Difference between revisions of "Team:Valencia UPV/Practices"

 
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<h2 style="font-weight:bold">Polices and practices</h2>
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<h2>Policy and practices</h2>
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<p> How AladDNA affects the world, and how the world affects AladDNA</p>
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<p> How AladDNA affects the world, and how the world affects AladDNA</p>
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<li><a href="#scroll1" class="button">Overview</a></li>
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<li><a href="#main" id="button01" class="button">Minecraft</a></li>
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<li><a href="https://2015.igem.org/Team:Valencia_UPV/Practices/Minecraft" class="button">SynBiocraft</a></li>
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<li><a href="#main" id="button02" class="button">Safety</a></li>
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<li><a href="https://2015.igem.org/Team:Valencia_UPV/Practices/Safety" class="button">Safety</a></li>
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<li><a href="#main" id="button03" class="button">Collaboration</a></li>
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<li><a href="https://2015.igem.org/Team:Valencia_UPV/Collaborations" class="button">Collaboration</a></li>
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<h2>Overview<br />
 
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<p>From the real to the virtual world</p>
 
  
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<p>Valencia-UPV team strongly believes that Synthetic Biology has the potential to change our world for good. To fulfil this potential, we as technologists should avoid repeating earlier technology mistakes, and very especially we should avoid developing a technology that ends up benefiting only a few.</p>
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<p>In line with this, the Philosophy guiding the Valencia-UPV iGEM team considers Synthetic Biology as a technology that should be employed to the benefit of the Society in its broadest sense, and should be mainly directed to benefit those that need it most. In other words, we at the UPV-Team envision a <b>Synthetic for the People.</b> </p>
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<h3 style="text-align:left">Sub section 1<br />
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<p>We also believe that the most efficient strategy to reach this aim is by narrowing the gap between the technology and the society. For this we need to increase the understanding of the technology, simplify procedures, develop open-source tools and instruments, and popularize its use. In other words, we envision a <b>Synthetic Biology</b> not only for the people, but also <b>by the People.</b></p>
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<p>Popularization of Synthetic Biology should not be at odds with safety. Broad use of the technology should walk along with a deep understanding of the risks/benefits balance of each project and should be always accompanied by the development and fulfilment of strict safety measures that ensure that each technical development brought to practice is <b>harmless</b> for the people and the environment. </p>
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<p>These are the three principles that inspired our Policy and Practices activities and indeed our project as a whole: Synthetic Biology for the people, by the people, and harmless by all means. </p>
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<h3 style="text-align:left">Philosophy meets Practice<br />
 
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<p>Hello world</p>
 
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<h2>Safety<br />
 
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<p>The safety of a project is always a very important part to take into account, especially if the project involves living organisms*. For that reason in our project we have taken all the safety precautions while working in the lab. Things like working on sterile conditions, using gloves or disposing waste in the corresponding container were the bases of our diary work lab, obviously.
 
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But with our project, AladDNA, we thought to make a step further and think about the safety of our circuit chassis, our genetically modify plant. We had to make a real effort in this due to that the special characteristics that our plant has:
 
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# Drugs production. (enlace)
 
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# Circuit activation by light at different wavelength.
 
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# Functionality of both things named before in a germinated seed.
 
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We want AladDNA to be a safe project for the environment and for people all over the world. (esto centrado y en cursiva)
 
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To afford all the questions that appeared during the realization of the project we decided to talk to some experts in the area. Also we make some research in the field of legality of transgenic modify organisms and the regulation of the plant growing and production. To see in more detail click the buttons bellow.
 
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<h3 style="text-align:left">Expertise<br />
 
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<p>Having other people opinion is always a good thing so we talk with two different experts, Carmelo López that guides us in the general legislation of a GMO and Jose Miguel Mullet…
 
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First we talk to Carmelo López del Rincón, titular professor of the Biotechnology Department at the UPV. He imparts courses related to plants production and genetically modified food as well as courses of the GMO legislation.
 
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He showed us the general legislation that a transgenic plant has to accomplish in Spain, Europe and internationally to be accepted and commercialized.
 
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There are three levels of legislation that our transgenic plant will have to accomplish.  The first one is the estate level, the second one is the EU although both are closely related and finally the international level that is ruled by the Cartagena treaty (enlace al doc).
 
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Also we talked about possible measures that will improve and facilitate the introduction into the environment of our plant. The most highlight option was to locate our circuit into the chloroplasts. Chloroplasts will avoid that the production go out the cell and so secrete it into the environment. But main problems were found, for example the insertion of the DNA will have to be in a 100% effectiveness. Other issue that we found is that in seeds the chloroplasts are immature because they do not receive light and so they will not be working normally.
 
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Finally we discard this option.</p>
 
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<h3 style="text-align:left">Legal aspects<br />
 
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<p>In this submenu we are going to amplify the information obtained by the interview whi carmelo. So, we are going to talk with more detail about the specific laws in spain, europe and internatinally. (gift de obama)
 
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Something to point out is that after researching and reading some documents we can observed that the main idea is the same. The law wants to protect people and the enviroment an avoid any incident cause by a GMO. We as a group human beings and citiziens, want that anyone or anything can be injure so for that we decided invest time to know how to avoid any kind of problem that may or may not occur with our genetically modify plant.
 
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Lets begin with the Spanish law about GMO. It is controlled by the Ministerio de Agricultura, Alimentación y Medio Ambiente. It is in charge of controlling the commercialization and voluntary liberation of the GMO in the environment in case that this organism produce medicines for human and veterinary use, as it is in our case (Chapter2, article3 from law 9/2003, de 25 April). Also the ministry collaborate and exchange information with the European Union that have an important role making the decisions.
 
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One thing to keep in mind is that our project will be evaluated step by step so is very important to fill correctly all the attaches needed. This are the general data asked in the 
 
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The competency of the EU i
 
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The protocol of Cartagena is…
 
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(Esto falta acabarlo, no me quedann neuronas despiertas)
 
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Finally is necessary to point out that every modify organism is studied and treat as unique and need an especial treatment
 
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<h3 style="text-align:left">Solutions to have a safety AladDNA<br />
 
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<p>After researching about all the conditions to handle and distribute our plant finally we come up with some conclusions to make AlaDNA a very very safety project.
 
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First of all, our seedlings will germinate into a recipient, “the magic lamp” (enlace a magic lamp), a handling device that has been designed exclusively to put up with the growing seeds. The lamp will give to the seedlings the right light pulses controlling the optimal conditions to make a regular production of the drugs.
 
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It is made taking into account all the details for instance the electronic part is isolated form the growing section. The system to close the device is hermetic so the seeds can go out until their need to be consumed. More info here.
 
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(foto de la lamapara por la mitad y con un germinado)
 
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Furthermore, we thought about the idea of growing our plant in a greenhouse to produce more drugs doses to supply a small village in a remote place in the world, for instance. This is also possible! With the respective bureaucracy and a close and hermetic greenhouse authorized for that kind of activity (quiza alguna palabra mas tecnica), it just will be necessary the seeds, the leds, a bit of water and… magic! The production made by a live organism avoids the big expenses on money that will suppose create in a difficult access place an industry to produce unlimited drugs.
 
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The information is reduced to its minimal expression and the infrastructure is just a small seed!
 
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If our chassis stay inside a controlled device and there is no intencionally liberation into the environment, there will be no problem at all. But, what happened if someone accidentally drop a seed into the wild… DISASTER!
 
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No, it is just a joke! AlaDNA will pass for sure the controls of a transgenic plant. Moreover we think in a method of regulation in case that something happen. We can make our seed WHAT? (necesito un metodo que 1.evite que la semilla germine y por tanto que no se produzcca ningun medicamento o 2.que apenas germine se muera)(creo que acabaría de rematar toda la idea del safety)
 
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The especial “what ever” regulator allow AladDNA to be also safe in case accidentally liberation.
 
  
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Ok, now after reading all this restrictions that we make to our plant you might think, why all this restrictions to their plant? Well that is a good question.
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<p>Early in our brainstorm meetings we were looking for a project that helped to improve the life conditions of the people, right now and in the near future. ….<b>and UPVteam created AladDNA.</b> Our eukaryotic decoder is first and above all projected as a portable factory of medicines; we engaged experts in our community (Farmamundi) to sort out which were the most needed medicines that could be produced with our system. See more on this in <a href="https://2015.igem.org/Team:Valencia_UPV/Collaborations">collaborations.</a></p>
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AladDNA was thought as a perfect way to reduce to the minimum all the information needed for the production of drugs or any other substance but with a social propose: provide an easy, self-made, and cheap way to get closer the products need in specific situations.
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Our aim is that no matter where you are, in a lost mountain, in a catastrophic area, in the middle of the desert or in the middle of the city in rush hour or even far away in the space, you can cover in a short period of time your necessity.
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The characteristic that AladDNA is for all users leads to the following point. As our project is think as a biofarmaceutical resourece, pointing out that the circuit can have any final biological production, we will need to study in a future al the drugs produced. This is even more complicated, it is easy to explain, just watch the graphic and the numbers in it… Xmillion dollars!?
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<p>Our team also wanted to bring a new social dimension to our project, that is, the ability to explain it (and explain Synthetic Biology) in a completely unusual language. A language employed by more and more people in the world, especially by young people, those that we hope will be not only users but also developers of our technology: the language of the Computer Games...<b>and UPVteam created SynBioCraft.</b> Our Minecraft Mod is a virtual tool for building Synthetic Biology projects.  SynBioCraft has allowed us to interact with many young people using their same language. SynBioCraft is a virtual SynBio lab with the doors wide open to everyone with curiosity. See more on this in <a href="https://2015.igem.org/Team:Valencia_UPV/Practices/Minecraft">SynBioCraft.</a></p>
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(grafica con la inversion necesaria) (otra si encuentro con los tiempos de espera para legalizar un rpoducto)
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<p>Finally, we investigated the risks associated to our AladDNA design and elaborated a set of technical recommendations aimed to minimize these risks, with special attention to detect and turn innocuous any unintended release of AladDNA components into the environment... <b>and UPVteam saw that it was safe.</b> Our risk analysis concluded that the risks associated with environmental release are low, and could be brought virtually to zero with the implementation of additional biotechnology measures. See more on <a href="https://2015.igem.org/Team:Valencia_UPV/Practices/Safety">Safety</a>
 
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<li><a href="https://2015.igem.org/Team:Valencia_UPV/Practices/Minecraft" class="button alt">SynBiocraft</a></li>
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<li><a href="https://2015.igem.org/Team:Valencia_UPV/Practices/Safety" class="button alt">Safety</a></li>
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Latest revision as of 17:23, 18 September 2015

Valencia UPV iGEM 2015

Overview

Valencia-UPV team strongly believes that Synthetic Biology has the potential to change our world for good. To fulfil this potential, we as technologists should avoid repeating earlier technology mistakes, and very especially we should avoid developing a technology that ends up benefiting only a few.

In line with this, the Philosophy guiding the Valencia-UPV iGEM team considers Synthetic Biology as a technology that should be employed to the benefit of the Society in its broadest sense, and should be mainly directed to benefit those that need it most. In other words, we at the UPV-Team envision a Synthetic for the People.

We also believe that the most efficient strategy to reach this aim is by narrowing the gap between the technology and the society. For this we need to increase the understanding of the technology, simplify procedures, develop open-source tools and instruments, and popularize its use. In other words, we envision a Synthetic Biology not only for the people, but also by the People.

Popularization of Synthetic Biology should not be at odds with safety. Broad use of the technology should walk along with a deep understanding of the risks/benefits balance of each project and should be always accompanied by the development and fulfilment of strict safety measures that ensure that each technical development brought to practice is harmless for the people and the environment.

These are the three principles that inspired our Policy and Practices activities and indeed our project as a whole: Synthetic Biology for the people, by the people, and harmless by all means.

Philosophy meets Practice

Early in our brainstorm meetings we were looking for a project that helped to improve the life conditions of the people, right now and in the near future. ….and UPVteam created AladDNA. Our eukaryotic decoder is first and above all projected as a portable factory of medicines; we engaged experts in our community (Farmamundi) to sort out which were the most needed medicines that could be produced with our system. See more on this in collaborations.

Our team also wanted to bring a new social dimension to our project, that is, the ability to explain it (and explain Synthetic Biology) in a completely unusual language. A language employed by more and more people in the world, especially by young people, those that we hope will be not only users but also developers of our technology: the language of the Computer Games...and UPVteam created SynBioCraft. Our Minecraft Mod is a virtual tool for building Synthetic Biology projects. SynBioCraft has allowed us to interact with many young people using their same language. SynBioCraft is a virtual SynBio lab with the doors wide open to everyone with curiosity. See more on this in SynBioCraft.

Finally, we investigated the risks associated to our AladDNA design and elaborated a set of technical recommendations aimed to minimize these risks, with special attention to detect and turn innocuous any unintended release of AladDNA components into the environment... and UPVteam saw that it was safe. Our risk analysis concluded that the risks associated with environmental release are low, and could be brought virtually to zero with the implementation of additional biotechnology measures. See more on Safety