Difference between revisions of "Team:Pasteur Paris/Modeling"

 
(29 intermediate revisions by 6 users not shown)
Line 2: Line 2:
 
<html>
 
<html>
  
−
<h2> Modeling</h2>
+
<img src="https://static.igem.org/mediawiki/2015/c/cf/Modeling_pasteur2015.jpg" style="width: 100%;"/>
  
 +
<br><br><br>
 +
<div class="carregris">
 +
<p>Our Project takes advantage of a multi enzyme metabolic pathway. We have decided to generate a model of enzyme kinetics for one to many successive steps in catalysis. We thought that it would be interresting to study the successive evolution of differents substrates in the cell. We used the <b>model of Michaelis-Menten</b> as the basis of our model. We have solved this equation with the <b>Euler-Cauchy method</b>.</p>
 +
<p>The first goal of this part in our project was to generate a fitting curve fonction, but we have finally developped a tool that can generate solutions for many enzymatic systems respecting the Michaelis-Menten enzyme model. This tool can be used as a basis for creating a fitting <b>curve function</b>. But it can also be used as an <b>education tool</b> to provide another approach to the enzyme kinetic modeling. </p>
  
−
<div class="highlightBox">
+
<p>To build this tool, we rely on a spreadsheet : <a href="https://static.igem.org/mediawiki/2015/4/45/MMtab3.xls">Modeling tool for enzymatic reaction</a>  
−
<h4>Note</h4>
+
<p>For the description of an equation used in the spreadsheet : <a href="https://static.igem.org/mediawiki/2015/d/d4/MM5-_Copie.pdf">Model to describe enzymatic reaction </a>
−
<p>In order to be considered for the <a href="https://2015.igem.org/Judging/Awards#SpecialPrizes">Best Model award</a>, you must fill out this page.</p>
+
</p>
 
</div>
 
</div>
 +
<br>
  
 +
<!-- Renvoie haut de page -->
 +
<center>
 +
<a class="hautdepage" href="#"><p><span style="font-size: 60px; font-family: Courier;">^</span><br/><span style="font-size: 20px;">Page up</span></p></a>
 +
</center>
 +
<style type="text/css">
 +
.hautdepage {
 +
    color: #1F89DA;
 +
}
  
−
<p>Mathematical models and computer simulations provide a great way to describe the function and operation of BioBrick Parts and Devices. Synthetic Biology is an engineering discipline, and part of engineering is simulation and modeling to determine the behavior of your design before you build it. Designing and simulating can be iterated many times in a computer before moving to the lab. This award is for teams who build a model of their system and use it to inform system design or simulate expected behavior in conjunction with experiments in the wetlab.</p>
+
.hautdepage:hover {
−
 
+
    color: #0067B6;
−
<p>
+
}
−
Here are a few examples from previous teams:
+
</style>
−
</p>
+
−
<ul>
+
−
<li><a href="https://2014.igem.org/Team:ETH_Zurich/modeling/overview">ETH Zurich 2014</a></li>
+
−
<li><a href="https://2014.igem.org/Team:Waterloo/Math_Book">Waterloo 2014</a></li>
+
−
</ul>
+
−
 
+
−
 
+
−
</div>
+
  
 
</html>
 
</html>

Latest revision as of 17:59, 11 November 2015




Our Project takes advantage of a multi enzyme metabolic pathway. We have decided to generate a model of enzyme kinetics for one to many successive steps in catalysis. We thought that it would be interresting to study the successive evolution of differents substrates in the cell. We used the model of Michaelis-Menten as the basis of our model. We have solved this equation with the Euler-Cauchy method.

The first goal of this part in our project was to generate a fitting curve fonction, but we have finally developped a tool that can generate solutions for many enzymatic systems respecting the Michaelis-Menten enzyme model. This tool can be used as a basis for creating a fitting curve function. But it can also be used as an education tool to provide another approach to the enzyme kinetic modeling.

To build this tool, we rely on a spreadsheet : Modeling tool for enzymatic reaction

For the description of an equation used in the spreadsheet : Model to describe enzymatic reaction


^
Page up