Difference between revisions of "Team:Czech Republic/Safety"

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<h2>Safety in iGEM</h2>
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<p>Please visit <a href="https://2015.igem.org/Safety">the main Safety page</a> to find this year's safety requirements & deadlines, and to learn about safe & responsible research in iGEM.</p>
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= Safe Project Design =
  
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<p>On this page of your wiki, you should write about how you are addressing any safety issues in your project. The wiki is a place where you can <strong>go beyond the questions on the safety forms</strong>, and write about whatever safety topics are most interesting in your project. (You do not need to copy your safety forms onto this wiki page.)</p>
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We discussed the safety issues of our technology throughout the whole duration of the project since we were aware of working with modified ''S. cerevisiae'' with the vision to use them in a clinical setting. ''S. cerevisiae'' belongs to the Risk Group 1, which describes the organism as not causing a disease in healthy humans. The fact that our end consumers are cancer patients who are more often immunocompromised than not could raise a significant concern. However, the design of our technology devotes it to be used by trained laboratory clinicians who receive the patients’ blood, perform the test themselves, and deliver only the results to the individual being screened.
  
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The opinions on our technology have been very positive and encouraging. The lay person is usually very curious and thrilled once he or she grasps the concept behind our technology. A positive opinion can be seen even more clearly from the [[Team:Czech_Republic/Practices/Interview | interview]] with Dr. Pitule and Dr. Ostasov from the Laboratory of Tumor Biology. Discussions with professionals and experts in the tumor diagnosis field indicate our product to be cheaper and easier to operate than most of the current diagnostic approaches. Also, it presents a solid competition in terms of its sensitivity and specificity compared to the current diagnostic tests. Finally, it brings a new dimension to the field providing the ability to test for several markers at once.
  
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<h4>Safe Project Design</h4>
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Discard of the used test would not be different from discarding GMO or biological material in a laboratory.
  
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<p>Does your project include any safety features? Have you made certain decisions about the design to reduce risks? Write about them here! For example:</p>
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= Safe Lab Work =
  
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With most of our team having extensive wet laboratory experience, it was quite effortless to follow standard lab safety practices. Furthermore, our laboratory is monitored by the Ministry of the Environment of the Czech Republic and complies with all of its regulations for a GMO laboratory. This was also evidenced by the recent visit of an inspection team from the Ministry, which was carried out without any complications.
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<li>Choosing a non-pathogenic chassis</li>
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<li>Choosing parts that will not harm humans / animals / plants</li>
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<li>Substituting safer materials for dangerous materials in a proof-of-concept experiment</li>
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<li>Including an "induced lethality" or "kill-switch" device</li>
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<h4>Safe Lab Work</h4>
 
  
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<p>What safety procedures do you use every day in the lab? Did you perform any unusual experiments, or face any unusual safety issues? Write about them here!</p>
 
  
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<h4>Safe Shipment</h4>
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{{:Team:Czech_Republic/Template:Bottom}}
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<p>Did you face any safety problems in sending your DNA parts to the Registry? How did you solve those problems?</p>
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Latest revision as of 13:47, 18 September 2015

Safety

Safe Project Design

We discussed the safety issues of our technology throughout the whole duration of the project since we were aware of working with modified S. cerevisiae with the vision to use them in a clinical setting. S. cerevisiae belongs to the Risk Group 1, which describes the organism as not causing a disease in healthy humans. The fact that our end consumers are cancer patients who are more often immunocompromised than not could raise a significant concern. However, the design of our technology devotes it to be used by trained laboratory clinicians who receive the patients’ blood, perform the test themselves, and deliver only the results to the individual being screened.

The opinions on our technology have been very positive and encouraging. The lay person is usually very curious and thrilled once he or she grasps the concept behind our technology. A positive opinion can be seen even more clearly from the interview with Dr. Pitule and Dr. Ostasov from the Laboratory of Tumor Biology. Discussions with professionals and experts in the tumor diagnosis field indicate our product to be cheaper and easier to operate than most of the current diagnostic approaches. Also, it presents a solid competition in terms of its sensitivity and specificity compared to the current diagnostic tests. Finally, it brings a new dimension to the field providing the ability to test for several markers at once.

Discard of the used test would not be different from discarding GMO or biological material in a laboratory.

Safe Lab Work

With most of our team having extensive wet laboratory experience, it was quite effortless to follow standard lab safety practices. Furthermore, our laboratory is monitored by the Ministry of the Environment of the Czech Republic and complies with all of its regulations for a GMO laboratory. This was also evidenced by the recent visit of an inspection team from the Ministry, which was carried out without any complications.