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Revision as of 00:23, 16 September 2015
Modelling Genomic Effects of CRISPR/Cas9
This page contains all our information about the Cas9 Dynamics Model.
Model Formation
Biology of Genomic Cutting, Repair and Deletions by CRISPR/Cas9
Assumptions
Pseudocode
Parameters
Talk about where all the probabilities come from
Results
Model Validation
Include notes on how the model matches reality/our expectations of reality in this section.
Simulate w/ targets that mismatch to different extents.
Effect of sgRNA Strength
Matt visualizations for different sgRNAs.
Graph of 3 different sgRNA designs of different strengths, show % functional
Importance of Large Deletions
Include notes on how the model matches reality/our expectations of reality in this section.
Effect of Cas9 Concentration
Include notes on how the model matches reality/our expectations of reality in this section.
Plant Defence by CRISPR/Cas9
Show % funcitonal for P6/time over many simulations.