Difference between revisions of "Team:NTU-LIHPAO-Taiwan/Modeling"

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{{NTU-LIHPAO-Taiwan}}
 
 
<html>
 
<html>
 +
<head>
  
−
<h2> Modeling</h2>
+
<script src="https://ajax.googleapis.com/ajax/libs/jquery/1.6.2/jquery.min.js"></script>
  
 +
<script type="text/javascript" charset="utf-8">
  
−
<div class="highlightBox">
+
//-----Hover Facebook Icon-----//
−
<h4>Note</h4>
+
$(document).ready(function(){
−
<p>In order to be considered for the <a href="https://2015.igem.org/Judging/Awards#SpecialPrizes">Best Model award</a>, you must fill out this page.</p>
+
$('#Facebook_icon_hover').hover(function () {
−
</div>
+
this.src = "https://static.igem.org/mediawiki/2015/3/35/NTU-Top-Facebook_icon2.png";
 +
}, function () {
 +
this.src = "https://static.igem.org/mediawiki/2015/9/98/NTU-Top-Facebook_icon1.png";
 +
});
 +
});
 +
 
 +
//-----Hover iGem Icon-----//
 +
$(document).ready(function(){
 +
$('#iGEM_icon_hover').hover(function () {
 +
this.src = "https://static.igem.org/mediawiki/2015/0/0a/NTU-Top-iGEM_icon2.png";
 +
}, function () {
 +
this.src = "https://static.igem.org/mediawiki/2015/1/1d/NTU-Top-iGEM_icon1.png";
 +
});
 +
});
 +
 
 +
//-----Hover NTU Icon-----//
 +
$(document).ready(function(){
 +
$('#NTU_icon_hover').hover(function () {
 +
this.src = "https://static.igem.org/mediawiki/2015/6/6e/NTU-Top-NTU_icon2.png";
 +
}, function () {
 +
this.src = "https://static.igem.org/mediawiki/2015/1/14/NTU-Top-NTU_icon1.png";
 +
});
 +
});
 +
 
 +
</script>
 +
 
 +
<meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
 +
<title>NTU-LIHPAO-Taiwan</title>
 +
<style type="text/css">
 +
 
 +
/*-------------------------------------------*/
 +
/*--------------Wiki Page Reset--------------*/
 +
/*-------------------------------------------*/
 +
 
 +
#contentSub, #contentcontainer, #footer-box, #sitesub, #catlinks, #search-controls, #p-logo, .h3, .printfooter, .firstHeading, .visualClear {
 +
display: none;
 +
}
 +
 
 +
#globalWrapper, #content {
 +
width: 100%;
 +
height: 100%;
 +
border: 0px;
 +
background-color: transparent;
 +
margin: 0px;
 +
padding: 0px;
 +
}
 +
 
 +
html, body, .wrapper {
 +
width: 100%;
 +
height: 100%;
 +
background-color: transparent;
 +
}
 +
 
 +
/*-------------------------------------------*/
 +
/*-------------------Body--------------------*/
 +
/*-------------------------------------------*/
 +
 
 +
body {
 +
background-color: #FFF;
 +
}
 +
body,td,th {
 +
font-size: 14px;
 +
font-family: Calibri, "Arial Narrow", "Agency FB", "Raavi";
 +
}
 +
 
 +
#Wrapper {
 +
margin-right: auto;
 +
margin-left: auto;
 +
background-color: #FFF;
 +
margin-top: 0px;
 +
margin-bottom: 0px;
 +
width: 90%;
 +
height: auto;
 +
top: 0px;
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left: 5%;
 +
right: 5%;
 +
position: absolute;
 +
bottom: 0px;
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padding-top: 0px;
 +
padding-bottom: 0px;
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z-index: 0;
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}
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 +
#Wrapper_Left {
 +
margin-right: auto;
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margin-left: auto;
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background-color: #F0F0F0;
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margin-top: 0px;
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margin-bottom: 0px;
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width: 5%;
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height: 100%;
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top: 0px;
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left: 0%;
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right: auto;
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position: fixed;
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bottom: 0px;
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padding-top: 0px;
 +
padding-bottom: 0px;
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z-index: 0;
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}
 +
 
 +
#Wrapper_Right {
 +
margin-right: auto;
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margin-left: auto;
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background-color: #F0F0F0;
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margin-top: 0px;
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margin-bottom: 0px;
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width: 5%;
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height: 100%;
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top: 0px;
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left: auto;
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right: 0%;
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position: fixed;
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bottom: 0px;
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padding-top: 0px;
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padding-bottom: 0px;
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z-index: 0;
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}
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 +
#Wrapper_TopPic {
 +
margin-right: auto;
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margin-left: auto;
 +
background-color: #FFF;
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margin-top: 0px;
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margin-bottom: 0px;
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width: 100%;
 +
height: 58px;
 +
top: 0px;
 +
left: 0px;
 +
right: 0px;
 +
position: fixed;
 +
bottom: 0px;
 +
padding-top: 0px;
 +
padding-bottom: 0px;
 +
z-index: 9998;
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border-bottom-style: solid;
 +
border-bottom-color: #fe5838;
 +
border-bottom-width: 2px;
 +
z-index: 9998;
 +
background-repeat: no-repeat;
 +
}
 +
 
 +
#Wrapper_Bottom {
 +
width: 100%;
 +
height: 100px;
 +
bottom: 0px;
 +
top: auto;
 +
background-color: #FFF;
 +
border-top-style: solid;
 +
border-top-color: #079235;
 +
border-top-width: 3px;
 +
margin-right: auto;
 +
margin-left: auto;
 +
margin-top: 0px;
 +
margin-bottom: 0px;
 +
z-index: 9998;
 +
position: absolute;
 +
}
 +
 
 +
 
 +
 
 +
/*-------------------------------------------*/
 +
/*-----------------Top icons-----------------*/
 +
/*-------------------------------------------*/
 +
#Facebook_icon_pic {
 +
height: 30px;
 +
width: 30px;
 +
position: absolute;
 +
left: auto;
 +
top: 23px;
 +
right: 5.5%;
 +
bottom: auto;
 +
z-index: 9999;
 +
}
 +
 
 +
#iGEM_icon_pic {
 +
height: 30px;
 +
width: 38px;
 +
position: absolute;
 +
left: auto;
 +
top: 23px;
 +
right: 1%;
 +
bottom: auto;
 +
z-index: 9999;
 +
}
 +
 
 +
#NTU_icon_pic {
 +
height: 30px;
 +
width: 69px;
 +
position: absolute;
 +
left: auto;
 +
top: 23px;
 +
right: 9%;
 +
bottom: auto;
 +
z-index: 9999;
 +
}
 +
 
 +
#NTUXLIHPAO_icon {
 +
height: 40px;
 +
width: 200px;
 +
position: absolute;
 +
left: 3%;
 +
top: 18px;
 +
right: auto;
 +
bottom: auto;
 +
z-index: 9999;
 +
}
 +
 
 +
 
 +
 
 +
/*-------------------------------------------*/
 +
/*-----------------Slide Menu----------------*/
 +
/*-------------------------------------------*/
 +
.Slidemenu {
 +
z-index: 9999;
 +
position: absolute;
 +
top: 32px;
 +
bottom: 0px;
 +
left: 51%;
 +
right: 15%;
 +
list-style:none;
 +
margin:0;
 +
padding:0;
 +
position: absolute;
 +
margin-left: -350px;
 +
/*background:rgba(100%,100%,100%,0); 主選單色系選擇*/
 +
}
 +
 
 +
.Slidemenu ul {
 +
*zoom:1;
 +
list-style:none;
 +
margin:0;
 +
padding:0;
 +
/*background:rgba(100%,100%,100%,0); 主選單色系選擇*/
 +
}
 +
 
 +
.Slidemenu ul:before,.Slidemenu ul:after {
 +
content:"";
 +
display:table;
 +
}
 +
 
 +
.Slidemenu ul:after {
 +
clear:both;
 +
}
 +
 
 +
.Slidemenu a {
 +
text-decoration:none;
 +
display:block;
 +
padding:4px 4px;
 +
line-height:1em;
 +
color:#000;
 +
text-align: center;
 +
vertical-align: middle;
 +
height: auto;
 +
width: auto;
 +
font-family: "Agency FB";
 +
font-size: 1em;
 +
}
 +
 
 +
.Slidemenu a:hover {
 +
text-decoration:none;
 +
background:rgba(0,0,0,0.03);
 +
text-align: center;
 +
vertical-align: middle;
 +
}
 +
 
 +
.Slidemenu li ul {
 +
position:absolute;
 +
left:0;
 +
top:26px;
 +
z-index:1;
 +
}
 +
 
 +
.Slidemenu li ul li {
 +
overflow:hidden;
 +
height: 0px;
 +
margin-bottom: 0px;
 +
}
 +
 
 +
.Slidemenu li ul a {
 +
border:none;
 +
-webkit-transition:background 300ms ease-in-out;
 +
-moz-transition:background 300ms ease-in-out;
 +
-o-transition:background 300ms ease-in-out;
 +
transition:background 300ms ease-in-out;
 +
line-height:1.1em;
 +
}
 +
 
 +
.Slidemenu li ul a:hover {
 +
background-color: rgba(240,240,240,1);
 +
}
 +
 
 +
.Slidemenu ul > li {
 +
text-decoration:none;
 +
float: left;
 +
position: relative;
 +
height: 27px; /*--改主要選單高度--*/
 +
}
 +
 
 +
.width_small {
 +
width: 100px; /*--改主要選單寬度--*/
 +
}
 +
 
 +
.Slidemenu ul > li:hover ul.subs {
 +
height: auto;
 +
width: 150px; /*--改拉出的選單寬度--*/
 +
border-left-width: 3px;
 +
border-left-style: solid;
 +
border-left-color: #3300FF;
 +
background:rgba(255,255,255,1); /*--改拉出選單顏色--*/
 +
}
 +
 
 +
.Slidemenu ul > li:hover ul li {
 +
text-decoration:none;
 +
height: 26px; /*--改拉出的選單高度--*/
 +
width: 150px; /*--改拉出的選單寬度--*/
 +
text-align: center;
 +
vertical-align: middle;
 +
-webkit-transition:height 250ms ease-in;
 +
-moz-transition:height 250ms ease-in;
 +
-o-transition:height 250ms ease-in;
 +
transition:height 250ms ease-in;
 +
}
 +
 
 +
#Position_Now {
 +
background:rgba(0,0,0,0.03);
 +
}
 +
 
 +
 
 +
/*-------------------------------------------*/
 +
/*------------------Content------------------*/
 +
/*-------------------------------------------*/
 +
 
 +
#Content * {
 +
list-style: none;
 +
}
 +
 
 +
#Content_Container {
 +
position: fixed;
 +
width: 17.8%;
 +
height: 100%;
 +
left: 5.2%;
 +
right: auto;
 +
background: #f7fbff;
 +
z-index: 5;
 +
}
 +
 
 +
#Content {
 +
position: absolute;
 +
top: 60px;
 +
width: 100%;
 +
height: auto;
 +
padding: 0;
 +
margin: 0;
 +
transition: 0.5s;
 +
font-size: 0.8rem;
 +
font-family: Calibri;
 +
}
 +
 
 +
#Content-title {
 +
position: absolute;
 +
width: 100%;
 +
top: 0.5rem;
 +
font-size: 1.5rem;
 +
text-align: center;
 +
}
 +
 
 +
#Content ul {
 +
margin: 0.5rem 0rem 0.5rem;
 +
}
 +
 
 +
.main-Content {
 +
position: absolute;
 +
top: 5rem;
 +
left: 10%;
 +
width: 90%;
 +
}
 +
 
 +
.main-Content #title {
 +
color: #ABCDEF;
 +
}
 +
 
 +
.main-Content > li {
 +
cursor: pointer;
 +
color: #369CF5;
 +
font-size: 25px;
 +
padding-top: 5px;
 +
padding-bottom: 5px;
 +
line-height: 30px;
 +
}
 +
 
 +
.sub-Content {
 +
font-size: 18px;
 +
overflow-y: auto;
 +
transition: 0.5s;
 +
width: 85%;
 +
left: 15%;
 +
position: relative;
 +
}
 +
 
 +
.sub-Content > li {
 +
padding-top: 10px;
 +
padding-bottom: 10px;
 +
}
 +
 
 +
.sub-Content > li a{
 +
display: block;
 +
color: #0791DB;
 +
text-decoration: none;
 +
transition: 0.5s;
 +
}
 +
 
 +
.sub-Content > li a:hover {
 +
opacity: 0.5;
 +
}
 +
 
 +
#Healthin_Logo_Content {
 +
width: 100%;
 +
height: auto;
 +
}
 +
 
 +
#Healthin_Logo {
 +
top: 55px;
 +
padding-left: 3%;
 +
padding-right: 3%;
 +
position: absolute;
 +
width: 94%;
 +
height: 94%;
 +
}
 +
 
 +
 
 +
 
 +
/*-------------------------------------------*/
 +
/*---------------Introduction----------------*/
 +
/*-------------------------------------------*/
 +
 
 +
.Container_Bottom1 {
 +
height: 70px;
 +
width: 100%;
 +
}
 +
 
 +
.Container_Bottom2 {
 +
height: 70px;
 +
width: 100%;
 +
padding-top: 10px;
 +
border-top-style: solid;
 +
border-top-color: #079235;
 +
border-top-width: 3px;
 +
}
 +
 
 +
.Intro_Picture {
 +
width: 100%;
 +
height: auto;
 +
background-color: #FFF;
 +
position: absolute;
 +
}
 +
 
 +
#NTUschool_logo {
 +
background-color: #FFF;
 +
padding-left: 9.6%;
 +
padding-right: 60.4%;
 +
position: absolute;
 +
width: 30%;
 +
height: 100%;
 +
}
 +
 
 +
#LIHPAO_logo {
 +
background-color: #FFF;
 +
padding-left: 66.4%;
 +
padding-right: 9.6%;
 +
position: absolute;
 +
width: 24%;
 +
height: 100%;
 +
}
 +
 
 +
#NTUBST_logo {
 +
background-color: #FFF;
 +
padding-left: 49.2%;
 +
padding-right: 43.2%;
 +
position: absolute;
 +
width: 7.6%;
 +
height: 100%;
 +
}
 +
 
 +
.Text_Sponsor {
 +
color: #767676;
 +
font-size: 15px;
 +
font-family: Calibri;
 +
text-align: center;
 +
line-height: 20px;
 +
}
 +
 
 +
 
 +
/*-------------------------------------------*/
 +
/*---------------Article Picture-------------*/
 +
/*-------------------------------------------*/
 +
 
 +
.Container_Article_Picture {
 +
height: 480px;
 +
width: 100%;
 +
padding-top: 25px;
 +
padding-bottom: 25px;
 +
}
 +
 
 +
.Article_Picture {
 +
width: 480px;
 +
height: auto;
 +
left: 50%;
 +
right: auto;
 +
background-color: #FFF;
 +
margin: 0 0 0 -240px;
 +
position: absolute;
 +
}
 +
 
 +
.Article_PictureText {
 +
width: 430px;
 +
height: auto;
 +
padding-left: 25px;
 +
padding-right: 25px;
 +
border-top-width: 2px;
 +
border-top-style: dashed;
 +
border-top-color: #fe5838;
 +
}
 +
 
 +
.Text_Picture {
 +
font-size: 18px;
 +
font-family: Calibri;
 +
text-align: justify;
 +
line-height: 26px;
 +
color: #08923a;
 +
}
 +
 
 +
 
 +
/*-------------------------------------------*/
 +
/*-----------------Articles------------------*/
 +
/*-------------------------------------------*/
 +
 
 +
#Articles {
 +
width: 100%;
 +
height: auto;
 +
top: -10px;
 +
position: absolute;
 +
background-color: #FFF;
 +
z-index: 1;
 +
color: #000;
 +
}
 +
 
 +
.ContentBox {
 +
width: 76%;
 +
height: auto;
 +
left: 22%;
 +
right: 2%;
 +
position: absolute;
 +
background-color: #FFF;
 +
}
 +
 
 +
.Text1 {
 +
font-size: 28px;
 +
font-family: Calibri;
 +
left: 20px;
 +
right: 20px;
 +
padding-top: 80px;
 +
padding-right: 20px;
 +
padding-bottom: 10px;
 +
padding-left: 20px;
 +
border-bottom-width: 2px;
 +
border-bottom-style: dashed;
 +
border-bottom-color: #fe5838;
 +
color: #c00000;
 +
}
 +
 
 +
.Text2 {
 +
font-size: 24px;
 +
font-family: Calibri;
 +
padding-top: 30px;
 +
padding-right: 50px;
 +
padding-bottom: 10px;
 +
padding-left: 50px;
 +
color: #00b050;
 +
}
 +
 
 +
.Text3 {
 +
font-size: 20px;
 +
font-family: Calibri;
 +
text-align: justify;
 +
padding-top: 10px;
 +
padding-right: 80px;
 +
padding-bottom: 10px;
 +
padding-left: 80px;
 +
line-height: 26px;
 +
}
 +
 
 +
.Text_TitleUnderline {
 +
font-size: 22px;
 +
font-family: Calibri;
 +
text-align: justify;
 +
padding-top: 10px;
 +
padding-bottom: 0px;
 +
line-height: 26px;
 +
color: #0070c0;
 +
text-decoration: underline;
 +
}
 +
 
 +
.Text_italic {
 +
font-style: italic;
 +
}
 +
 
 +
ol.part1 {
 +
list-style-type: none;
 +
margin-left: 0px;
 +
}
 +
 
 +
ol.part2 {
 +
list-style-type: decimal;
 +
margin-left: 0px;
 +
padding-left: 50px;
 +
}
 +
 
 +
ol.part2 li {
 +
padding-top: 3px;
 +
padding-bottom: 3px;
 +
}
 +
 
 +
ol.part3 {
 +
list-style-type: lower-alpha;
 +
}
 +
 
 +
 
 +
/*-------------------------------------------*/
 +
/*-------------------Media-------------------*/
 +
/*-------------------------------------------*/
 +
 
 +
@media screen and (min-width: 0px) and (max-width: 1200px) {
 +
 
 +
#NTUXLIHPAO_icon {
 +
height: 40px;
 +
width: 200px;
 +
position: absolute;
 +
left: 1%;
 +
top: 18px;
 +
right: auto;
 +
bottom: auto;
 +
z-index: 9999;
 +
}
 +
 
 +
 
 +
#width_small {
 +
width: 95px; /*--改主要選單寬度--*/
 +
}
 +
 
 +
.Slidemenu {
 +
z-index: 9999;
 +
position: absolute;
 +
top: 32px;
 +
bottom: 0px;
 +
left: 49%;
 +
right: auto;
 +
list-style:none;
 +
margin:0;
 +
padding:0;
 +
position: absolute;
 +
margin-left: -320px;
 +
/*background:rgba(100%,100%,100%,0); 主選單色系選擇*/
 +
}
 +
}
 +
 
 +
@media screen and (min-width: 901px) and (max-width: 1050px) {
 +
 
 +
.Container_Bottom2 {
 +
height: 60px;
 +
width: 100%;
 +
padding-top: 10px;
 +
border-top-style: solid;
 +
border-top-color: #079235;
 +
border-top-width: 3px;
 +
}
 +
}
 +
 
 +
@media screen and (min-width: 0px) and (max-width: 900px) {
 +
 
 +
.Container_Bottom2 {
 +
height: 50px;
 +
width: 100%;
 +
padding-top: 10px;
 +
border-top-style: solid;
 +
border-top-color: #079235;
 +
border-top-width: 3px;
 +
}
 +
}
 +
 
 +
 
 +
</style>
 +
</head>
 +
 
 +
 
 +
<!---------------------------------------->
 +
<!---------------------------------------->
 +
<!------------------BODY------------------>
 +
<!---------------------------------------->
 +
<!---------------------------------------->
 +
 
 +
<body>
 +
 
 +
<div id="Wrapper_Left"></div>
 +
<div id="Wrapper_Right"></div>
 +
 
 +
<div id="Wrapper">
 +
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<div class="Text1">Modeling</div>
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<div class="Text2" id="First1">Introduction</div>
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Noticing the problem of obesity growing in Taiwan, our team NTU-LIHPAO-Taiwan make efforts to improve a designed probiotic for oral peptide drug — “Healthin”. For preventing the side effects from commercial weight loss pills, as in our project design, the product CPP-PYY complex is produced by genetically modified <i>Lactobacillus casei</i>, which is orally ingested. TAT helps to penetrate through the villi, and the released PYY then binds to hypothalamus for appetite suppression.
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<div class="Text3">
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In the Modeling part, we tried to <b>simulate the pathways of our designed probiotic <i>L. casei</i> and secreted CPP-PYY complex inside human body</b>, from oral ingestion to final PYY releasing, respectively. The ultimate goal is to <b>build the general formula, and to find out the suitable and optimal dose for Healthin</b>, which hopefully exerts the beneficial and harmless effect for appetite suppression.
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<div class="Text3">
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In general, after taking Healthin, some <i>L. casei</i> pass through stomach and reach human intestine. Within the transient colonization, these modified <i>L. casei</i> produce CPP-PYY complex, and with the help of TAT, the complexes penetrate through the small intestine epithelial cells into circulation system. The linker between the complex is cut by thrombin in the blood, thus releasing free PYY for circulation, which binds to Y2 receptor in the hypothalamus for controlling satiety feeling. Moreover, the suicide device and bacteria survival were also considered in the simulation for safety concern. Combining data obtained from experimental results and several literatures, we applied MATLAB for calculation and simulation. By analyzing the pathways of <i>L. casei</i> inside human body step by step, the ultimate dose could be determined from the general formula.
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<p>Mathematical models and computer simulations provide a great way to describe the function and operation of BioBrick Parts and Devices. Synthetic Biology is an engineering discipline, and part of engineering is simulation and modeling to determine the behavior of your design before you build it. Designing and simulating can be iterated many times in a computer before moving to the lab. This award is for teams who build a model of their system and use it to inform system design or simulate expected behavior in conjunction with experiments in the wetlab.</p>
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<div class="Text2" id="First2">Pathways</div>
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The pathways of the novel oral peptide drug Healthin consist of 5 parts, from intake through peptide release inside human body :
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<ol class="part2">
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        <li>Bacteria distribution</li>
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        <li>CPP-PYY penetration efficiency</li>
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        <li>Absorption into bloodstream</li>
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        <li>Thrombin cleavage efficiency</li>
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        <li>Healthin drug effect</li>
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<div class="Text3">
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By utilizing MATLAB, we built a model from these pathways to construct the general formula for determining the dose response.
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</div>
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<div class="Text3">
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<b>—></b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="https://2015.igem.org/Team:NTU-LIHPAO-Taiwan/Modeling/Pathways"><b>[Click on here to see our Simulation Strategy and Results]</b></a>
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<div class="Text3">
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<b>—></b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="https://2015.igem.org/Team:NTU-LIHPAO-Taiwan/Modeling/Conclusion"><b>[Click on here for Conclusion and Application]</b></a>
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<div class="Article_PictureText"><div class="Text_Picture">[Fig.2-1] Pathway of Healthin</div></div>
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Here are a few examples from previous teams:
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<li><a href="https://2014.igem.org/Team:ETH_Zurich/modeling/overview">ETH Zurich 2014</a></li>
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<div id="LIHPAO_logo"><a href="http://www.llsc.com.tw/"><img src="https://static.igem.org/mediawiki/2015/d/d4/LIHPAO_logo.png" style="max-width: 100%; max-height: 70px"/></a></div>
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<li><a href="https://2014.igem.org/Team:Waterloo/Math_Book">Waterloo 2014</a></li>
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Maintained by the iGEM team NTU-LIHPAO-Taiwan&nbsp;&nbsp;&nbsp;&nbsp;©2015 NTU-LIHPAO-Taiwan
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Latest revision as of 13:15, 18 September 2015

NTU-LIHPAO-Taiwan

Modeling
Introduction
Noticing the problem of obesity growing in Taiwan, our team NTU-LIHPAO-Taiwan make efforts to improve a designed probiotic for oral peptide drug — “Healthin”. For preventing the side effects from commercial weight loss pills, as in our project design, the product CPP-PYY complex is produced by genetically modified Lactobacillus casei, which is orally ingested. TAT helps to penetrate through the villi, and the released PYY then binds to hypothalamus for appetite suppression.
In the Modeling part, we tried to simulate the pathways of our designed probiotic L. casei and secreted CPP-PYY complex inside human body, from oral ingestion to final PYY releasing, respectively. The ultimate goal is to build the general formula, and to find out the suitable and optimal dose for Healthin, which hopefully exerts the beneficial and harmless effect for appetite suppression.
In general, after taking Healthin, some L. casei pass through stomach and reach human intestine. Within the transient colonization, these modified L. casei produce CPP-PYY complex, and with the help of TAT, the complexes penetrate through the small intestine epithelial cells into circulation system. The linker between the complex is cut by thrombin in the blood, thus releasing free PYY for circulation, which binds to Y2 receptor in the hypothalamus for controlling satiety feeling. Moreover, the suicide device and bacteria survival were also considered in the simulation for safety concern. Combining data obtained from experimental results and several literatures, we applied MATLAB for calculation and simulation. By analyzing the pathways of L. casei inside human body step by step, the ultimate dose could be determined from the general formula.
Pathways
The pathways of the novel oral peptide drug Healthin consist of 5 parts, from intake through peptide release inside human body :
  1. Bacteria distribution
  2. CPP-PYY penetration efficiency
  3. Absorption into bloodstream
  4. Thrombin cleavage efficiency
  5. Healthin drug effect
By utilizing MATLAB, we built a model from these pathways to construct the general formula for determining the dose response.
—>     [Click on here to see our Simulation Strategy and Results]
—>     [Click on here for Conclusion and Application]
[Fig.2-1] Pathway of Healthin
Maintained by the iGEM team NTU-LIHPAO-Taiwan    ©2015 NTU-LIHPAO-Taiwan