Difference between revisions of "Team:TrinityCollegeDublin"

 
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<h3> Project Description </h3>
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<p>In our project, we will re-engineer the production of artemisinin in E-coli to hopefully provide a cheaper option with which to fight malaria. The disease is caused by the parasite, Plasmodium, and is transmitted in the bites of Anopheles mosquitoes that have picked up the parasite from other recently infected animals they have fed on. When left untreated, malaria can be fatal, disrupting proper blood flow and impeding the functions of vital organs in the body. The disease claims over 600,000 lives a year. Most of these lives are in poor underdeveloped regions, where people are unable to afford the drug.</p>
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<p>Synthetic artemisinin is perhaps the poster-child achievement of synthetic biology. Our team will work with artemisinic acid producing e-coli cells, obtained from Amyris, with the support of Zagaya. By expressing Dbr2, and other dehydrogenases in the artemisinin metabolic pathway we hope to improve the efficiency of artemisinin production. We have synthesized the bio-bricked components of the system, which should allow for an easier engagement with research on the topic in the future.</p>
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    <div class="logo logoAnimation"><a href="https://2015.igem.org/Team:TrinityCollegeDublin"><img src=
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<h2> Welcome to iGEM 2015! </h2>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<h4>Before you start: </h4>
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<p> Please read the following pages:</p>
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                        <a href=
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<li> <a href="https://2015.igem.org/Requirements">Requirements page </a> </li>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Background">
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<li> <a href="https://2015.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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                        Background</a>
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<h4> Styling your wiki </h4>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Design">
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
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                        E.artemisia Design</a>
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<h4> Editing your wiki </h4>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p> <a href="https://2015.igem.org/wiki/index.php?title=Team:TrinityCollegeDublin&action=edit"> Click here to edit this page! </a></p>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Results">
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<p>See tips on how to edit your wiki on the <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation</a> page.</p>  
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                        Results</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Conclusions">
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                        Conclusions</a>
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<h4>Templates </h4>
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<p> This year we have created templates for teams to use freely. More information on how to use and edit the templates can be found on the
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<a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation </a> page.</p>  
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Measurement">
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                        Interlab</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Part_Collection">
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                        Parts</a>
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<h4>Tips</h4>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2015.igem.org/Calendar_of_Events">iGEM 2015 calendar</a> </li>
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<li>Have lots of fun! </li>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Timeline">
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                        Timeline</a>
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<h4>Inspiration</h4>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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                        <a href=
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Protocols">
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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                        Protocols</a>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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</ul>
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<h4> Uploading pictures and files </h4>
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<p> You can upload your pictures and files to the iGEM 2015 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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<a href="https://2015.igem.org/Special:Upload">CLICK HERE TO UPLOAD FILES</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Practices">
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                        Global Health</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Malaria">
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                        Malaria</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/GenderInequality">
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                        Gender Inequality</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Children">
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                        Children</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Logistics">
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                        Logistics</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Future">
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                        Future</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Interviews">
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                        Interviews</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Team">Team</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Attributions">
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                        Attributions</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Outreach">
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                        Outreach</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Sponsors">
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                        Sponsors</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Gallery">
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                        Gallery</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Safety">
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                        Safety</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Achievements">
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                        Achievements</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/Collaborations">
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                        iGEM Academy</a>
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                        "https://2015.igem.org/Team:TrinityCollegeDublin/CorkiGEM">
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                        Cork iGEM</a>
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        <h1 class="headingOne">E.artemisia</h1>
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        <h2>Combating Malaria with Synthetic Biology</h2>
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        One of the deadliest diseases in human history, <b>malaria now claims over 600,000 lives a year</b>.
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<br><br>
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Our mission is to investigate the <b>production of affordable antimalarial drugs</b> by the means of synthetic biology. We are working with <b>artemisinic acid producing E.coli cells</b> obtained from Amyris, with the support of Zagaya.
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<br><br><br>
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We have constructed biobricks to take advantage of an <b>alternative pathway in artemesinin synthesis</b>. This pathway allows for the production of <b>dihydroartemisinic acid</b>, a direct precursor to artemisinin.
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<br><br>
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This method has the potential for larger and cheaper artemisinin production in the future.
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Latest revision as of 15:11, 26 October 2015

E.artemisia

Combating Malaria with Synthetic Biology




One of the deadliest diseases in human history, malaria now claims over 600,000 lives a year.

Our mission is to investigate the production of affordable antimalarial drugs by the means of synthetic biology. We are working with artemisinic acid producing E.coli cells obtained from Amyris, with the support of Zagaya.


We have constructed biobricks to take advantage of an alternative pathway in artemesinin synthesis. This pathway allows for the production of dihydroartemisinic acid, a direct precursor to artemisinin.

This method has the potential for larger and cheaper artemisinin production in the future.