Difference between revisions of "Team:Fudan"
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<p>We are working really hard to the outreach activities!</p> | <p>We are working really hard to the outreach activities!</p> | ||
<p>One of the major work we focus on is the popularization of science. Inspired by one of the major incident in the debating of transgenic technology in China, our team hold six successful lecture in our university to share the basic knowledge of different areas of biology. We are not satisfied with our achievements on the campus, so we search places outside our university to make more difference. We work hard to get the chance to give a speech to all the students in a high school; we explain the simple principle of transgenic food to the passengers and hand out leaflets on the street; we introduced our project to visitors in Shanghai Science&Technology Museum. </p> | <p>One of the major work we focus on is the popularization of science. Inspired by one of the major incident in the debating of transgenic technology in China, our team hold six successful lecture in our university to share the basic knowledge of different areas of biology. We are not satisfied with our achievements on the campus, so we search places outside our university to make more difference. We work hard to get the chance to give a speech to all the students in a high school; we explain the simple principle of transgenic food to the passengers and hand out leaflets on the street; we introduced our project to visitors in Shanghai Science&Technology Museum. </p> | ||
| − | <p>Besides all these activity, we also run the daily activity of Betalanffy Association, which is a famous community belonging to our iGEM team. <a href=" | + | <p>Besides all these activity, we also run the daily activity of Betalanffy Association, which is a famous community belonging to our iGEM team. <a href="http://songhao.iok.la/iGEM_Fudan/results.html">See more...</a></p> |
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<div class = "team_title" style="display: none;"> | <div class = "team_title" style="display: none;"> | ||
Revision as of 22:24, 1 October 2015
Circular RNAs (circRNAs), formed by non-sequential back-splicing of pre-mRNA transcripts, are a wide- spread form of non-coding RNA in animal cells. Various function of natural existed circRNA revealed recently shows that circRNA can be used as powerful tools in future research and health care. However, there is no toolbox to generate circRNA up to date, which restrict the research and application of circRNA. Our project focus on the devices to cyclize specific part of RNA, aiming to start a circRNA revolution.
We designed three types of devices to cyclize the RNA based on the back-splicing mechanism:the "Ouroboros"(cyclizing device based on the inverted repeat sequence in the exon-flanking region), the "Cyclizer"(proteins that accelerate RNA cyclization)and the acRNA(ssRNA that accelerate RNA cyclization).
We experimentally validate that our device can accelerate the formation of cirRNA. We also measured the half-life time of the circRNA, which proved its stability. To solidity our experiment procedure, we designed a device to report the level of mir-21 concentration and modeled the steady state of proteins to confirm our design.
Apart from our lab work, we also took active part in the educational outreach activities which has had huge influences on and off campus. As sociable participants in iGEM, we have collaboration with NYU_Shanghai, ZJU-China and NCTU Formosa, and mentored a high school team WLSA_Fudan-Shanghai. See more...
