Difference between revisions of "Team:WHU-China/Description"

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                 <ul id="tit2">
 
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                     <li><a href="javascript:return false;">Overview</a></li>
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                     <li><a href="https://2015.igem.org/Team:WHU-China/Description">Overview</a></li>
 
                     <li><a href="javascript:return false;">Design</a></li>
 
                     <li><a href="javascript:return false;">Design</a></li>
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                     <li><a href="javascript:return false;">Criticality Detector</a></li>
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                     <li><a href="https://2015.igem.org/Team:WHU-China/Criticality">Criticality Detector</a></li>
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                     <li><a href="javascript:return false;">Binary System</a></li>
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                     <li><a href="javascript:return false;">Dental Caries Prevention</a></li>
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                     <li><a href="https://2015.igem.org/Team:WHU-China/DentalCP">Dental Caries Prevention</a></li>
 
                     <li><a href="javascript:return false;">Results</a></li>
 
                     <li><a href="javascript:return false;">Results</a></li>
 
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                     <li><a href="https://2015.igem.org/Team:WHU-China/Basic_Parts">Basis Parts</a></li>
 
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                    <li><a href="https://2015.igem.org/Team:WHU-China/Safety">Safety</a></li>
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                     <li><a href="https://2015.igem.org/Team:WHU-China/Experiments">Protocols</a></li>
 
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                     <li><a href="https://2015.igem.org/Team:WHU-China/Practices">Meet ups</a></li>
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                     <li><a href="https://2015.igem.org/Team:WHU-China/SmileMates">Smile mates</a></li>
 
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                     <li><a href="https://2015.igem.org/Team:WHU-China/Modeling">Modeling</a></li>
 
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Revision as of 17:29, 14 September 2015

圆形 圆形

Overview

Criticality detection system, which we intend to construct, combines biosensor with signal converter. The work pattern is that the system receives the specific input signal and then generates pulse output when the input’s vibration exceeds predefined threshold (see Fig.1).

Overview

The detection of threshold is achieved with the help of a red-light-sensing part and a specially designed negative feedback circuit. A fusion protein called Cph8 senses red light and activates three OmpC promoters when red light intensity in the environment drops below a threshold. An output (GFP) keeps being generated until it is inhibited by the negative feedback circuit we built (see Fig.2). A relatively long feedback circuit was designed to generate pulse of good intensity and modularity. Considering the system construction and work pattern, our criticality detection system can function as a pulse generator, a signal filter and so on. In our case, the module is proved to have potential application in biocomputer development and health care. Our system can be used as a signal filter in the biocomputer development. Combining criticality detection system with pairs of integrase and excisionase, we set up a binary counting system composed of some two-state latch modules that switch between states “0” and “1”. Working as a pulse generator in dental caries prevention, the system release a suitable amount of antimicrobial peptides by adjusting the length and intensity of the pulse and maintain the population of oral flora at a satisfactory level.