Difference between revisions of "Team:ZJU-China"

 
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<h2> This is ZJU-iGEM 2015! </h2>
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<h4>Project description: </h4>
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<p>Termites are widely recognized as the 5th pest around the world, based on its astonishing number and incredible damage towards wood. Given that a termite weighed 1 gram, then everyone should own 500 thousand termites! Owing to their wood-eating habits, termites are terminators of crops, trees, buildings, river dams；and more oftenly, spoil people’s life.</p>
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<p>The traditional way of killing termites is to release imidaclorprid or mirex directly to the environment, which may contribute to hidden troubles to the ecosystem. ZJU iGEMers coated adapted soil bacterium Streptomyces, which secreted Avermectin to kill termites. Avermectin is a kind of antibiotics which do little harm to human beings and other mammals, but it is a strong inhibitor to termites. A slight trace of Avermectin can be effective of killing termites. We develop 3 to 4 functional gene circuits to enhance the production of Avermectin. In order to eliminate the termites, we choose two kinds of toxins which are safe and environmentally friendly. Separately over expressed in E.coli and another host, these toxins were then delivered to the termites by the cell carrier.</p>
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<div class="flick-sub-text">Termites are recognized as the 5th pest around the world, based on its astonishing number and incredible damage towards wood. Owing to their wood-eating habits, termites are terminators of crops, trees, buildings, river dams；and spoil people’s life. ZJU-CHINA 2015 has created TERMITE TERMINATOR, a genetically modified  toxins expression system with a delivery carrier CNC (cellulose nanocrystals), capable of exterminate whole nest of termites based on their trophallaxis in an indoor designed device.  
 
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<img src="http://r.photo.store.qq.com/psb?/94e3c2c3-1497-4fb2-943b-040f48fcf0b3/xwSf3qIbFvA7s322PxSxMjen9873MLdZelaQtWNByMw!/o/dE0AAAAAAAAA&bo=gAKAAsUCxQIFACM!&rf=viewer_4" />
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<div class="flick-sub-text"> To prevent the bacteria from being released into environment or simply being degraded without completing its mission, and to reduce termites’ resistance towards toxins; we designed bacteria carriers self-assembled from the generated cellulose nanocrystals (CNC).
 
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  <!--<div class="flick-title">Editable via Javascript or CSS</div>-->
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<div class="flick-sub-text" style="float:left">We are always exploring a more convenient and intuitive new way to promote synthetic biology and iGEM projects better to the broader public. So, this time we have created Poly Cards, a new public education tool to communicate synthetic biology and iGEM projects.
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The cards have been successfully incorporated biobricks and iGEM projects.
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For better practice of Poly Cards, cooperating with Zhejiang China Association for Science and Technology, we held a Syn-bio Share.
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<p>In order to attract termites and to deliver Avermectin successfully only into intestine, they assembled cellulose nanocrystals as capsule shells. What is terrific is that termites love cellulose and workers will regard the cellulose as food and bring them to the queen and larvae in a non-defensive way. In this way, we could root out the whole nest gradually.</p>
 
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<p>Then we change the system into a safe and workable device to imitate the real use procedure in our lab. To make sure the safety and security , we also come up with several ways to control the ecological hazard to the minimal range.</p>
 
 
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<div class="wrap" >
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<h2 class="hh2">INTRODUCTION</h2>
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<div class="block" style="background-color:#fff;cursor:default " data-scale="5"  >
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  <h2 class="intro-in-h" >Why we choose termites?</h2>
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  <a href="https://2015.igem.org/Team:ZJU-China/Project/Termite_Issue">
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        <p class="intro-in-p" style="cursor:pointer">
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Termites are widely recognized as the 5th pest around the world,
 +
  based on its astonishing number and incredible damage towards wood.
 +
  Given that a termite weighed 1 gram,
 +
  then everyone should own 500 thousand termites!
 +
  Owing to their wood-eating habits,
 +
  termites are terminators of crops,
 +
  trees, buildings, river dams；
 +
  and more often, spoil people’s life.
 +
  </p></a>
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  </div>
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  </div>
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      <div class="col-md-6">
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  <a href="https://2015.igem.org/Team:ZJU-China/Project">
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          <div class="block" style="background-color:#fff"  data-scale="0.2" data-skew="90deg,90deg">
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  <h2 class="intro-in-h">Our new system of termite terminator</h2>
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  <p class="intro-in-p">
 +
  IGEM ZJU-CHINA 2015 has created TERMITE TERMINATOR,
 +
  a genetically modified  toxins expression system with a
 +
  delivery carrier CNC (cellulose nanocrystals),
 +
  capable of trapping termites based on their trophallaxis.
 +
  </p>
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</a>
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<a href="https://2015.igem.org/Team:ZJU-China/Results">
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    <h2 class="intro-in-h">Results and Application</h2>
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  <p class="intro-in-p">
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  We have successfully overexpressed avermectins in streptomyces avermitilis and achieved toxins manufacture in E.coli to kill termites.
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  To trap effectively, we prepared cellulose nanocrystals (CNC),
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  and generated the nanofibrous microspheres self‐assembled from CNC as bacteria carriers.
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  Additionally, a device has been designed. With the help of modeling,
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  preliminary experience of the device has been made to prove its effect.   </p>
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  <h2 class="intro-in-h" style="color:red;margin-bottom:0">For better</h2>
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  <ul class="ch-grid">
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                              <a href="https://2015.igem.org/Team:ZJU-China/Modeling"><h2>For better application effect</h2></a>
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                            <p>We are termite terminator. Our completed models aim at product manufacturing and devices placing , which play a part in application . With artificial intelligence group simulation(Model 1) , customers obtain the optimal bait location . With the Physicochemistry process (Model 2 and model 3) we present , Manufacturers can control their production accurately by adjusting key factors .</p>
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                                  <a href="https://2015.igem.org/Team:ZJU-China/Practices/Application/Future"><h2>For better use in the future</h2></a>
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                              <p>Based on current references, ZJU-CHINA 2015 designed the indoor device to achieve monitor, trap, and terminate termites successfully.Focusing on the potential wider impacts of our application, a series of warnings have been added to the Instruction Manual can be proposed. In the commercial part, we made the promotion part to smooth future consumers' acceptance of our product.
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</p>
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                              <a href="https://2015.igem.org/Team:ZJU-China/Entrepreneurship"><h2>For better promotion</h2></a>
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                              <p>We have made a systematic structure for human practice activities. Our human practice work can be divided into four parts-----Society, Application, Public Promotion and Collaboration. For better promotion of synthetic biology and our project, we designed an efficient multifunctional tool for the promotion of synthetic biology-------Poly Cards! We got wonderful feedbacks to our human practice activities from the public. See our Outreach web to know more information!</p>
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                            <a href="https://2015.igem.org/Team:ZJU-China/Practices/Cooperate/Senergene/first"><h2>For better project and scenarios</h2></a>
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    <p>IGEM is not only a scientific competition. Since we are casting the synthetic biology on the real world problem, it forces us to consider about the ethical, legal, religious and social problems. Thus we collaborate with Synenergene, who aims at fostering responsible research and innovation in synthetic biology. The writing process of application scenarios and techno-moral vignettes prompts us to ground the plausibility and desirability of applications envisaged in our iGEM project.</a></p>
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Latest revision as of 15:14, 17 September 2015

  • Termites are recognized as the 5th pest around the world, based on its astonishing number and incredible damage towards wood. Owing to their wood-eating habits, termites are terminators of crops, trees, buildings, river dams；and spoil people’s life. ZJU-CHINA 2015 has created TERMITE TERMINATOR, a genetically modified toxins expression system with a delivery carrier CNC (cellulose nanocrystals), capable of exterminate whole nest of termites based on their trophallaxis in an indoor designed device.
  • To prevent the bacteria from being released into environment or simply being degraded without completing its mission, and to reduce termites’ resistance towards toxins; we designed bacteria carriers self-assembled from the generated cellulose nanocrystals (CNC).
  • We are always exploring a more convenient and intuitive new way to promote synthetic biology and iGEM projects better to the broader public. So, this time we have created Poly Cards, a new public education tool to communicate synthetic biology and iGEM projects. The cards have been successfully incorporated biobricks and iGEM projects. For better practice of Poly Cards, cooperating with Zhejiang China Association for Science and Technology, we held a Syn-bio Share.

INTRODUCTION

Why we choose termites?

Termites are widely recognized as the 5th pest around the world, based on its astonishing number and incredible damage towards wood. Given that a termite weighed 1 gram, then everyone should own 500 thousand termites! Owing to their wood-eating habits, termites are terminators of crops, trees, buildings, river dams； and more often, spoil people’s life.

Our new system of termite terminator

IGEM ZJU-CHINA 2015 has created TERMITE TERMINATOR, a genetically modified toxins expression system with a delivery carrier CNC (cellulose nanocrystals), capable of trapping termites based on their trophallaxis.

Results and Application

We have successfully overexpressed avermectins in streptomyces avermitilis and achieved toxins manufacture in E.coli to kill termites. To trap effectively, we prepared cellulose nanocrystals (CNC), and generated the nanofibrous microspheres self‐assembled from CNC as bacteria carriers. Additionally, a device has been designed. With the help of modeling, preliminary experience of the device has been made to prove its effect.

For better

  • For better application effect

    We are termite terminator. Our completed models aim at product manufacturing and devices placing , which play a part in application . With artificial intelligence group simulation(Model 1) , customers obtain the optimal bait location . With the Physicochemistry process (Model 2 and model 3) we present , Manufacturers can control their production accurately by adjusting key factors .

  • For better use in the future

    Based on current references, ZJU-CHINA 2015 designed the indoor device to achieve monitor, trap, and terminate termites successfully.Focusing on the potential wider impacts of our application, a series of warnings have been added to the Instruction Manual can be proposed. In the commercial part, we made the promotion part to smooth future consumers' acceptance of our product.

  • For better promotion

    We have made a systematic structure for human practice activities. Our human practice work can be divided into four parts-----Society, Application, Public Promotion and Collaboration. For better promotion of synthetic biology and our project, we designed an efficient multifunctional tool for the promotion of synthetic biology-------Poly Cards! We got wonderful feedbacks to our human practice activities from the public. See our Outreach web to know more information!

  • For better project and scenarios

    IGEM is not only a scientific competition. Since we are casting the synthetic biology on the real world problem, it forces us to consider about the ethical, legal, religious and social problems. Thus we collaborate with Synenergene, who aims at fostering responsible research and innovation in synthetic biology. The writing process of application scenarios and techno-moral vignettes prompts us to ground the plausibility and desirability of applications envisaged in our iGEM project.




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