Difference between revisions of "Team:Korea U Seoul/Team/Attributions/content"

 
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                  Background
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                  Attributions
 
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    Sortases, enzymes that recognize and cleave the specific sorting signal of secreted proteins to form isopeptide bonds between the secreted proteins and polypeptides, function as protein ligase to form the cell-wall surface of gram-positive bacteria. In case of <i>C.diphtheriae</i>, which belongs to the same genus of our experimental bacteria <i>Corynebacterium glutamicum</i>, has total of 6 sortases, 5 pilus specific sortases (Srt A,B,C,D,E) and 1 housekeeping sortase (Srt F) involved in the formation of all types of pili. <br />
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    <h1>Software Backend</h1>
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There are 9 types of pillins that comprise pilus; Spa A, B, C, D, E, F, G, H, I, J. SrtA build up SpaA-type pili, which is composed of Spa A, B and C. Srt B/C and Srt d/E each forms SpaD-type pili and SpaH-type pili, which is made up of Spa D, E, F and Spa H, I, J respectively. Like this, the names of each pili types are generally from the names of many Spa proteins. <br />
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        <h3>Data Collection: Deok ho Kim, Sumin Cho, Seong-ju Lee, Jiwon Kim</h3>
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The picture below shows the process of SpaA type pili formation, using SrtA. Sortase class A enzymes recognize the sequence LPXTG at the carboxyl terminus of surface protein precursors. Cystein of SrtA recognizes LPXTG motif of SpaC, cleaves between T and G, forming SpaC-SrtA intermediate via nucleophilic attack. This intermediate is again attacked by lysine of SrtA bounded SpaA, and the process is continued to form SpaC–SpaAn–SrtA intermediates.<br />
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<h3>Pathway Scoring: Jeongsu Hwang, SooWhan Kim, Sumin Cho, Seong-ju Lee, Jiwon Kim</h3>
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Nucleophilic attack by Lysine of SrtF bounded SpaB form SpaC-SpaA(n)-SpaB-SrtF intermediate. The product of this SrtA reaction is covalently linked to lipidⅡ and is then incorporated into the cell wall envelope, terminating the formation of SpaA-type pilus.
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<h3>Database Contruction: Sumin Cho, Seong-ju Lee, Jiwon Kim</h3>
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<h1>Software Frontend</h1>
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<h3>UI & Web Design : Kyeong-hun Jeong, Min ki Choi, Deok ho Kim, Hyeong Woo Kim </h3>
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<h3>Data visualization : Kyeong-hun Jeong</h3>
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<h3>Tutorial & User Guide : Min ki Choi, Hyeong Woo Kim, JuYoung Han, Kyeong-hun Jeong</h3>
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<h3></h3>
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<h1>Wet-lab Work</h1>
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<h3>Kyujin Jeong, HyeYeong, JuYoung Han, Junhee Kim, Eun San Ko</h3>
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<h3></h3>
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<h1>Wiki</h1>
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<h3>Editing: Jiwon Kim</h3>
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<h3>Writing: All team members</h3>
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<h3>Tranlation: JuYoung Han, HyeYeong, Kyujin Jeong, Jiseung Lee</h3>
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<h3>Web Design and Publishing: Min ki Choi, Kyeong-hun Jeong</h3>
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<h3></h3>
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<h1>Funding</h1>
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<h3>All team members</h3>
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<h3></h3>
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<h1>Presentation</h1>
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<h3>Deok ho Kim, SooWhan Kim, Kyujin Jeong, Jiseung Lee</h3>
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<h3></h3>
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<h1>Design</h1>
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<h3>Hyeong Woo Kim</h3>
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<h3></h3>
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<h1>Human Practices</h1>
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<h3>All team members</h3>
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<h3></h3>
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<h1>Instructor</h1>
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<h3>Byeong-nam Min, Kyoungwoo Jang, and Prof. In Geol Choi</h3>
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<h3></h3>
 
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Latest revision as of 13:43, 10 October 2015

Attributions

Software Backend

Data Collection: Deok ho Kim, Sumin Cho, Seong-ju Lee, Jiwon Kim

Pathway Scoring: Jeongsu Hwang, SooWhan Kim, Sumin Cho, Seong-ju Lee, Jiwon Kim

Database Contruction: Sumin Cho, Seong-ju Lee, Jiwon Kim

Software Frontend

UI & Web Design : Kyeong-hun Jeong, Min ki Choi, Deok ho Kim, Hyeong Woo Kim

Data visualization : Kyeong-hun Jeong

Tutorial & User Guide : Min ki Choi, Hyeong Woo Kim, JuYoung Han, Kyeong-hun Jeong

Wet-lab Work

Kyujin Jeong, HyeYeong, JuYoung Han, Junhee Kim, Eun San Ko

Wiki

Editing: Jiwon Kim

Writing: All team members

Tranlation: JuYoung Han, HyeYeong, Kyujin Jeong, Jiseung Lee

Web Design and Publishing: Min ki Choi, Kyeong-hun Jeong

Funding

All team members

Presentation

Deok ho Kim, SooWhan Kim, Kyujin Jeong, Jiseung Lee

Design

Hyeong Woo Kim

Human Practices

All team members

Instructor

Byeong-nam Min, Kyoungwoo Jang, and Prof. In Geol Choi