Difference between revisions of "Team:NRP-UEA-Norwich/Practices"

 
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                                       <li class="dropdown " id="dropdown"><a href="#" class="dropdown-toggle"  data-toggle="dropdown">Project</a>
 
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                                        <li ><a href="/Team:NRP-UEA-Norwich/Description">Overview</a></li>
 
                                         <li ><a href="/Team:NRP-UEA-Norwich/Project">Background</a></li>
 
                                         <li ><a href="/Team:NRP-UEA-Norwich/Project">Background</a></li>
 
                                         <li ><a href="/Team:NRP-UEA-Norwich/Approach">Approach</a></li>
 
                                         <li ><a href="/Team:NRP-UEA-Norwich/Approach">Approach</a></li>
 
                                         <li ><a href="/Team:NRP-UEA-Norwich/Results">Results</a></li>
 
                                         <li ><a href="/Team:NRP-UEA-Norwich/Results">Results</a></li>
                                        <li ><a href="/Team:NRP-UEA-Norwich/Parts">Parts</a></li>
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                                        <li ><a href="/Team:NRP-UEA-Norwich/Parts">Parts</a></li>
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                                        <li ><a href="/Team:NRP-UEA-Norwich/Notebook">Timeline</a></li>                                   
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                                       </ul>
 
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                                     <li class="dropdown " id="dropdown"><a href="#" class="dropdown-toggle" data-toggle="dropdown">Modelling</a>
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                                         <li ><a href="/Team:NRP-UEA-Norwich/Modeling/Glyco2D">Glyco2D</a></li>
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                                         <li ><a href="/Team:NRP-UEA-Norwich/Software">Glyco2D</a></li>
                                        <li ><a href="/Team:NRP-UEA-Norwich/Modeling/Simulation">Acylation Simulation</a></li>
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                                         <li ><a href="/Team:NRP-UEA-Norwich/Modeling/3D">3D Models</a></li>
 
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                                         <li ><a href="/Team:NRP-UEA-Norwich/Modeling/HowTo">How to Build 3D Models</a></li>
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                                         <li ><a href="/Team:NRP-UEA-Norwich/Modeling">Kinetic Model</a></li>                                
                                        <li ><a href="/Team:NRP-UEA-Norwich/Modeling/Kinetic">Kinetic Model</a></li>
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                                        <li ><a href="/Team:NRP-UEA-Norwich/Modeling/3DPrinting">How to 3D Print Molecules</a></li>                                   
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                                     <li  ><a href="/Team:NRP-UEA-Norwich/Attributions">Attributions</a></li>
 
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                                     <li  ><a href="/Team:NRP-UEA-Norwich/Practices">Practices</a></li>
 
                                     <li  ><a href="/Team:NRP-UEA-Norwich/Practices">Practices</a></li>
                                     <li  ><a href="/Team:NRP-UEA-Norwich/Collaborations">Collaborations</a></li>                                     
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                                     <li  ><a href="/Team:NRP-UEA-Norwich/Collaborations">Collaborations</a></li>
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                                    <li  ><a href="/Team:NRP-UEA-Norwich/Achievements">Achievements</a></li>                                     
 
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    <h1 class="title1">Practices Overview</h2>
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<h1 class="title1">PRACTICES</h2>
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    <h3 class="title">“What does the Cancer Community think of our Project?”</h3>
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<h4 class="title">Integrated Policy and Practices </h4>
 
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     <p class="space20">We built these models to see how changing the parameters such as branching degree and the number of tiers affect the overall structure of the molecule in a more chemically accurate way.</p>
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     <p class="space20">Our team consulted with Chris Bushby and Nikki Morris, the CEO and Deputy CEO of <a href="http://www.big-c.co.uk/" style = "color: #002bb8;">Big C</a>, a prominent UK-based cancer charity to gain some perspective on the ethics of cancer treatment/prevention. We discussed the ethics of preventative diets, how our product could be made available and promoted as a cancer-preventative measure. A key learning point was that while the genetic engineering of food is still controversial in Europe, opinions may differ when the reasons for engineering are for the prevention of cancer. </p>
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<p class="space20">In short, we learned that society’s collective moral hierarchy may place preventing cancer above objecting to the genetic engineering of food plants.</p>
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<p class="space20">You can learn more by clicking on the image on the right.</p>
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                        <img src="https://static.igem.org/mediawiki/2015/8/8a/NRP-UEA-Norwich-bigcbigger.png" class="img-responsive ">
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                          <a title="BigC"  href="https://2015.igem.org/Team:NRP-UEA-Norwich/Practices/BigC" class="btn outlinebtn  space50">
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     <h3 class="title">Glycogen</h2>
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     <h3 class="title">"How could we test the efficacy of our products?" </h3>
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<h4 class="title">Integrated Policy and Practices </h4>
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     <p class="space20"> Glycogen is a polysaccharide composed of glucose units linked by alpha 1-4 glycosidic bonds. Each linear chain contains approximately 13 glucose residues and, except of course for the outermost tier of the molecule, a number of alpha 1-6 glycosidic bonds, which allow branching, that are 3–4 residues apart.</p>
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     <p class="space20">There are significant ethical considerations with the production of genetically engineered food supplements. We were particularly interested in investigating which of our two possible approaches for increasing butyrate  would make a more ethical product and also how we would be able to show efficacy of either in humans.  
  
        <p class="space20">This simple model - created for our wiki by the SWEET software - shows a small section of a glycogen molecule consisting of 91 glucose units which are contained within 7 branches and 3 tiers. The 1-4 linked sections can be seen to coil into a helical shape, and the 1-6 linkages form helical branches away from the centre of the molecule.</p>
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        <p class="space20">To find out about how health benefits are usually tested, we consulted experts in the Department of Nutrition at the Norwich Medical School at the University of East Anglia who have expertise in designing human intervention studies to determine the health benefits of foods and dietary supplements. We then designed a theoretical feeding trial that would test the efficacy of our products. </p>
  
<p class="space20">You can interact with the model using your mouse.</p>
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<p class="space20">You can learn more by clicking on the image on the right.</p>
  
  
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                           <a title="Integrated human practices"  href="https://2015.igem.org/Team:NRP-UEA-Norwich/Practices/ClinicalTrial" class="btn outlinebtn  space50">
 
                             Read More
 
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     <h3 class="title">Amylose</h2>
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     <h3 class="title">"What do people know about modified starches? "</h3>
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<h4 class="title">Education and Public Outreach</h4>
 
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     <p class="space20"> <b>Colon cancer is the second most common cause of cancer death </b> with 30,000 new cases diagnosed every year in England and Wales and a registered cause of death in half that number. </p>
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     <p class="space20">We are interested in whether people were aware of the wide use of modified starches so we took a display of starches to our city’s landmark Science Communication Day, “Science in Norwich”. </p>
  
        <p class="space20">Recent studies have suggested that <b>high dietary intake of resistant starch</b> may reduce colon cancer and inflammatory bowel disease. Resistant starches escape digestion in the small intestine and are fermented by microbiota in the colon. A small proportion of these colonic bacteria produce <b>short chain fatty acids including butyrate</b>, which can activate apoptosis in colon cancer cells.</p>
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        <p class="space20">To demonstrate some of the properties and uses of starch such as caking agent, binding agent and crosslinker we make some fun products from starches. We made these from gluten free starches and ingredients from our kitchen cupboard so that they were safe and available to everyone.</p>
  
<p class="space20">Our project is focused on increasing the amount of butyrate in the colon.</p>
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<p class="space20">You can learn more by clicking on the image on the right.</p>
  
  
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                         <img src="https://static.igem.org/mediawiki/2015/thumb/d/d7/NRP-UEA-Norwich-scienceinnorwich.jpg/800px-NRP-UEA-Norwich-scienceinnorwich.jpg" class="img-responsive"style ="width:487px; height:390px;">
 
                            
 
                            
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                           <a title="Science In Norwich"  href="https://2015.igem.org/Team:NRP-UEA-Norwich/Practices/ScienceInNorwich" class="btn outlinebtn  space50">
 
                             Read More
 
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     <h3 class="title">Amylopectin</h2>
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     <h3 class="title">"Communicating the Anxieties and Awesomeness of Bioengineering - A Workshop for Scientists and Poets”</h2>
 
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     <p class="space20"> <b>Colon cancer is the second most common cause of cancer death </b> with 30,000 new cases diagnosed every year in England and Wales and a registered cause of death in half that number. </p>
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     <p class="space20">Being in Norwich, we are lucky enough to live in a city which does not just host a <a href="http://www.norwichresearchpark.com/home.aspx" style = "color: #002bb8;"> world-leading scientific research park</a>, but is also a <a
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href="http://www.writerscentrenorwich.org.uk/unescocityofliterature.aspx"> UNESCO City of Literature</a>. We worked with the <a href="http://www.sawtrust.org"  style = "color: #002bb8;"> Science and Writing Trust (SAW)</a>, to hold a workshop for established poets at the amazing Dragon Hall, a beautiful medieval building and home to the Norwich Writers Centre. </p>
  
        <p class="space20">Recent studies have suggested that <b>high dietary intake of resistant starch</b> may reduce colon cancer and inflammatory bowel disease. Resistant starches escape digestion in the small intestine and are fermented by microbiota in the colon. A small proportion of these colonic bacteria produce <b>short chain fatty acids including butyrate</b>, which can activate apoptosis in colon cancer cells.</p>
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        <p class="space20">At the workshop we talked about our project, iGEM and bioengineering with established and published poets. They (and us!) conducted writing exercises guided by the published poet, Esther Morgan in which we expressed our emotions, concerns and awe of science.  This workshop resulted in a collaborative collection of poems by writers and scientists. </p>
  
<p class="space20">Our project is focused on increasing the amount of butyrate in the colon.</p>
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<p class="space20">You can learn more by clicking on the image on the right.</p>
  
  
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                             Read More
 
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    <h2 class="title1">References</h2>
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    <p class="space20">http://www.biotopics.co.uk/jsmol/glycogen.html</p>
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<p class="space20">http://watcut.uwaterloo.ca/webnotes/Metabolism/glycogenStructure.html. </p>
 
  
<p class="space20">"Photonic" and "spintronic" computing is the principle of transferring information by light or electron spin.</p>
 
 
            <p class="space20">Currently, copper wires transfer information in a computer; the process is slowed down as the wires heat up. "Photonic" and "spintronic" computing is the principle of transferring information by light or electron spin.</p>
 
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                     <h2 class="gray">MANY THANKS TO OUR SPONSORS</h2>
 
                     <h2 class="gray">MANY THANKS TO OUR SPONSORS</h2>
 
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Latest revision as of 10:37, 21 October 2015

House of Carbs

PRACTICES

“What does the Cancer Community think of our Project?”

Integrated Policy and Practices

Our team consulted with Chris Bushby and Nikki Morris, the CEO and Deputy CEO of Big C, a prominent UK-based cancer charity to gain some perspective on the ethics of cancer treatment/prevention. We discussed the ethics of preventative diets, how our product could be made available and promoted as a cancer-preventative measure. A key learning point was that while the genetic engineering of food is still controversial in Europe, opinions may differ when the reasons for engineering are for the prevention of cancer.

In short, we learned that society’s collective moral hierarchy may place preventing cancer above objecting to the genetic engineering of food plants.

You can learn more by clicking on the image on the right.

"How could we test the efficacy of our products?"

Integrated Policy and Practices

There are significant ethical considerations with the production of genetically engineered food supplements. We were particularly interested in investigating which of our two possible approaches for increasing butyrate would make a more ethical product and also how we would be able to show efficacy of either in humans.

To find out about how health benefits are usually tested, we consulted experts in the Department of Nutrition at the Norwich Medical School at the University of East Anglia who have expertise in designing human intervention studies to determine the health benefits of foods and dietary supplements. We then designed a theoretical feeding trial that would test the efficacy of our products.

You can learn more by clicking on the image on the right.

"What do people know about modified starches? "

Education and Public Outreach

We are interested in whether people were aware of the wide use of modified starches so we took a display of starches to our city’s landmark Science Communication Day, “Science in Norwich”.

To demonstrate some of the properties and uses of starch such as caking agent, binding agent and crosslinker we make some fun products from starches. We made these from gluten free starches and ingredients from our kitchen cupboard so that they were safe and available to everyone.

You can learn more by clicking on the image on the right.

"Communicating the Anxieties and Awesomeness of Bioengineering - A Workshop for Scientists and Poets”

Being in Norwich, we are lucky enough to live in a city which does not just host a world-leading scientific research park, but is also a UNESCO City of Literature. We worked with the Science and Writing Trust (SAW), to hold a workshop for established poets at the amazing Dragon Hall, a beautiful medieval building and home to the Norwich Writers Centre.

At the workshop we talked about our project, iGEM and bioengineering with established and published poets. They (and us!) conducted writing exercises guided by the published poet, Esther Morgan in which we expressed our emotions, concerns and awe of science. This workshop resulted in a collaborative collection of poems by writers and scientists.

You can learn more by clicking on the image on the right.

MANY THANKS TO OUR SPONSORS

Useful Links

Contact Us

  • nrpuea.igem2015@gmail.com

  • Norwich Research Park,
  • Colney,
  • Norwich, NR4 7UH, UK.

We are the NRP-UEA-Norwich 2015 iGEM Team.

Designed and developed by the NRP-UEA-Norwich iGEM Team