Difference between revisions of "Team:WLC-Milwaukee"

 
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<h2> Welcome to iGEM 2015! </h2>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<h4>Before you start: </h4>
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</head>
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<p> Please read the following pages:</p>
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<body>
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<ul>
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<li>  <a href="https://2015.igem.org/Requirements">Requirements page </a> </li>
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<li> <a href="https://2015.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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</ul>
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<div class="highlightBox">
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<div style="padding-left:10%;padding-right:18%;font-size:11pt">
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<h4> Styling your wiki </h4>
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<center>
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<p>For this year's project the WLC-Milwaukee team is looking into phage therapy. Specifically we are looking for phages specific to the outer-membrane efflux pore protein tolC. tolC analogs are found in most gram-negative bacteria, and they have been implicated as an essential protein in an efflux-based resistance mechanism to certain types of antibiotics. Our project involves expressing tolC homologs from infectious strains of bacteria in a tolC knockout strain of E coli. We are using these transgenic E coli to search for bacteriophages specific to our selected gastrointestinal tract pathogen's versions of tolC. Our hope is that the phages specific for a pathogen's tolC can be used in combination with an antibiotic generally resisted via an efflux mechanism to put the pathogenic bacteria in a lose-lose dilemma: bacteria which try to efflux the antibiotics will expose themselves to the pathogen-specific phage, while those which do not express TolC will be weakened to the antibiotic therapy. </p>
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<div id="slideshow">
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
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<div class="textboxes" id="main_view">  
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    <div class="window"> <!--???-->
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        <div class="image_reel"> <!--Slideshow Pics go here - 760x280px -->
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            <a href=""><img src="https://static.igem.org/mediawiki/2015/1/11/SlideshowHome.png" width="870" height="300" alt="Slide 1" /></a>
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            <a href=""><img src="https://static.igem.org/mediawiki/2015/b/bd/WLC_Slide1_2015.png" width="870" height="300" alt="Slide 2" /></a>
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            <a href=""><img src="https://static.igem.org/mediawiki/2015/4/4e/HomeShowSlide2A.png" width="870" height="300" alt="Slide 3" /></a>
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            <a href=""><img src="https://static.igem.org/mediawiki/2015/a/ae/WLC_Slide3_2015.png" width="870" height="300" alt="Slide 4" /></a>
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            <a href=""><img src="https://static.igem.org/mediawiki/2015/8/8a/Slide5Replacement.png" width="870" height="300" alt="Slide 5" /></a>
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            <a href=""><img src="https://static.igem.org/mediawiki/2015/4/4b/WLC_Slide5_2015.png" width="870" height="300" alt="Slide 6" /></a>
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            <a href=""><img src="https://static.igem.org/mediawiki/2015/d/db/WLC_Slide6_2015.png" width="870" height="300" alt="Slide 7" /></a>
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        </div>
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    </div>
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    <div class="paging">
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        <a href="#" rel="1">1</a>
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        <a href="#" rel="2">2</a>
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        <a href="#" rel="3">3</a>
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        <a href="#" rel="4">4</a>
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        <a href="#" rel="5">5</a>
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        <a href="#" rel="6">6</a>
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        <a href="#" rel="7">7</a>
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    </div>
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<div class="pause"><a href="#">II</a></div>
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</center>
 
</div>
 
</div>
  
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<h4> Editing your wiki </h4>
 
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
 
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<p> <a href="https://2015.igem.org/wiki/index.php?title=Team:WLC-Milwaukee&action=edit"> Click here to edit this page! </a></p>
 
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<p>See tips on how to edit your wiki on the <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation</a> page.</p>
 
  
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<div class="highlightBox" style="padding-right:18%;padding-left:18%;">
  
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<h4>Templates </h4>
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<br />
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<p> This year we have created templates for teams to use freely. More information on how to use and edit the templates can be found on the
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<a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation </a> page.</p>  
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<br />
  
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<head>
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  <meta http-equiv="X-UA-Compatible" content="IE=Edge"> <!-- For intranet testing only, remove in production. -->
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  <meta content="text/html; charset=utf-8" http-equiv="Content-Type">
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  <title>Slide Show</title>
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<h4>Tips</h4>
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<center><h1 id="heading_1"> <font color="#610B0B", face="Tahoma" space="5"><b>Project Description</b></font> </h1></center><br/>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2015.igem.org/Calendar_of_Events">iGEM 2015 calendar</a> </li>
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<li>Have lots of fun! </li>
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</ul>  
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<p>The WLC-Milwaukee team is looking into phage therapy for this year's project. We are looking for phages specific to the outer-membrane efflux pore protein TolC. TolC analogs are found in most gram-negative bacteria, and they have been implicated as an essential protein in an efflux-based resistance mechanism to certain types of antibiotics. Our project involves expressing TolC homologs from infectious strains of bacteria in a <i>tolC</i> knockout strain of <i>Escherichia coli</i>. We are using these transgenic <i>E. coli</i> to search for bacteriophages specific to our selected gastrointestinal tract pathogen's versions of TolC. Our hope is that the phages specific for a pathogen's TolC protein can be used in combination with antibiotic therapy. This will place antibiotic resistant bacteria in a lose-lose situation: the bacteria which try to efflux the antibiotics via TolC will expose themselves to the pathogen's TolC-specific phage, while those which do not express TolC will be weakened to the antibiotic therapy.  </p>
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<center> <font size="4" color="#610B0B", face="Tahoma" space="5"><i>To Learn More, Click the Links Below</i></font></center>
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</div>
  
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<h4>Inspiration</h4>
 
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
 
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<ul>
 
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
 
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
 
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
 
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
 
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
 
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
 
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</ul>
 
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<h4> Uploading pictures and files </h4>
 
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<p> You can upload your pictures and files to the iGEM 2015 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
 
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
 
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<a href="https://2015.igem.org/Special:Upload">CLICK HERE TO UPLOAD FILES</a>
 
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<div id="wlcHeader" class="navLinks" style="left:0px;height:90px;width:100%;">
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<td style="width:15%"></td>
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<td id="HomeBox"><a id="homeLink" href="https://2015.igem.org/Team:WLC-Milwaukee" style="text-decoration:none" >Home</a></td>
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<td id="ProjectBox"><a id="projectLink" href="https://2015.igem.org/Team:WLC-Milwaukee/Project" style="text-decoration:none">Project</a></td>
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<td id="PartsBox"><a id="partsLink" href="https://2015.igem.org/Team:WLC-Milwaukee/Parts" style="text-decoration:none">Parts</a></td>
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<td id="NotebookBox"><a id="notebookLink" href="https://2015.igem.org/Team:WLC-Milwaukee/Notebook" style="text-decoration:none">Documentation</a></td>
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<td id="ModelingBox"><a id="modelingLink" href="https://2015.igem.org/Team:WLC-Milwaukee/Modeling" style="text-decoration:none">Modeling</a></td>
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<td id="practBox"><a id="practLink" href="https://2015.igem.org/Team:WLC-Milwaukee/Practices">Policy</a></td>
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<td id="teamBox"><a id="teamLink" href="https://2015.igem.org/Team:WLC-Milwaukee/Attributions">People</a></td>
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Latest revision as of 02:24, 19 September 2015

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II




Slide Show

Project Description


The WLC-Milwaukee team is looking into phage therapy for this year's project. We are looking for phages specific to the outer-membrane efflux pore protein TolC. TolC analogs are found in most gram-negative bacteria, and they have been implicated as an essential protein in an efflux-based resistance mechanism to certain types of antibiotics. Our project involves expressing TolC homologs from infectious strains of bacteria in a tolC knockout strain of Escherichia coli. We are using these transgenic E. coli to search for bacteriophages specific to our selected gastrointestinal tract pathogen's versions of TolC. Our hope is that the phages specific for a pathogen's TolC protein can be used in combination with antibiotic therapy. This will place antibiotic resistant bacteria in a lose-lose situation: the bacteria which try to efflux the antibiotics via TolC will expose themselves to the pathogen's TolC-specific phage, while those which do not express TolC will be weakened to the antibiotic therapy.


To Learn More, Click the Links Below