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<h2> Team Danzi-Kesh 8</h2>
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      <nav class="w-nav-menu nav-menu" role="navigation"><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Team">Team</a><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Description">Project</a><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Parts">Parts</a><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Notebook">Notebook</a><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Attributions">Attributions&nbsp;</a><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Collaborations">Collaborations</a><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Practices">Human Practices</a><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Safety">Safety</a><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Modeling">Modeling</a><a class="w-nav-link nav-link" href="https://2015.igem.org/Team:Danzi_Kesh_8/Entrepreneurship">Entrepreneurship</a>
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          <h1 class="hero-title" data-ix="hero-title">Welcome to&nbsp;<strong>ALERGLN</strong></h1>
  
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<h4>Team characteristics: </h4>
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          <h1 class="hero-title word" data-ix="hero-title-2">Research,</h1>
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<p>Team DANZI-KESH-8 is a biotechnology class from Danziger High School, the high school is situated in the northernmost part of Israel. The school is located in a small town Kiryat Shmona.</p>
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          <h1 class="hero-title word" data-ix="hero-title-3">STUDY, Fun</h1>
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<P>We, 23 students aged 16 and majoring in biotechnology, may be young but full of ambition and motivation for success and learning different fields of science. The entire school staff is recruited together with us to prepare for competition - the English teacher, science teacher, math teacher, and of course the school administration.</p>
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          <h1 class="hero-title word" data-ix="hero-title-4">&amp;&nbsp;Creativity</h1>
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<h4>The Project's Goal: </h4>
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<li>Develop an innovative biological method for identifying gluten in food.</li>
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<li>Assuming that the system is proven to be successful we can pack it into a personal kit for a quick check of the presence of gluten in food.</li>
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<li>To promote as much as possible the legal treatment of food allergy cases in the school education system, meaning, to require schools to offer on the menu gluten-free food to ensure equality for students who are sensitive to gluten.</li>
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          <h1 class="hero-title title-2" data-ix="hero-title-6">we are Team DANZI-KESH-8,<br> a
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biotechnology class from Danziger High School,&nbsp;<br>Kiryat Shmona, Israel
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.</h1>
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      <h2 class="section-title subtitle">Alergln project</h2>
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      <p><strong>The aim
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of our project</strong> is to create a personal kit, one that identifies gluten in food, reliably and in reasonable time. This kit will allow easing the celiac patient’s life and reducing their expenses to a great extent.&nbsp;</p>
 +
      <p><strong>The
 +
"Alergln" Kit</strong> is based on a fascinating innovative technology in the diagnostic world, just as the kit to identify pregnancy brought with it a series of scientific technology; equally, this kit brings innovation and a breakthrough in a way of thinking and designing the kit. In the future, we believe that the idea can be implemented and utilized as well in areas to identify other substances, not necessarily food materials.</p>
 +
      <p><strong>The
 +
"Alergln Project"</strong> was created after the realization that the number of people diagnosed in having gluten sensitivity (celiac disease) increases from year to year. The number of diagnosed celiac patient’s increases annually worldwide mostly due to awareness of this phenomenon. This awareness eases and enables many people real quality of life without the horrendous stomach pains. Celiac disease patients are not treated with drugs because the drug is not available; these patients simply avoid eating gluten. Therefore, they must verify whether the food they intend eating has gluten or not. The scales to check are often complicated and not necessarily accurate.
 +
      </p>
 +
      <p><strong>The
 +
"Alergln" kit</strong> will serve the above population, prevent them from concern for the presence of gluten in food and can eat with peace of mind and <strong>without
 +
worrying about their lives.</strong>
 +
      </p>
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      <p><strong>The
 +
success of the project</strong> will allow patients to eat foods that "may contain gluten," but there is no gluten, the difference in prices is very high and hence the kit cancels the presence of gluten in regular foods and allows the patient to eat without any concern, and at a lower cost.&nbsp;</p>
 +
      <div class="intro-button-wrapper">
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        <div class="intro-button-line"></div><a class="button intro-button" href="https://2015.igem.org/Team:Danzi_Kesh_8/Description">Discover more about our Project</a>
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      <h2 class="section-title subtitle">Team DANZI-KESH-8</h2>
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      <p><strong>Team DANZI-KESH-8</strong> is a biotechnology class from Danziger High School, the high school is situated in the northernmost part of Israel. The school is located in a small town Kiryat Shmona.</p>
 +
      <p>We, 23 students aged 16 and majoring in biotechnology, may be young but full of ambition and motivation for success and learning different fields of science. The entire school staff is recruited together with us to prepare for competition - the English teacher, science teacher, math teacher, and of course the school administration.</p><a class="link below-paragraph" href="#gallery">Watch our journey album</a>
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<h4>The considerations that motivated us to make the decision:</h4>
 
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<li>The scientific design of the method is fascinating and innovative in our opinion, and can create a turnaround in the field of diagnostics. So far, most of the materials identification systems based on planning that includes antibodies, this kit includes the use of transmembrane proteins, and this is the innovation. </li>
 
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<li>We would like to create conceptual change in relation to a person who is sensitive to a specific food component. To give the patient the ability to decide whether or not to buy a food product. The ability to control knowledge will be in the consumers' hands and not the food manufacturers. As of today, the majority of food products in Israel have a marking: "The product may contain allergic bodies". In most cases, the sick person will refrain from foodstuffs and buy a similar product at a much higher cost.  </li>
 
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<li>The State of Israel in 2016 does not give sufficient attention to nutritionally disabled people. We see this disability as a sort of cripple which requires some degree of legal reference. All students in the education system eat the same general menu - Kindergartens, elementary schools, high schools and even in academic institutions. None of these institutions address celiac patients/sufferers, for example - there is no alternative menu and allergic students have only one option, that is to look after himself. </li>
 
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<h4>The "Alergln kit" will:</h4>
 
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<ol>
 
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<li>To promote an innovative detection technique which is not based on antibodies but transmembrane protein. </li>
 
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<li>The laboratory team worked to identify transmembrane proteins that can be used as biosensors.</li>
 
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<li>On the 21/5, we announced a starting point at a conference which dealt entirely on synthetic biology. It was a major regional meeting that delved in contemporary research in this field along with the exposure of the iGEM competition to more students from the State Israel. iGEM teams attended the conference from the Technion, Ben Gurion University and the Technion's high school.</li>
 
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<li>To convey a preliminary survey for school children and adults about the necessity of the kit within the school and about addressing nutrition toward allergic people. </li>
 
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<li>Receiving the first shipment from the directors of iGEM. The laboratory team has begun producing plasmid where the genes will be cloned. </li>
 
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<li>Planning interviews with two people who are connected to the field.</li>
 
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<li>Genes were prepared in advance while performing a deliberate mutation in them. The goal to produce the margins of a suitable restriction site and a promoter strong enough to express the protein we are interested in.</li>
 
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<h4>Our project - Development of biosensors to detect food allergens</h4>
 
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<p>The focus is on developing a gluten binder protein.
 
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Principles - A protein changes conformation in response to ligand binding coupled to a reporter gene.
 
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The Gln_H protein is a protein which is able to detect glutamine.
 
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The two ends join a half-reporter enzyme called HAD. each half of the enzyme is attached a molecule such as color coded GFP.
 
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When the Gln H comes into contact with glutamine the closed ends, when the two halves of  HAD enzyme connect the enzyme becomes active, followed by a color reaction which can be seen by the human eye.
 
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The source HAD enzymes comes from TERMOTOGA MARITIMA ,This bacteria is found in regions of hot springs and is therefore an extra Thermopile bacteria, and its enzymes are very stable.</p>
 
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Latest revision as of 09:32, 18 September 2015


Danzi

Welcome to ALERGLN

Research,

STUDY, Fun

& Creativity

we are Team DANZI-KESH-8,
a biotechnology class from Danziger High School, 
Kiryat Shmona, Israel .

Alergln project

The aim of our project is to create a personal kit, one that identifies gluten in food, reliably and in reasonable time. This kit will allow easing the celiac patient’s life and reducing their expenses to a great extent. 

The "Alergln" Kit is based on a fascinating innovative technology in the diagnostic world, just as the kit to identify pregnancy brought with it a series of scientific technology; equally, this kit brings innovation and a breakthrough in a way of thinking and designing the kit. In the future, we believe that the idea can be implemented and utilized as well in areas to identify other substances, not necessarily food materials.

The "Alergln Project" was created after the realization that the number of people diagnosed in having gluten sensitivity (celiac disease) increases from year to year. The number of diagnosed celiac patient’s increases annually worldwide mostly due to awareness of this phenomenon. This awareness eases and enables many people real quality of life without the horrendous stomach pains. Celiac disease patients are not treated with drugs because the drug is not available; these patients simply avoid eating gluten. Therefore, they must verify whether the food they intend eating has gluten or not. The scales to check are often complicated and not necessarily accurate.

The "Alergln" kit will serve the above population, prevent them from concern for the presence of gluten in food and can eat with peace of mind and without worrying about their lives.

The success of the project will allow patients to eat foods that "may contain gluten," but there is no gluten, the difference in prices is very high and hence the kit cancels the presence of gluten in regular foods and allows the patient to eat without any concern, and at a lower cost. 

Discover more about our Project

Team DANZI-KESH-8

Team DANZI-KESH-8 is a biotechnology class from Danziger High School, the high school is situated in the northernmost part of Israel. The school is located in a small town Kiryat Shmona.

We, 23 students aged 16 and majoring in biotechnology, may be young but full of ambition and motivation for success and learning different fields of science. The entire school staff is recruited together with us to prepare for competition - the English teacher, science teacher, math teacher, and of course the school administration.

Watch our journey album
Discover more about our Team