Difference between revisions of "Team:NJU-China/Modeling"

 
(25 intermediate revisions by one other user not shown)
Line 1: Line 1:
 
<!-- saved from url=(0029)http://thefounderspledge.org/ -->
 
<!-- saved from url=(0029)http://thefounderspledge.org/ -->
−
<html>
+
<html><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
−
<head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+
 
<meta charset="utf-8">
 
<meta charset="utf-8">
 
<!-- Always force latest IE rendering engine or request Chrome Frame -->
 
<!-- Always force latest IE rendering engine or request Chrome Frame -->
Line 7: Line 6:
 
<meta content="width=device-width, initial-scale=1.0, maximum-scale=1.0" name="viewport">
 
<meta content="width=device-width, initial-scale=1.0, maximum-scale=1.0" name="viewport">
 
<!-- Use title if it's in the page YAML frontmatter -->
 
<!-- Use title if it's in the page YAML frontmatter -->
−
<title>model</title>
+
<title>humanpractice</title>
 +
 
  
 
<meta content="#ffffff" name="msapplication-TileColor">
 
<meta content="#ffffff" name="msapplication-TileColor">
Line 19: Line 19:
 
<link href="https://2015.igem.org/Template:NJU-China/CSS3?action=raw&ctype=text/css" rel="stylesheet" type="text/css">
 
<link href="https://2015.igem.org/Template:NJU-China/CSS3?action=raw&ctype=text/css" rel="stylesheet" type="text/css">
 
<link href="https://2015.igem.org/Template:NJU-China/CSS4?action=raw&ctype=text/css" rel="stylesheet" type="text/css">
 
<link href="https://2015.igem.org/Template:NJU-China/CSS4?action=raw&ctype=text/css" rel="stylesheet" type="text/css">
 +
 +
 
<style type="text/css">
 
<style type="text/css">
−
  #nav {
+
 
−
                line-height: 24px; list-style-type: none;
+
−
            }
+
−
            #nav a {
+
−
                display: block;
+
−
            }
+
−
            #nav a:link {
+
−
                color:#666; text-decoration:none;
+
−
            }
+
−
            #nav a:visited {
+
−
                color:#666;text-decoration:none;
+
−
            }
+
−
            #nav a:hover {
+
−
                color:#FFF;text-decoration:none;font-weight:bold;
+
−
            }
+
−
            #nav li {
+
−
                float: left;
+
−
            }
+
−
            #nav li a:hover{
+
−
                background:#999;
+
−
            }
+
−
            #nav li ul {
+
−
                line-height: 27px; list-style-type: none;text-align:left; position: absolute;display: none;
+
−
            }
+
−
            #nav li ul li{
+
−
                float: left;
+
−
                background: #F6F6F6;
+
−
            }
+
−
            #nav li ul a{
+
−
                display: block;text-align:left;padding-left:24px;
+
−
            }
+
−
            #nav li ul a:link {
+
−
                color:#666; text-decoration:none;
+
−
            }
+
−
            #nav li ul a:visited {
+
−
                color:#666;text-decoration:none;
+
−
            }
+
−
            #nav li ul a:hover {
+
−
                color:#F3F3F3;text-decoration:none;font-weight:normal;
+
−
            }
+
 
body {
 
body {
 
  background-image: url(https://static.igem.org/mediawiki/2014/b/bd/HUST_Background_3.jpg);
 
  background-image: url(https://static.igem.org/mediawiki/2014/b/bd/HUST_Background_3.jpg);
Line 125: Line 88:
 
     background-color: transparent;   
 
     background-color: transparent;   
 
}
 
}
 +
 
#top-section {
 
#top-section {
 
     background-color:4848;
 
     background-color:4848;
Line 134: Line 98:
 
     position: fixed;
 
     position: fixed;
 
}
 
}
 +
  
 
#menubar {
 
#menubar {
Line 140: Line 105:
 
     font-size: 14px;
 
     font-size: 14px;
 
}
 
}
 +
 +
.new {
 +
    color:white;
 +
}
 +
 
a, a:visited {
 
a, a:visited {
 
     color: #ADADAD;
 
     color: #ADADAD;
 
     text-decoration: none;
 
     text-decoration: none;
−
}
+
     font-weight:bold;
−
 
+
−
.new {
+
−
     color:white;
+
 
}
 
}
  
 
a:hover {
 
a:hover {
−
     color: white;
+
     color: black;
 +
    font-weight:bold;
 
     text-decoration: underline;
 
     text-decoration: underline;
 
}
 
}
−
 
−
 
−
 
  
 
#apDiv_Logo_iGEM {
 
#apDiv_Logo_iGEM {
Line 176: Line 141:
 
     #nav.dyn li ul.show{ display:block;}  
 
     #nav.dyn li ul.show{ display:block;}  
 
     #nav.dyn li{ padding-left:15px;line-height:250%}  
 
     #nav.dyn li{ padding-left:15px;line-height:250%}  
−
 
−
 
−
 
−
 
−
 
 
</style>  
 
</style>  
  
−
<script type="text/javascript">
 
−
$(function() {
 
−
                $("#nav>li").hover(
 
−
                        function() {
 
−
                            $(this).find("ul").show(300);
 
−
                        },
 
−
                        function() {
 
−
                            $(this).find("ul").hide(1000);
 
−
                        }
 
−
                );
 
−
            });
 
−
</script>
 
  
 
</head>
 
</head>
Line 241: Line 189:
 
<TABLE borderColor=#00ff99 height="100%" width="100%" border=0 style="table-layout:fixed">
 
<TABLE borderColor=#00ff99 height="100%" width="100%" border=0 style="table-layout:fixed">
 
     <TR height="100%">
 
     <TR height="100%">
−
<TD width="27%" bgColor=#EEE8AA style="vertical-align:top">
+
<TD width="27%" bgColor=#E6E8FA style="vertical-align:top">
−
<ul id="nav" class="dyn" style="height:100px;line-height:100px;margin-top:20%;margin-left:10%;list-style-type:none">
+
</br>
−
<li><a href="https://2015.igem.org/Team:NJU-China" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Home</a></li></br>
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Home</a></li>
−
<li><a href="https://2015.igem.org/NJU-China-background.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Background</a></li></br>
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-background.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Background</a></li>
−
<li><a href="https://2015.igem.org/NJU-China-project.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Project</a></li></br>
+
<div style="line-height:250%;margin-left:10%" id="main1" onClick="document.all.child0.style.display=(document.all.child0.style.display =='none')?'':'none'" ><a href="#" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Project</a></div>
−
<li><a href="#" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Model</a>
+
<div id="child0" style="display:none">
−
        <ul>  
+
<ul>
−
            <li><a href="https://2015.igem.org/Team:NJU-China/Modeling.html#deliverymodel" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Delivery model</a></li>  
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/Design" style="font-weight:bold;font-family:幼圆;color:black">design</a></li>
−
            <li><a href="https://2015.igem.org/Team:NJU-China/Modeling#" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">RNAi model</a></li>  
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-project/result.html" style="font-weight:bold;font-family:幼圆;color:black">results</a></li>
−
        </ul>  
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-project/conclusion.html" style="font-weight:bold;font-family:幼圆;color:black">conclusion</a></li>
−
</li></br>
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-project/future work.html" style="font-weight:bold;font-family:幼圆;color:black">future work</a></li>
−
<li style="line-height:250%"><a href="https://2015.igem.org/Team:NJU-China/Practices" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Human Practice</a></li></br>
+
</ul>
−
<li style="line-height:250%"><a href="https://2015.igem.org/NJU-China-parts.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Parts</a></li></br>
+
</div>
−
<li style="line-height:250%"><a href="https://2015.igem.org/NJU-China-team.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Team</a></li></br>
+
<div style="line-height:250%;margin-left:10%" id="main1" onClick="document.all.child1.style.display=(document.all.child1.style.display =='none')?'':'none'" ><a href="#" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Model</a></div>
−
<li style="line-height:250%"><a href="https://2015.igem.org/Team:NJU-China/Attributions" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Attribution</a></li></br>
+
<div id="child1" style="display:none">
−
<li style="line-height:250%"><a href="https://2015.igem.org/Team:NJU-China/Collaborations" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Colaborations</a></li></br>
+
<ul>
−
<li style="line-height:250%"><a href="https://2015.igem.org/NJU-China-safty.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Safety</a></li></br>
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-model.html" style="font-weight:bold;font-family:幼圆;color:black">Delivery Module</a></li>
−
<li style="line-height:250%"><a href="#" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Notebook</a>
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/RNAi" style="font-weight:bold;font-family:幼圆;color:black">RNAi Module</a></li>
−
        <ul>  
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/signaling" style="font-weight:bold;font-family:幼圆;color:black">Signaling Module</a></li>
−
            <li><a href="https://2015.igem.org/NJU-China-notebook.html#methods" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Methods</a></li>  
+
</ul>
−
            <li><a href="https://2015.igem.org/NJU-China-notebook.html#protocal" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Protocal</a></li>  
+
</div>
−
            <li><a href="https://2015.igem.org/NJU-China-notebook.html#notebook" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Notebook</a></li>  
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/Practices" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Human Practice</a></li>
−
        </ul>  
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-parts.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Parts</a></li>
−
</li></br>
+
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-team.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Team</a></li>
 +
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-attribution.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Attribution</a></li>
 +
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/Team:NJU-China/Collaborations" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Colaborations</a></li>
 +
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-safty.html" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Safety</a></li>
 +
<div style="line-height:250%;margin-left:10%" id="main2" onClick="document.all.child2.style.display=(document.all.child2.style.display =='none')?'':'none'" > <a href="#" style="font-weight:bold;font-family:幼圆;font-size:25px;color:black">Notebook </div>
 +
<div id="child2" style="display:none">
 +
<ul>
 +
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-notebook.html#methods" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Methods</a></li>
 +
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-notebook.html#protocal" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Protocal</a></li>
 +
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-notebook.html#notebook" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Notebook</a></li>
 +
</ul>
 +
</div>
 +
<li style="line-height:250%;margin-left:10%"><a href="https://2015.igem.org/NJU-China-acknowledgement.html#notebook" style="font-weight:bold;font-family:幼圆;font-size:20px;color:black">Acknowledgement</a></li>
  
−
</ul>
 
 
</TD>
 
</TD>
 
     <TD width="73%" bgColor=#FFFFFF style="vertical-align:top;padding-left:80px;padding-right:80px;padding-top:50px;padding-bottom:50px;word-wrap:break-word;">
 
     <TD width="73%" bgColor=#FFFFFF style="vertical-align:top;padding-left:80px;padding-right:80px;padding-top:50px;padding-bottom:50px;word-wrap:break-word;">
−
你在火中涅槃，灵魂不死；你在花间长眠，记忆不消。绚烂的阳光是迎接你西去的光环，不知你独自一人去那方可会感到孤单？
+
<h1> Modeling overview </h1>
−
[一]魂去
+
 
−
      起初听到你的死，我是愕然的。毕竟听说你的病情好了不少，却不料那只是最后的回光返照。
+
We created mathematical models of three aspects of our project: a
−
      我没有流泪，甚至没有悲伤，脑子里只是混混沌沌的一团。死？那是我们所有人最后的归宿吧。或许于你更是能够减少痛苦，未尝不是一件好事。
+
 
−
      一切被我想得太简单，甚至太过理所当然了。理智，真是一个可怕的局。
+
pharmacokinetic model, RNA inference model and signaling network model.
−
[二]席间
+
 
−
      小号、大鼓敲个不停，那种声音不得不说是一种噪音。良久声止，开始一个个念悼词。
+
The source code of the modeling work is available <a href="https://static.igem.org/mediawiki/2015/4/4a/Model_Code.zip">here</a> or on our <a href="https://github.com/eldronzhou/IGEM-NJU-China-2015">Github Page</a> to help others
−
      我这时才发现，原来我并没有那么冷漠，缘是城市的喧嚣麻木了我的心。想起那年你的温言软语、慈爱笑容，泪竟是就这样忍不住地从眼眶中溢出了。我撇过头，不愿让人看见，嘴角仍是挂着笑容。
+
 
−
      呵呵，我竟觉着在这葬礼上哭泣都是可耻的。望着周围人谈笑风生，我的心有点寒。到场的那么多人，究竟又有几个是真心的呢？可怜，还是可悲啊？
+
reproduce and improve our work. <br><br>
−
      原来人可以铁石心肠这种程度，可毕竟他们中很多人比我和你的关系更近啊！听着那个花钱雇来哭的人呜咽，看着那人热泪纵横，我终是忍不住苦笑，竟是一个毫不相识的外人哭得最伤心。这是讽刺，还是笑话？
+
 
−
  [三]送葬
+
 
−
      你说，为什么他们还能那样淡然，可我偏偏忍不住泪流满面？为什么他们那个惊讶的表情让我竟是感到羞愧？好像自己做了什么惊天动地的事一样？
+
The delivery module used experimental results to simulate the kinetics
−
      执着一根香，撒下一碗酒，三拜三叩，泪融于酒，我如若痴人。
+
 
−
      照礼我是不必披麻戴孝的，只需戴着那顶白色的帽子即可。沿着幽僻的小路，我跟着吹着小号开路的队伍走在末尾。
+
of tissue-distribution of exosomes. The RNAi module modeled the
−
       风景甚好，埋在那棵大树底下，你会不会成为那树的枝，树的叶？
+
 
−
[四]感怀
+
kinetics of downregualtion of MOR protein in response to anti-MOR
−
      死生有命，无可更改。谋事在人，成事在天。任你生前浮华万千，到头来不过一抔尘土，一捧青灰。愿逝者安息，生者恬淡。
+
 
−
      有时候我们看不到自己拥有的美好，直到失去才恍然叹息。逝者已矣，页已掀过，惜福、感恩，生活其实温暖如花。
+
siRNA. The signaling module theoretically predicted the impacts of
−
      花开半夏，倾尽繁华，愿你回眸半刹。你可听到我在同你夜话？
+
 
 +
downregulating MOR protein on the reward pathway and explained the
 +
 
 +
behavioral change of mice observed in our laratory work. We had a
 +
 
 +
better understanding of our device by integrating three modules.
 +
<br><br>
 +
 
 +
       <img src="https://static.igem.org/mediawiki/2015/5/59/NJU-China-Model_Figure0.jpg" style="width:800px;height:400px">
 +
<!--插入第一幅图--> <br><br> 
 +
 
 +
 
 +
 
 
</TD>
 
</TD>
 
     </TR>
 
     </TR>

Latest revision as of 03:36, 3 October 2015

humanpractice


  • Home
  • Background
  • Human Practice
  • Parts
  • Team
  • Attribution
  • Colaborations
  • Safety
  • Acknowledgement
    		•

    Modeling overview

    We created mathematical models of three aspects of our project: a pharmacokinetic model, RNA inference model and signaling network model. The source code of the modeling work is available here or on our Github Page to help others reproduce and improve our work.

    The delivery module used experimental results to simulate the kinetics of tissue-distribution of exosomes. The RNAi module modeled the kinetics of downregualtion of MOR protein in response to anti-MOR siRNA. The signaling module theoretically predicted the impacts of downregulating MOR protein on the reward pathway and explained the behavioral change of mice observed in our laratory work. We had a better understanding of our device by integrating three modules.