|
|
| (3 intermediate revisions by the same user not shown) |
| Line 1: |
Line 1: |
| | {{UNAM-CU}} | | {{UNAM-CU}} |
| | <html> | | <html> |
| − | <h2> Welcome to iGEM 2015! </h2> | + | <h2> IGEM-CU page! </h2> |
| − | <p>Your team has been approved and you are ready to start the iGEM season! </p> | + | <p>Welcome to IGEM-CU page </p> |
| | <h4>Our project: </h4> | | <h4>Our project: </h4> |
| | | | |
| − | <p> The main goal of our project is to modify a bacteria in order to make it capable of sensing the level of glucose in the nearby area, produce a quantity of insuline according to the glucose levels and take that insuline to the outer side. In a right context, the abilities of this (or these) bacteria would allow body cells to take advantage of the glucose overriding hyperglycemia. | + | <p> Can you imagine a device containing a bacterium, to detect glucose throughout the day and in response to it expulse insulin? Imagine the possibilities this could have if implemented, by means of a device such as treatment in type 1 diabetes and some cases of type 2 diabetes? |
| | | | |
| − | <p> In recent years, bacteria modified by means of biotechnology are used as the main system to obtain artificial insuline, which is possible to administrate to people who can't produce insuline by themselves, like people with type 2 diabetes. | + | <p> IGEM-CU is doing everything possible so that the answers to these questions come true! |
| − | One of the main disadvantages of that production system is the constant patient's need for injections with specific dosis. The dosis might change through time due to the patient's diet and metabolism.
| + | |
| | | | |
| − | <p> The correct folding of insulin requires an oxidative environment that allows the formation of two disulfide bonds between the two different polypeptide chains that build the insulin structure as well as a third disulphide bond within a single chain, a reason why it becomes harder for biotechnologists to produce it in large quantities.
| |
| | | | |
| − | <p> Under those circumstances, and because we want to use E. coli to build a circuit, we decided to use the SHuffle strain of E. coli, characterized by its capability to grow having an oxidative cytoplasmic environment, allowing the creation of functional disulphide bonds in many proteins.
| + | <h4>Why? </h4> |
| − | | + | <p> Because:</p> |
| − | <p> Using mathematical modeling, we expect to be able to theorize the interaction between the different factors implicated in our system, such as the glucose levels in blood resulting from a response to the insulin generated by the bacteria.
| + | |
| − | | + | |
| − | <p> In summary, the final result that is expected from our investigation is the possibility to stablish an useful alternative for insuline dependant people, allowing them to maintain more suitable glucose levels, improving their health and quality of life.
| + | |
| − | | + | |
| − | | + | |
| − | <h4>Before you start: </h4> | + | |
| − | <p> Please read the following pages:</p> | + | |
| | <ul> | | <ul> |
| − | <li> <a href="https://2015.igem.org/Requirements">Requirements page </a> </li> | + | <li>In 2014 the global prevalence of diabetes * was estimated to be 9% among adults aged 18+ years. </li> |
| − | <li> <a href="https://2015.igem.org/Wiki_How-To">Wiki Requirements page</a></li> | + | <li>In 2012, an estimated 1.5 million deaths were directly caused by diabetes</li> |
| | + | <li>More than 80% of diabetes deaths occur in low- and middle-income countries</li> |
| | + | <li>And we want to make it better</li> |
| | </ul> | | </ul> |
| | | | |
| − | <div class="highlightBox">
| |
| − | <h4> Styling your wiki </h4>
| |
| − | <p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
| |
| − | <p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
| |
| − | </div>
| |
| | | | |
| − | <h4> Editing your wiki </h4> | + | <h4>How? </h4> |
| − | <p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
| + | <p> Because:</p> |
| − | <p> <a href="https://2015.igem.org/wiki/index.php?title=Team:UNAM-CU&action=edit"> Click here to edit this page! </a></p>
| + | |
| − | <p>See tips on how to edit your wiki on the <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation</a> page.</p>
| + | |
| − | | + | |
| − | | + | |
| − | <h4>Templates </h4>
| + | |
| − | <p> This year we have created templates for teams to use freely. More information on how to use and edit the templates can be found on the
| + | |
| − | <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation </a> page.</p>
| + | |
| − | | + | |
| − | | + | |
| − | <h4>Tips</h4>
| + | |
| − | <p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p> | + | |
| | <ul> | | <ul> |
| − | <li>State your accomplishments! Tell people what you have achieved from the start. </li> | + | <li>By bringing together a group of students of medicine, biology, chemistry, engineering, mathematics and biomedicine.</li> |
| − | <li>Be clear about what you are doing and how you plan to do this.</li> | + | <li>Taking advantage of individual skills and abilities make them within a team</li> |
| − | <li>You have a global audience! Consider the different backgrounds that your users come from.</li> | + | <li>Using tools of molecular biology</li> |
| − | <li>Make sure information is easy to find; nothing should be more than 3 clicks away. </li> | + | <li>Creating an organism that can measure glucose in the medium, in response to it, synthesize insulin and subsequently to eject means.</li> |
| − | <li>Avoid using very small fonts and low contrast colors; information should be easy to read. </li>
| + | <li>Designing a device that is functional, economical and safety for all users</li> |
| − | <li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2015.igem.org/Calendar_of_Events">iGEM 2015 calendar</a> </li> | + | <li>Creating a mathematical model which explains each variable involved in the experiment</li> |
| − | <li>Have lots of fun! </li>
| + | <li>And finally, designate a doctor to monitor them all and ensure that the experiment is safe and functional!</li> |
| − | </ul>
| + | |
| − | | + | |
| − | | + | |
| − | <h4>Inspiration</h4>
| + | |
| − | <p> You can also view other team wikis for inspiration! Here are some examples:</p>
| + | |
| − | <ul>
| + | |
| − | <li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
| + | |
| − | <li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li> | + | |
| − | <li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li> | + | |
| − | <li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
| + | |
| − | <li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
| + | |
| − | <li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
| + | |
| | </ul> | | </ul> |
| − |
| |
| − | <h4> Uploading pictures and files </h4>
| |
| − | <p> You can upload your pictures and files to the iGEM 2015 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
| |
| − | When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
| |
| − |
| |
| − | <a href="https://2015.igem.org/Special:Upload">CLICK HERE TO UPLOAD FILES</a>
| |
| | | | |
| | | | |
| | + | <h3><center>If you have interested, be prepared to read the interesting trip UNAM students had to do to make a project that could help many people around the world</center> </h3> |
| | | | |
| − | </div></div> <!--These are the closing tags for div id="mainContainer" and div id="contentContainer". The corresponding opening tags appear in the template that is {{included}} at the top of this page.-->
| |
| | | | |
| | </html> | | </html> |
IGEM-CU page!
Welcome to IGEM-CU page
Our project:
Can you imagine a device containing a bacterium, to detect glucose throughout the day and in response to it expulse insulin? Imagine the possibilities this could have if implemented, by means of a device such as treatment in type 1 diabetes and some cases of type 2 diabetes?
IGEM-CU is doing everything possible so that the answers to these questions come true!
Why?
Because:
- In 2014 the global prevalence of diabetes * was estimated to be 9% among adults aged 18+ years.
- In 2012, an estimated 1.5 million deaths were directly caused by diabetes
- More than 80% of diabetes deaths occur in low- and middle-income countries
- And we want to make it better
How?
Because:
- By bringing together a group of students of medicine, biology, chemistry, engineering, mathematics and biomedicine.
- Taking advantage of individual skills and abilities make them within a team
- Using tools of molecular biology
- Creating an organism that can measure glucose in the medium, in response to it, synthesize insulin and subsequently to eject means.
- Designing a device that is functional, economical and safety for all users
- Creating a mathematical model which explains each variable involved in the experiment
- And finally, designate a doctor to monitor them all and ensure that the experiment is safe and functional!
If you have interested, be prepared to read the interesting trip UNAM students had to do to make a project that could help many people around the world
