耻的。望着周围人谈笑风生,我的心有点寒。到场的那么多人,究竟又有几个是真心的呢?可怜,还是可悲啊?
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      原来人可以铁石心肠这种程度,可毕竟他们中很多人比我和你的关系更近啊!听着那个花钱雇来哭的人呜咽,看着那人热泪纵横,我终是忍不住苦笑,竟是一个毫不相识的外人哭得最伤心。这是讽刺,还是笑话?
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  [三]送葬
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      你说,为什么他们还能那样淡然,可我偏偏忍不住泪流满面?为什么他们那个惊讶的表情让我竟是感到羞愧?好像自己做了什么惊天动地的事一样?
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      执着一根香,撒下一碗酒,三拜三叩,泪融于酒,我如若痴人。
 +
      照礼我是不必披麻戴孝的,只需戴着那顶白色的帽子即可。沿着幽僻的小路,我跟着吹着小号开路的队伍走在末尾。
 +
      风景甚好,埋在那棵大树底下,你会不会成为那树的枝,树的叶?
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[四]感怀
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      死生有命,无可更改。谋事在人,成事在天。任你生前浮华万千,到头来不过一抔尘土,一捧青灰。愿逝者安息,生者恬淡。
 +
      有时候我们看不到自己拥有的美好,直到失去才恍然叹息。逝者已矣,页已掀过,惜福、感恩,生活其实温暖如花。
 +
      花开半夏,倾尽繁华,愿你回眸半刹。你可听到我在同你夜话?
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Revision as of 04:44, 13 September 2015

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你在火中涅槃,灵魂不死;你在花间长眠,记忆不消。绚烂的阳光是迎接你西去的光环,不知你独自一人去那方可会感到孤单? [一]魂去 起初听到你的死,我是愕然的。毕竟听说你的病情好了不少,却不料那只是最后的回光返照。 我没有流泪,甚至没有悲伤,脑子里只是混混沌沌的一团。死?那是我们所有人最后的归宿吧。或许于你更是能够减少痛苦,未尝不是一件好事。 一切被我想得太简单,甚至太过理所当然了。理智,真是一个可怕的局。 [二]席间 小号、大鼓敲个不停,那种声音不得不说是一种噪音。良久声止,开始一个个念悼词。 我这时才发现,原来我并没有那么冷漠,缘是城市的喧嚣麻木了我的心。想起那年你的温言软语、慈爱笑容,泪竟是就这样忍不住地从眼眶中溢出了。我撇过头,不愿让人看见,嘴角仍是挂着笑容。 呵呵,我竟觉着在这葬礼上哭泣都是可耻的。望着周围人谈笑风生,我的心有点寒。到场的那么多人,究竟又有几个是真心的呢?可怜,还是可悲啊? 原来人可以铁石心肠这种程度,可毕竟他们中很多人比我和你的关系更近啊!听着那个花钱雇来哭的人呜咽,看着那人热泪纵横,我终是忍不住苦笑,竟是一个毫不相识的外人哭得最伤心。这是讽刺,还是笑话? [三]送葬 你说,为什么他们还能那样淡然,可我偏偏忍不住泪流满面?为什么他们那个惊讶的表情让我竟是感到羞愧?好像自己做了什么惊天动地的事一样? 执着一根香,撒下一碗酒,三拜三叩,泪融于酒,我如若痴人。 照礼我是不必披麻戴孝的,只需戴着那顶白色的帽子即可。沿着幽僻的小路,我跟着吹着小号开路的队伍走在末尾。 风景甚好,埋在那棵大树底下,你会不会成为那树的枝,树的叶? [四]感怀 死生有命,无可更改。谋事在人,成事在天。任你生前浮华万千,到头来不过一抔尘土,一捧青灰。愿逝者安息,生者恬淡。 有时候我们看不到自己拥有的美好,直到失去才恍然叹息。逝者已矣,页已掀过,惜福、感恩,生活其实温暖如花。 花开半夏,倾尽繁华,愿你回眸半刹。你可听到我在同你夜话?