Difference between revisions of "Team:NJU-China/Description"
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In this project, we constructed a plasmid expressing the neuron-targeting peptide RVG and employed HEK293 cells as donor cells to acquire exosomes expressing RVG on the surface. We also proposed a strategy of using RVG exosomes to encapsulate MOR siRNA and specifically deliver them to the brain. As a consequence, RVG exosome-delivered MOR siRNA can reversibly block or attenuate the effects of opioids, thereby functions as therapeutics for the prevention of relapse to opioid dependence following detoxification. | In this project, we constructed a plasmid expressing the neuron-targeting peptide RVG and employed HEK293 cells as donor cells to acquire exosomes expressing RVG on the surface. We also proposed a strategy of using RVG exosomes to encapsulate MOR siRNA and specifically deliver them to the brain. As a consequence, RVG exosome-delivered MOR siRNA can reversibly block or attenuate the effects of opioids, thereby functions as therapeutics for the prevention of relapse to opioid dependence following detoxification. | ||
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Revision as of 14:59, 18 September 2015
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