Difference between revisions of "Team:Evry"

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{{Evry}}
 
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<html>
 
<html>
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<h2> Welcome to iGEM 2015! </h2>
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    <!-- Main Content -->
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<div class='side-body hidden-xs parallax' style="width: calc(100%-250px); height: 550px; background: linear-gradient(rgba(0, 0, 0, 0.3), rgba(0, 0, 0, 0.3)), url('https://static.igem.org/mediawiki/2015/5/5d/Homepage_header_background_optimized.jpg'); background-size: cover;">
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      <div style="position: relative; top: 50%; transform: translateY(-50%);  -webkit-transform: translateY(-50%);">
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<h4>Before you start: </h4>
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        <p class="text-center" style="font-weight: 400; font-size:4em; color: #ffffff; text-shadow: 0px 0px 8px #222222;">Welcome on board!</p>
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<p> Please read the following pages:</p>
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        <p class="text-center" style="font-weight: 300; font-size:3em; color: #ffffff; text-shadow: 0px 0px 8px #222222;">iGEM Evry 2015</p>
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<ul>
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        <p class="text-center" style="font-weight: 200; font-size:2em; color: #ffffff; text-shadow: 0px 0px 8px #222222;">The YETI project to reshape the immune landscape</p>
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<li>  <a href="https://2015.igem.org/Requirements">Requirements page </a> </li>
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      </div>
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<li> <a href="https://2015.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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</ul>
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<div class="highlightBox">
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<h4> Styling your wiki </h4>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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</div>
 
</div>
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        <div class="container">
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        <div class="side-body" id="content-body">
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<div id='top-menu-anchor'></div>
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<div id="top-menu"></div>
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    <div class="page-header">
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    <h1>Let's begin with a small abstract</h1>
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    </div>
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<section class="page-section">
  
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<h4> Editing your wiki </h4>
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<p class="text-justify">
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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Cancer thrives by preventing the <strong>immune system</strong> from targeting tumor cells. While current immunotherapies use dendritic cells to activate T-cells towards specific tumor antigens, they remain expensive and of variable efficiency against tumor immunosuppressive environment. To develop <strong>personalized therapies</strong>, our team focused on engineering yeast <em>Saccharomyces cerevisiae</em> for targeted immunotherapy. First, we developed a <strong>software to select the best tumor antigen</strong> from patient sequencing data. Second, we created a <strong>yeast chassis</strong> to prime the immune system with the targeted antigen. This chassis was tested <em>in vitro</em> on mouse splenocytes and <em>in vivo</em> on mice presenting melanoma with significant results. Three complementary strategies were combined to induce the immune system. First, in order to modulate the <strong>tumor environment</strong>, yeast secreting the specific immune modulator IFNgamma was encapsulated into alginate beads to be injected in tumors. Secondly, to <strong>break the immune tolerance</strong> against cancer cells, T4 and T8 lymphocytes were elicited by a yeast antigen display system that can be adapted to any tumor antigen for personalized therapy. Last, to <strong>deliver cytotoxic compounds</strong> solely in the tumor environment, a yeast hypoxia bio-sensor was designed. Our <strong>standardized</strong> and <strong>customizable</strong> chassis takes advantage of these approaches to make personalized medicine a reality, with a scalable cancer therapy.</p>
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<p> <a href="https://2015.igem.org/wiki/index.php?title=Team:Evry&action=edit"> Click here to edit this page! </a></p>
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</section>
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<p>See tips on how to edit your wiki on the <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation</a> page.</p>
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<h4>Templates </h4>
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<p> This year we have created templates for teams to use freely. More information on how to use and edit the templates can be found on the
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<a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation </a> page.</p>
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<h4>Tips</h4>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2015.igem.org/Calendar_of_Events">iGEM 2015 calendar</a> </li>
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<li>Have lots of fun! </li>
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</ul>
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<h4>Inspiration</h4>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<ul>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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</ul>
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<h4> Uploading pictures and files </h4>
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<p> You can upload your pictures and files to the iGEM 2015 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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<p>First edit.</p>
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<a href="https://2015.igem.org/Special:Upload">CLICK HERE TO UPLOAD FILES</a>
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<section class="page-section">
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<p class="text-justify lead">Read our <a href="https://2015.igem.org/Team:Evry/Description">project description</a> to learn more!</p>
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</section>
  
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<!--div id="img-div"><img src="https://static.igem.org/mediawiki/2015/8/8a/Shcema_immune_syst.jpg" class="img-rounded img-responsive"></img></div-->
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<!--p class="lead">Dendritic cells can orchestrate the immune response. By acting on them using engineered micro-organisms,
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we want to <a href="https://2015.igem.org/Team:Evry/Project/Induction">induce</a> or <a href="https://2015.igem.org/Team:Evry/Project/Repression">repress</a> the immune response when the immune system fails.</p-->
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{{:Team:Evry/Template:Footer}}
 
{{:Team:Evry/Template:Footer}}

Latest revision as of 20:09, 20 November 2015

   

Let's begin with a small abstract

Cancer thrives by preventing the immune system from targeting tumor cells. While current immunotherapies use dendritic cells to activate T-cells towards specific tumor antigens, they remain expensive and of variable efficiency against tumor immunosuppressive environment. To develop personalized therapies, our team focused on engineering yeast Saccharomyces cerevisiae for targeted immunotherapy. First, we developed a software to select the best tumor antigen from patient sequencing data. Second, we created a yeast chassis to prime the immune system with the targeted antigen. This chassis was tested in vitro on mouse splenocytes and in vivo on mice presenting melanoma with significant results. Three complementary strategies were combined to induce the immune system. First, in order to modulate the tumor environment, yeast secreting the specific immune modulator IFNgamma was encapsulated into alginate beads to be injected in tumors. Secondly, to break the immune tolerance against cancer cells, T4 and T8 lymphocytes were elicited by a yeast antigen display system that can be adapted to any tumor antigen for personalized therapy. Last, to deliver cytotoxic compounds solely in the tumor environment, a yeast hypoxia bio-sensor was designed. Our standardized and customizable chassis takes advantage of these approaches to make personalized medicine a reality, with a scalable cancer therapy.

Read our project description to learn more!

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