Difference between revisions of "Team:British Columbia"

 
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{{:Team:British Columbia/Template/Fixednavbar}}
  
 
<html>
 
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    <meta http-equiv="X-UA-Compatible" content="IE=edge">
 
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    <meta name="viewport" content="width=device-width, initial-scale=1">
 
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    <!-- The above 3 meta tags *must* come first in the head; any other head content must come *after* these tags -->
 
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    <meta name="description" content="">
 
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    <meta name="author" content="">
 
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    <link rel="icon" href="../../favicon.ico">
 
  
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    <title>Carousel Template for Bootstrap</title>
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<body id="UBC">
  
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    <!-- Bootstrap core CSS -->
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<body bgcolor="#f3dfba">
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    <link href="../../dist/css/bootstrap.min.css" rel="stylesheet">
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<br>
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<br>
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<br>
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<br><br><br><br>
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<p style="text-align:center;"><img src="https://static.igem.org/mediawiki/2015/thumb/a/ab/Banner_god.png/800px-Banner_god.png"></p>
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<br><br>
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<br>
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<br>
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<div id="text" style="margin-top:-250px;">
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<div style="margin:0 auto; width:1000px; margin-top:150px;">
  
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    <!-- Just for debugging purposes. Don't actually copy these 2 lines! -->
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<!--<div class="UBCt"><div id="UBCt">
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    <!--[if lt IE 9]><script src="../../assets/js/ie8-responsive-file-warning.js"></script><![endif]-->
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<div id="UBCtitle">
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     <script src="../../assets/js/ie-emulation-modes-warning.js"></script>
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<div id="one">&nbsp;</div>
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<div id="three"><h3>hover below</h3></div>
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     <div id="two">&nbsp;</div>
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</div></div></div>
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<div style="clear: both;"></div>
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<a id="homepageimg">
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<div id="homepageimg">
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</a>-->
  
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    <!-- HTML5 shim and Respond.js for IE8 support of HTML5 elements and media queries -->
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<div style="clear:both;"></div>
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    <!--[if lt IE 9]>
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  <ul>
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      <script src="https://oss.maxcdn.com/html5shiv/3.7.2/html5shiv.min.js"></script>
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    <img src="https://static.igem.org/mediawiki/2015/9/99/UBChomepageslide.png" width="915"; style = "padding-left: 75px;">
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      <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
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    <br><img src="https://static.igem.org/mediawiki/2015/3/3b/UBCOverviewtitle.png"; style = "padding-left: 275px">
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    <![endif]-->
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<div id="UBCbody" style="width:1000px; text-align:left;">
  
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    <!-- Custom styles for this template -->
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<p align="justify">Imagine a nice summer day outside in the meadows without the buzzing and humming of bees. It would be pretty quiet. But not only that. Probably, you also wouldn’t be able to enjoy the beauty of many flowers. And the crops on the field next to it wouldn't carry many fruits. This scenario may become reality in the near future because bees are dying on a massive scale. Honeybees are of great ecological and economical importance. They are responsible for the large-scale pollination of various plants like wild flowers and crops. It is estimated that honeybees pollinate $14 billion worth of crops per year in the United States alone. Worryingly, this economy is at risk because of substantial declines in honeybees.</p>
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    <link href="carousel.css" rel="stylesheet">
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<br>
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  </head>
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<center><img src="https://static.igem.org/mediawiki/2015/8/88/Bee_circle2.png" width="300px" align="middle"></center>
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<!-- NAVBAR
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<p align="justify">Since 2006, beekeepers report the dying of bees in large numbers. This phenomenon was termed <b>Colony Collapse Disorder (CCD)</b>. The cause of CCD is still not fully understood. Experts believe that multiple factors work in concert and cause the symptoms of CCD. Among these factors are parasites, like the varroa mite, bacterial diseases and virus infections, as well as pesticides. Neonicotinoid pesticides such as imidacloprid have been reported in the media to play a significant role in CCD. It was shown that neonicotinoids have a toxic effect on honeybees and may lead to behavioral changes of the worker bees, leading to the risk for a colony to forfeit their working forces. This has already driven the ban of neonicotinoids in the European Union. However, without these pesticides, farmers are facing large economic losses and have been forced to go back to more traditional pesticides that have an even more detrimental effect on the environment. But what can we do instead?</p>
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<p align="justify">Our project aims to provide a synthetic biology-based approach to solve one aspect on the issue around CCD and neonicotinoids.
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  <body>
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We are proposing to treat honeybees with engineered probiotic bacteria, or <i>probeeotics</i>, that protect the bees from the toxic effects of neonicotinoids. We are working with <i>Gilliamella apicola</i>, a native midgut bacterium specific to honeybees. We aim to engineer <i>G. apicola</i> to degrade imidacloprid into non-toxic compounds. By feeding this bacteria to honeybees, we believe honeybees will become less susceptible to common field doses of imidacloprid, which will reduce the risk of CCD. This approach will enable farmers to continue using neonicotinoids and benefit from the advantageous pest control characteristics while protecting the honeybees from their detrimental effects.</p>
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    <div class="navbar-wrapper">
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</div>
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      <div class="container">
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<br>
  
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        <nav class="navbar navbar-inverse navbar-static-top">
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<center><img src="https://static.igem.org/mediawiki/2015/c/ce/Flowchartubc.png" "controls style="width:750px;"></center>
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          <div class="container">
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<br>
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            <div class="navbar-header">
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<video poster="https://static.igem.org/mediawiki/2015/e/eb/British_ColumbiaVideoImage.jpg" controls style="width:1000px;">
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              <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false" aria-controls="navbar">
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<source src="https://static.igem.org/mediawiki/2015/3/3c/British_ColumbiaMovie.mp4"/>
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                <span class="sr-only">Toggle navigation</span>
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<p style="font-style:italic;color:red;border-style:solid;border-width:2px;border-color:red">Your browser either does not support HTML5 or cannot handle MediaWiki open video formats. Please consider upgrading your browser, installing the appropriate plugin or switching to a Firefox or Chrome install.</p>
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                <span class="icon-bar"></span>
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</video>
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                <span class="icon-bar"></span>
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                <span class="icon-bar"></span>
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              <a class="navbar-brand" href="#">Project name</a>
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            <div id="navbar" class="navbar-collapse collapse">
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              <ul class="nav navbar-nav">
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                <li class="active"><a href="#">Home</a></li>
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                <li><a href="#about">About</a></li>
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                <li><a href="#contact">Contact</a></li>
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                <li class="dropdown">
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                  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">Dropdown <span class="caret"></span></a>
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                  <ul class="dropdown-menu" role="menu">
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                    <li><a href="#">Action</a></li>
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                    <li><a href="#">Another action</a></li>
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                    <li><a href="#">Something else here</a></li>
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                    <li class="divider"></li>
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                    <li class="dropdown-header">Nav header</li>
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                    <li><a href="#">Separated link</a></li>
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                    <li><a href="#">One more separated link</a></li>
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                  </ul>
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                </li>
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              </ul>
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            </div>
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          </div>
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        </nav>
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      </div>
 
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    </div>
 
  
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    </body>
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  </ul> 
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</br>
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</br>
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</br></br></br></br></br></br>
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</br>
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</div>
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</div>
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</div>
  
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    <!-- Carousel
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</body>
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    ================================================== -->
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    <div id="myCarousel" class="carousel slide" data-ride="carousel">
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      <!-- Indicators -->
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      <ol class="carousel-indicators">
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        <li data-target="#myCarousel" data-slide-to="0" class="active"></li>
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        <li data-target="#myCarousel" data-slide-to="1"></li>
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        <li data-target="#myCarousel" data-slide-to="2"></li>
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      </ol>
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      <div class="carousel-inner" role="listbox">
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        <div class="item active">
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          <img class="first-slide" src="data:image/gif;base64,R0lGODlhAQABAIAAAHd3dwAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw==" alt="First slide">
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          <div class="container">
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            <div class="carousel-caption">
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              <h1>Example headline.</h1>
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              <p>Note: If you're viewing this page via a <code>file://</code> URL, the "next" and "previous" Glyphicon buttons on the left and right might not load/display properly due to web browser security rules.</p>
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              <p><a class="btn btn-lg btn-primary" href="#" role="button">Sign up today</a></p>
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            </div>
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          </div>
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        </div>
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        <div class="item">
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          <img class="second-slide" src="data:image/gif;base64,R0lGODlhAQABAIAAAHd3dwAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw==" alt="Second slide">
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          <div class="container">
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            <div class="carousel-caption">
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              <h1>Another example headline.</h1>
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              <p>Cras justo odio, dapibus ac facilisis in, egestas eget quam. Donec id elit non mi porta gravida at eget metus. Nullam id dolor id nibh ultricies vehicula ut id elit.</p>
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              <p><a class="btn btn-lg btn-primary" href="#" role="button">Learn more</a></p>
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            </div>
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          </div>
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        </div>
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        <div class="item">
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          <img class="third-slide" src="data:image/gif;base64,R0lGODlhAQABAIAAAHd3dwAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw==" alt="Third slide">
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          <div class="container">
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            <div class="carousel-caption">
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              <h1>One more for good measure.</h1>
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              <p>Cras justo odio, dapibus ac facilisis in, egestas eget quam. Donec id elit non mi porta gravida at eget metus. Nullam id dolor id nibh ultricies vehicula ut id elit.</p>
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              <p><a class="btn btn-lg btn-primary" href="#" role="button">Browse gallery</a></p>
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            </div>
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          </div>
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        </div>
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      </div>
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      <a class="left carousel-control" href="#myCarousel" role="button" data-slide="prev">
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        <span class="glyphicon glyphicon-chevron-left" aria-hidden="true"></span>
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        <span class="sr-only">Previous</span>
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      </a>
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      <a class="right carousel-control" href="#myCarousel" role="button" data-slide="next">
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        <span class="glyphicon glyphicon-chevron-right" aria-hidden="true"></span>
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        <span class="sr-only">Next</span>
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      </a>
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    </div><!-- /.carousel -->
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    <!-- Marketing messaging and featurettes
 
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    ================================================== -->
 
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    <!-- Wrap the rest of the page in another container to center all the content. -->
 
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    <div class="container marketing">
 
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      <!-- Three columns of text below the carousel -->
 
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      <div class="row">
 
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        <div class="col-lg-4">
 
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          <img class="img-circle" src="data:image/gif;base64,R0lGODlhAQABAIAAAHd3dwAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw==" alt="Generic placeholder image" width="140" height="140">
 
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          <h2>Heading</h2>
 
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          <p>Donec sed odio dui. Etiam porta sem malesuada magna mollis euismod. Nullam id dolor id nibh ultricies vehicula ut id elit. Morbi leo risus, porta ac consectetur ac, vestibulum at eros. Praesent commodo cursus magna.</p>
 
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          <p><a class="btn btn-default" href="#" role="button">View details &raquo;</a></p>
 
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          <img class="img-circle" src="data:image/gif;base64,R0lGODlhAQABAIAAAHd3dwAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw==" alt="Generic placeholder image" width="140" height="140">
 
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          <h2>Heading</h2>
 
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          <p>Duis mollis, est non commodo luctus, nisi erat porttitor ligula, eget lacinia odio sem nec elit. Cras mattis consectetur purus sit amet fermentum. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh.</p>
 
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          <p><a class="btn btn-default" href="#" role="button">View details &raquo;</a></p>
 
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        <div class="col-lg-4">
 
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          <img class="img-circle" src="data:image/gif;base64,R0lGODlhAQABAIAAAHd3dwAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw==" alt="Generic placeholder image" width="140" height="140">
 
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          <h2>Heading</h2>
 
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          <p>Donec sed odio dui. Cras justo odio, dapibus ac facilisis in, egestas eget quam. Vestibulum id ligula porta felis euismod semper. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus.</p>
 
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          <p><a class="btn btn-default" href="#" role="button">View details &raquo;</a></p>
 
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        </div><!-- /.col-lg-4 -->
 
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      </div><!-- /.row -->
 
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      <!-- START THE FEATURETTES -->
 
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      <hr class="featurette-divider">
 
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      <div class="row featurette">
 
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        <div class="col-md-7">
 
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          <h2 class="featurette-heading">First featurette heading. <span class="text-muted">It'll blow your mind.</span></h2>
 
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          <p class="lead">Donec ullamcorper nulla non metus auctor fringilla. Vestibulum id ligula porta felis euismod semper. Praesent commodo cursus magna, vel scelerisque nisl consectetur. Fusce dapibus, tellus ac cursus commodo.</p>
 
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        </div>
 
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        <div class="col-md-5">
 
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          <img class="featurette-image img-responsive center-block" data-src="holder.js/500x500/auto" alt="Generic placeholder image">
 
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      <hr class="featurette-divider">
 
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      <div class="row featurette">
 
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        <div class="col-md-7 col-md-push-5">
 
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          <h2 class="featurette-heading">Oh yeah, it's that good. <span class="text-muted">See for yourself.</span></h2>
 
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          <p class="lead">Donec ullamcorper nulla non metus auctor fringilla. Vestibulum id ligula porta felis euismod semper. Praesent commodo cursus magna, vel scelerisque nisl consectetur. Fusce dapibus, tellus ac cursus commodo.</p>
 
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        <div class="col-md-5 col-md-pull-7">
 
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      <div class="row featurette">
 
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        <div class="col-md-7">
 
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          <h2 class="featurette-heading">And lastly, this one. <span class="text-muted">Checkmate.</span></h2>
 
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          <p class="lead">Donec ullamcorper nulla non metus auctor fringilla. Vestibulum id ligula porta felis euismod semper. Praesent commodo cursus magna, vel scelerisque nisl consectetur. Fusce dapibus, tellus ac cursus commodo.</p>
 
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          <img class="featurette-image img-responsive center-block" data-src="holder.js/500x500/auto" alt="Generic placeholder image">
 
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        </div>
 
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      <hr class="featurette-divider">
 
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      <!-- /END THE FEATURETTES -->
 
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      <!-- FOOTER -->
 
−
      <footer>
 
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        <p class="pull-right"><a href="#">Back to top</a></p>
 
−
        <p>&copy; 2014 Company, Inc. &middot; <a href="#">Privacy</a> &middot; <a href="#">Terms</a></p>
 
−
      </footer>
 
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    </div><!-- /.container -->
 
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    <!-- Bootstrap core JavaScript
 
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    ================================================== -->
 
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    <script src="https://ajax.googleapis.com/ajax/libs/jquery/1.11.2/jquery.min.js"></script>
 
−
    <script src="../../dist/js/bootstrap.min.js"></script>
 
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  </body>
 
 
</html>
 
</html>
 +
{{:Team:British Columbia/Template/Fixedfooter}}

Latest revision as of 03:56, 19 September 2015

UBC iGEM 2015













    Imagine a nice summer day outside in the meadows without the buzzing and humming of bees. It would be pretty quiet. But not only that. Probably, you also wouldn’t be able to enjoy the beauty of many flowers. And the crops on the field next to it wouldn't carry many fruits. This scenario may become reality in the near future because bees are dying on a massive scale. Honeybees are of great ecological and economical importance. They are responsible for the large-scale pollination of various plants like wild flowers and crops. It is estimated that honeybees pollinate $14 billion worth of crops per year in the United States alone. Worryingly, this economy is at risk because of substantial declines in honeybees.


    Since 2006, beekeepers report the dying of bees in large numbers. This phenomenon was termed Colony Collapse Disorder (CCD). The cause of CCD is still not fully understood. Experts believe that multiple factors work in concert and cause the symptoms of CCD. Among these factors are parasites, like the varroa mite, bacterial diseases and virus infections, as well as pesticides. Neonicotinoid pesticides such as imidacloprid have been reported in the media to play a significant role in CCD. It was shown that neonicotinoids have a toxic effect on honeybees and may lead to behavioral changes of the worker bees, leading to the risk for a colony to forfeit their working forces. This has already driven the ban of neonicotinoids in the European Union. However, without these pesticides, farmers are facing large economic losses and have been forced to go back to more traditional pesticides that have an even more detrimental effect on the environment. But what can we do instead?

    Our project aims to provide a synthetic biology-based approach to solve one aspect on the issue around CCD and neonicotinoids. We are proposing to treat honeybees with engineered probiotic bacteria, or probeeotics, that protect the bees from the toxic effects of neonicotinoids. We are working with Gilliamella apicola, a native midgut bacterium specific to honeybees. We aim to engineer G. apicola to degrade imidacloprid into non-toxic compounds. By feeding this bacteria to honeybees, we believe honeybees will become less susceptible to common field doses of imidacloprid, which will reduce the risk of CCD. This approach will enable farmers to continue using neonicotinoids and benefit from the advantageous pest control characteristics while protecting the honeybees from their detrimental effects.