Difference between revisions of "Team:Warwick/Modeling"

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<p><a href="BindingAffinity"><h5>Binding Affinity Modelling</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/6/66/Warwickmodeling5.png" align="right" height="100px" width="100px" border="1px"></p></p> </a>

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A big problem biologists encounter is the uncertainty of ~~bonding~~ especially in our design where zinc fingers bind to their sites. Therefore it is important to come up with a model which can calculate the number of cell and zinc finger binding sites required for a given output. This page discusses this and shows a program designed to dictate concentrations for the biologists to use.

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A big problem biologists encounter is the uncertainty of binding especially in our design where zinc fingers bind to their sites. Therefore it is important to come up with a model which can calculate the number of cell and zinc finger binding sites required for a given output. This page discusses this and shows a program designed to dictate concentrations for the biologists to use.

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<p><a href="Modelling4"><h5>DNA Beading Model</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/a/a0/WarwickBead_Drawing.png" align="right" height="100px" width="100px" border="1px"></p></p> </a>

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Once we had a method of calculating the concentration of cells needed we had to model the number of cells required to make a certain shape. We also needed to invent a novel approach to creating 2D shapes using cells, this page discusses ~~bonding~~ them to a longer string of DNA to form a pattern.

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Once we had a method of calculating the concentration of cells needed we had to model the number of cells required to make a certain shape. We also needed to invent a novel approach to creating 2D shapes using cells, this page discusses binding them to a longer string of DNA to form a pattern.

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<p><a href="modelling3"><h5>Tetrahedron Construction</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/0/05/WarwickCaddy.png" align="right" height="100px" width="100px" border="1px"></p></p> </a>

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The previous model of using DNA as a glue could create 3D shapes but would need vast amounts of unique zinc fingers. This wasn't possible with our time frame so we ~~cam~~ up with a model which could create a 3D structure from the minimum amount of unique DNA using tetrahedrons as a base to build from. Cells would then be bound to the outside.<br>

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The previous model of using DNA as a glue could create 3D shapes but would need vast amounts of unique zinc fingers. This wasn't possible with our time frame so we came up with a model which could create a 3D structure from the minimum amount of unique DNA using tetrahedrons as a base to build from. Cells would then be bound to the outside.<br>

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<p><a href="Modelling1"><h5>NTNU Collaboration</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/1/13/Warwickntunuloo.png" align="right" height="100px" width="100px" border="1px"></p></p>

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</a>

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We dcided to get help for some of the modelling and NTNU were kind enough to oblige. This model deals with calculating bonding and binding affinities.<br><br>

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Difference between revisions of "Team:Warwick/Modeling"

Latest revision as of 10:10, 18 September 2015

Open Menu

Modelling

Binding Affinity Modelling

DNA Beading Model

DNA Origami Glue Modelling

Cell Growth Interactions

Tetrahedron Construction

Cube Construction

3D Lithography

NTNU Collaboration

CONTACT US

GET SOCIAL

ABOUT US

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 <!-- CONTENT
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 <div class="row">
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@@ Line 41: / Line 41: @@
 <p><a href="BindingAffinity"><h5>Binding Affinity Modelling</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/6/66/Warwickmodeling5.png" align="right" height="100px" width="100px" border="1px"></p></p> </a>
-A big problem biologists encounter is the uncertainty of bonding especially in our design where zinc fingers bind to their sites. Therefore it is important to come up with a model which can calculate the number of cell and zinc finger binding sites required for a given output. This page discusses this and shows a program designed to dictate concentrations for the biologists to use.
+A big problem biologists encounter is the uncertainty of binding especially in our design where zinc fingers bind to their sites. Therefore it is important to come up with a model which can calculate the number of cell and zinc finger binding sites required for a given output. This page discusses this and shows a program designed to dictate concentrations for the biologists to use.
@@ Line 58: / Line 58: @@
 <p><a href="Modelling4"><h5>DNA Beading Model</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/a/a0/WarwickBead_Drawing.png" align="right" height="100px" width="100px" border="1px"></p></p> </a>
-Once we  had a method of calculating the concentration of cells needed we had to model the number of cells required to make a certain shape. We also needed to invent a novel approach to creating 2D shapes using cells, this page discusses bonding them to a longer string of DNA to form a pattern.
+Once we  had a method of calculating the concentration of cells needed we had to model the number of cells required to make a certain shape. We also needed to invent a novel approach to creating 2D shapes using cells, this page discusses binding them to a longer string of DNA to form a pattern.
 <p><img src="https://static.igem.org/mediawiki/2015/2/29/Warwickbubbles2.png" height="120px" width="800px" border="1px"></p>
@@ Line 91: / Line 91: @@
 <p><a href="modelling3"><h5>Tetrahedron Construction</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/0/05/WarwickCaddy.png" align="right" height="100px" width="100px" border="1px"></p></p> </a>
-The previous model of using DNA as a glue could create 3D shapes but would need vast amounts of unique zinc fingers. This wasn't possible with our time frame so we cam up with a model which could create a 3D structure from the minimum amount of unique DNA using tetrahedrons as a base to build from. Cells would then be bound to the outside.<br>
+The previous model of using DNA as a glue could create 3D shapes but would need vast amounts of unique zinc fingers. This wasn't possible with our time frame so we came up with a model which could create a 3D structure from the minimum amount of unique DNA using tetrahedrons as a base to build from. Cells would then be bound to the outside.<br>
-<p><img src="https://static.igem.org/mediawiki/2015/e/e7/Warwickbubbles6.png" height="120px" width="800px" border="1px"></p>
+<p><img src="https://static.igem.org/mediawiki/2015/b/be/Warwickbubbles5.png" height="120px" width="800px" border="1px"></p>
 <p>_______________________________________________________________________________________________________________________________________<p>
@@ Line 124: / Line 124: @@
+<p><a href="Modelling1"><h5>NTNU Collaboration</h5><p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/1/13/Warwickntunuloo.png" align="right" height="100px" width="100px" border="1px"></p></p>
+</a>
+We dcided to get help for some of the modelling and NTNU were kind enough to oblige. This model deals with calculating bonding and binding affinities.<br><br>
+<p><img src="https://static.igem.org/mediawiki/2015/4/4f/Warwickbubbles9.png" height="120px" width="800px" border="1px"></p>