Difference between revisions of "Team:Warwick/Modeling"
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<p><a href="BindingAffinity"><h5>Binding Affinity Modelling</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/6/66/Warwickmodeling5.png" align="right" height="100px" width="100px" border="1px"></p></p> </a> | <p><a href="BindingAffinity"><h5>Binding Affinity Modelling</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/6/66/Warwickmodeling5.png" align="right" height="100px" width="100px" border="1px"></p></p> </a> | ||
| − | A big problem biologists encounter is the uncertainty of | + | A big problem biologists encounter is the uncertainty of binding especially in our design where zinc fingers bind to their sites. Therefore it is important to come up with a model which can calculate the number of cell and zinc finger binding sites required for a given output. This page discusses this and shows a program designed to dictate concentrations for the biologists to use. |
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<p><a href="Modelling4"><h5>DNA Beading Model</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/a/a0/WarwickBead_Drawing.png" align="right" height="100px" width="100px" border="1px"></p></p> </a> | <p><a href="Modelling4"><h5>DNA Beading Model</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/a/a0/WarwickBead_Drawing.png" align="right" height="100px" width="100px" border="1px"></p></p> </a> | ||
| − | Once we had a method of calculating the concentration of cells needed we had to model the number of cells required to make a certain shape. We also needed to invent a novel approach to creating 2D shapes using cells, this page discusses | + | Once we had a method of calculating the concentration of cells needed we had to model the number of cells required to make a certain shape. We also needed to invent a novel approach to creating 2D shapes using cells, this page discusses binding them to a longer string of DNA to form a pattern. |
<p><img src="https://static.igem.org/mediawiki/2015/2/29/Warwickbubbles2.png" height="120px" width="800px" border="1px"></p> | <p><img src="https://static.igem.org/mediawiki/2015/2/29/Warwickbubbles2.png" height="120px" width="800px" border="1px"></p> | ||
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<p><a href="modelling3"><h5>Tetrahedron Construction</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/0/05/WarwickCaddy.png" align="right" height="100px" width="100px" border="1px"></p></p> </a> | <p><a href="modelling3"><h5>Tetrahedron Construction</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/0/05/WarwickCaddy.png" align="right" height="100px" width="100px" border="1px"></p></p> </a> | ||
| − | The previous model of using DNA as a glue could create 3D shapes but would need vast amounts of unique zinc fingers. This wasn't possible with our time frame so we | + | The previous model of using DNA as a glue could create 3D shapes but would need vast amounts of unique zinc fingers. This wasn't possible with our time frame so we came up with a model which could create a 3D structure from the minimum amount of unique DNA using tetrahedrons as a base to build from. Cells would then be bound to the outside.<br> |
| − | <p><img src="https://static.igem.org/mediawiki/2015/ | + | <p><img src="https://static.igem.org/mediawiki/2015/b/be/Warwickbubbles5.png" height="120px" width="800px" border="1px"></p> |
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| + | <p><a href="Modelling1"><h5>NTNU Collaboration</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/1/13/Warwickntunuloo.png" align="right" height="100px" width="100px" border="1px"></p></p> | ||
| + | </a> | ||
| + | We dcided to get help for some of the modelling and NTNU were kind enough to oblige. This model deals with calculating bonding and binding affinities.<br><br> | ||
| + | <p><img src="https://static.igem.org/mediawiki/2015/4/4f/Warwickbubbles9.png" height="120px" width="800px" border="1px"></p> | ||
Latest revision as of 10:10, 18 September 2015
